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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 47

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Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3.
Archibald A, Mihai C, Macara IG, McCaffrey L
(2015) Oncogene 34: 3199-206
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Apoptosis, Breast Neoplasms, Cell Adhesion Molecules, Cell Cycle Proteins, Cell Polarity, Cell Transformation, Neoplastic, Cells, Cultured, Down-Regulation, Female, MAP Kinase Signaling System, Mammary Glands, Animal, Mice, Neuropeptides, RNA Interference, RNA, Small Interfering, Spheroids, Cellular, rac1 GTP-Binding Protein
Added April 10, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.
Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE
(2014) J Biol Chem 289: 4219-32
MeSH Terms: Amino Acid Substitution, Animals, Cattle, Cell Line, Extracellular Signal-Regulated MAP Kinases, Glycoproteins, Humans, Multienzyme Complexes, Mutation, Missense, Phosphorylation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-raf, Proto-Oncogene Proteins p21(ras), Rats, rac1 GTP-Binding Protein, ras Proteins
Added March 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
EphA2 signaling following endocytosis: role of Tiam1.
Boissier P, Chen J, Huynh-Do U
(2013) Traffic 14: 1255-71
MeSH Terms: Animals, Cell Line, Tumor, Cell Membrane, Endocytosis, Guanine Nucleotide Exchange Factors, Humans, Lysosomes, Mice, Receptor, EphA2, Signal Transduction, T-Lymphoma Invasion and Metastasis-inducing Protein 1, rac1 GTP-Binding Protein
Added March 5, 2014
1 Communities
1 Members
0 Resources
12 MeSH Terms
Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability.
Zebda N, Tian Y, Tian X, Gawlak G, Higginbotham K, Reynolds AB, Birukova AA, Birukov KG
(2013) J Biol Chem 288: 18290-9
MeSH Terms: Adherens Junctions, Antigens, CD, Binding Sites, Blotting, Western, Cadherins, Catenins, Cell Membrane, Cell Membrane Permeability, Cells, Cultured, Cytoskeleton, Endothelial Cells, Fluorescent Antibody Technique, GTPase-Activating Proteins, Guanine Nucleotide Exchange Factors, HEK293 Cells, Humans, Mutation, Phosphatidylcholines, Protein Binding, Protein Interaction Mapping, Repressor Proteins, Thrombin, p21-Activated Kinases, rac1 GTP-Binding Protein
Added March 7, 2014
1 Communities
1 Members
0 Resources
24 MeSH Terms
Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.
Ali WH, Chen Q, Delgiorno KE, Su W, Hall JC, Hongu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, Frohman MA
(2013) PLoS One 8: e55325
MeSH Terms: Animals, Blotting, Western, Cytoskeleton, Macrophages, Mice, Neuropeptides, Neutrophil Infiltration, Pancreatitis, Phagocytosis, Phosphatidic Acids, Phospholipase D, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added March 13, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension.
Johnson JA, Hemnes AR, Perrien DS, Schuster M, Robinson LJ, Gladson S, Loibner H, Bai S, Blackwell TR, Tada Y, Harral JW, Talati M, Lane KB, Fagan KA, West J
(2012) Am J Physiol Lung Cell Mol Physiol 302: L474-84
MeSH Terms: Amino Acid Substitution, Angiotensin-Converting Enzyme 2, Animals, Blood Pressure, Bone Morphogenetic Protein Receptors, Type II, Cells, Cultured, Cytoskeleton, Endothelial Cells, Enzyme Activation, Familial Primary Pulmonary Hypertension, Female, Gene Expression Profiling, Heart Ventricles, Humans, Hypertension, Pulmonary, Lung, Male, Mice, Mice, Transgenic, Microvessels, Neuropeptides, Oligonucleotide Array Sequence Analysis, Peptidyl-Dipeptidase A, Phosphorylation, Recombinant Proteins, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added April 25, 2013
0 Communities
3 Members
0 Resources
27 MeSH Terms
Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO
(2012) J Biol Chem 287: 1600-8
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Axons, Brain-Derived Neurotrophic Factor, Carrier Proteins, Cell Adhesion Molecules, Cell Cycle Proteins, Cell Movement, Cells, Cultured, Mice, Myelin Sheath, Nerve Tissue Proteins, Neuroglia, Neuropeptides, Rats, Schwann Cells, Signal Transduction, Zebrafish, Zebrafish Proteins, rac GTP-Binding Proteins, rac1 GTP-Binding Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Effective treatments for PAH will require detailed knowledge of molecular aetiology.
Johnson J, Loyd J, West J
(2010) Int J Clin Pract Suppl : 3-4
MeSH Terms: Bone Morphogenetic Protein Receptors, Type II, Drug Design, Estrogens, Heterozygote, Humans, Hypertension, Pulmonary, Mutation, rac1 GTP-Binding Protein
Added March 7, 2014
0 Communities
2 Members
0 Resources
8 MeSH Terms
Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation.
Elias BC, Bhattacharya S, Ray RM, Johnson LR
(2010) Cell Adh Migr 4: 419-30
MeSH Terms: Cell Adhesion, Cell Line, Cell Movement, Enzyme Activation, Extracellular Matrix, Fibronectins, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, Guanine Nucleotide Exchange Factors, Models, Biological, Oligopeptides, Polyamines, Protein Binding, Signal Transduction, rac1 GTP-Binding Protein, src-Family Kinases
Added February 25, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators.
Wang SE, Yu Y, Criswell TL, Debusk LM, Lin PC, Zent R, Johnson DH, Ren X, Arteaga CL
(2010) Oncogene 29: 3335-48
MeSH Terms: Cell Line, ErbB Receptors, Humans, JNK Mitogen-Activated Protein Kinases, Mutation, Neoplasms, Proto-Oncogene Proteins p21(ras), Receptor, ErbB-2, Signal Transduction, Transcription Factor AP-1, Transforming Growth Factor beta1, Vascular Endothelial Growth Factor A, rac1 GTP-Binding Protein
Added December 10, 2013
1 Communities
1 Members
0 Resources
13 MeSH Terms