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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 28

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The poisons within: application of toxicity mechanisms to fundamental disease processes.
Liebler DC
(2006) Chem Res Toxicol 19: 610-3
MeSH Terms: Atherosclerosis, Drug-Related Side Effects and Adverse Reactions, Humans, Metabolic Syndrome, Neurodegenerative Diseases, Oxidants, Oxidative Stress, Toxicology, Xenobiotics
Added March 20, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Life and times in biochemical toxicology.
Guengerich FP
(2005) Int J Toxicol 24: 5-21
MeSH Terms: Animals, Biochemistry, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Toxicology, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Elucidating mechanisms of drug-induced toxicity.
Liebler DC, Guengerich FP
(2005) Nat Rev Drug Discov 4: 410-20
MeSH Terms: Animals, Drug-Related Side Effects and Adverse Reactions, Humans, Xenobiotics
Added March 5, 2014
0 Communities
2 Members
0 Resources
4 MeSH Terms
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor.
Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD
(2005) Mol Endocrinol 19: 1646-53
MeSH Terms: Animals, Apoptosis, Cell Proliferation, Chromatin Immunoprecipitation, Constitutive Androstane Receptor, DNA, DNA Fragmentation, Flow Cytometry, HeLa Cells, Hepatocytes, Hepatomegaly, Humans, Liver, Liver Neoplasms, Mice, Mice, Transgenic, Nuclear Proteins, Protein Binding, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-mdm2, RNA, Receptors, Cytoplasmic and Nuclear, Time Factors, Transcription Factors, Transfection, Tumor Suppressor Protein p53, Up-Regulation, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
28 MeSH Terms
Cytochrome P450: what have we learned and what are the future issues?
Guengerich FP
(2004) Drug Metab Rev 36: 159-97
MeSH Terms: Animals, Catalysis, Cytochrome P-450 Enzyme System, DNA Shuffling, Ferric Compounds, Gene Expression Regulation, Enzymologic, Humans, Ligands, Neoplasms, Polymorphism, Genetic, Protein Conformation, Protein Processing, Post-Translational, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Cytochromes P450, drugs, and diseases.
Guengerich FP
(2003) Mol Interv 3: 194-204
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Disease, Humans, Neoplasms, Pharmaceutical Preparations, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB
(2003) Nat Med 9: 220-4
MeSH Terms: Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Constitutive Androstane Receptor, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, DNA Primers, DNA-Binding Proteins, Electrophoretic Mobility Shift Assay, Enhancer Elements, Genetic, Enzyme Induction, Hepatocyte Nuclear Factor 4, Humans, Male, Mice, Mice, Inbred C57BL, Phosphoproteins, Pregnane X Receptor, Receptors, Cytoplasmic and Nuclear, Receptors, Steroid, Transcription Factors, Tumor Cells, Cultured, Xenobiotics
Added March 27, 2014
1 Communities
1 Members
1 Resources
23 MeSH Terms
Effects of nonylphenol, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), and pentachlorophenol on the adult female guinea pig reproductive tract.
Danzo BJ, Shappell HW, Banerjee A, Hachey DL
(2002) Reprod Toxicol 16: 29-43
MeSH Terms: Animals, Castration, Cervix Uteri, Dichlorodiphenyl Dichloroethylene, Diethylstilbestrol, Endometrium, Epithelium, Estradiol, Estrogen Receptor Modulators, Female, Genital Diseases, Female, Genitalia, Female, Guinea Pigs, Hyperplasia, Metaplasia, Organ Size, Pentachlorophenol, Phenols, Receptors, Estrogen, Vagina, Xenobiotics
Added March 20, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T
(2002) Protein Expr Purif 24: 329-37
MeSH Terms: Cell Membrane, Cytochrome P-450 Enzyme System, Cytochromes b5, Escherichia coli, Humans, Microsomes, Liver, NADPH-Ferrihemoprotein Reductase, Oxidation-Reduction, Recombinant Proteins, Xenobiotics
Added May 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity.
Guengerich FP
(2001) Chem Res Toxicol 14: 611-50
MeSH Terms: Aldehydes, Animals, Biotransformation, Catalysis, Cytochrome P-450 Enzyme System, Electrons, Esters, Fatty Acids, Humans, Kinetics, Oxidation-Reduction, Peroxidases, Phospholipase D, Xenobiotics
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms