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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 20

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Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.
Gong IY, Schwarz UI, Crown N, Dresser GK, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Wells PS, Kim RB, Tirona RG
(2011) PLoS One 6: e27808
MeSH Terms: Adult, Aged, Aged, 80 and over, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Blood Coagulation, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Female, Gene Frequency, Genotype, Humans, Kidney Function Tests, Male, Middle Aged, Mixed Function Oxygenases, Prospective Studies, Tissue Distribution, Vitamin K, Vitamin K Epoxide Reductases, Warfarin, Young Adult
Added June 26, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy.
Gong IY, Tirona RG, Schwarz UI, Crown N, Dresser GK, Larue S, Langlois N, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Carrier M, Forgie M, Wells PS, Kim RB
(2011) Blood 118: 3163-71
MeSH Terms: Adult, Aged, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cohort Studies, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Drug Resistance, Female, Humans, Male, Middle Aged, Mixed Function Oxygenases, Pharmacogenetics, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin, Whole Blood Coagulation Time
Added June 26, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin.
Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC
(2011) J Am Med Inform Assoc 18: 387-91
MeSH Terms: Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Data Mining, Databases, Nucleic Acid, Drug Dosage Calculations, Electronic Health Records, Genome-Wide Association Study, Humans, Linear Models, Mixed Function Oxygenases, Natural Language Processing, Pharmacogenetics, Precision Medicine, United States, Vitamin K Epoxide Reductases, Warfarin
Added December 10, 2013
0 Communities
3 Members
0 Resources
18 MeSH Terms
The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.
Perera MA, Gamazon E, Cavallari LH, Patel SR, Poindexter S, Kittles RA, Nicolae D, Cox NJ
(2011) Clin Pharmacol Ther 89: 408-15
MeSH Terms: African Americans, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Base Sequence, Cohort Studies, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Female, Genetic Variation, Humans, Male, Middle Aged, Mixed Function Oxygenases, Polymorphism, Single Nucleotide, Regression Analysis, Vitamin K Epoxide Reductases, Warfarin
Added February 22, 2016
0 Communities
2 Members
0 Resources
18 MeSH Terms
VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.
Crawford DC, Brown-Gentry K, Rieder MJ
(2010) PLoS One 5: e15088
MeSH Terms: Adult, African Americans, Bone Density, Female, Genetic Variation, Genotype, Health Surveys, Hispanic Americans, Humans, Linkage Disequilibrium, Male, Mixed Function Oxygenases, Nutrition Surveys, Polymorphism, Single Nucleotide, Vitamin K 2, Vitamin K Epoxide Reductases
Added December 10, 2013
0 Communities
1 Members
0 Resources
16 MeSH Terms
Estimation of the warfarin dose with clinical and pharmacogenetic data.
International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA
(2009) N Engl J Med 360: 753-64
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Child, Cohort Studies, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Female, Genotype, Humans, International Normalized Ratio, Least-Squares Analysis, Male, Middle Aged, Mixed Function Oxygenases, Pharmacogenetics, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin, Young Adult
Added June 26, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.
Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D
(2009) Blood 113: 3925-30
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Female, Genotype, Humans, International Normalized Ratio, Male, Middle Aged, Mixed Function Oxygenases, Substrate Specificity, Treatment Outcome, Vitamin K Epoxide Reductases, Warfarin
Added December 10, 2013
0 Communities
2 Members
0 Resources
14 MeSH Terms
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.
Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwarz UI, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ
(2008) Blood 112: 1022-7
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Genomics, Genotype, Humans, Mixed Function Oxygenases, Pharmacogenetics, Polymorphism, Single Nucleotide, Randomized Controlled Trials as Topic, Retrospective Studies, Vitamin K Epoxide Reductases, Warfarin
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Genetic determinants of response to warfarin during initial anticoagulation.
Schwarz UI, Ritchie MD, Bradford Y, Li C, Dudek SM, Frye-Anderson A, Kim RB, Roden DM, Stein CM
(2008) N Engl J Med 358: 999-1008
MeSH Terms: Adult, Aged, Anticoagulants, Cohort Studies, Cytochrome P-450 Enzyme System, Female, Genotype, Haplotypes, Humans, International Normalized Ratio, Linkage Disequilibrium, Male, Middle Aged, Mixed Function Oxygenases, Polymorphism, Genetic, Vitamin K Epoxide Reductases, Warfarin
Added December 10, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
Genetic determinants of dose and clinical outcomes in patients receiving oral anticoagulants.
Schwarz UI, Stein CM
(2006) Clin Pharmacol Ther 80: 7-12
MeSH Terms: Acenocoumarol, Administration, Oral, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Genotype, Humans, Mixed Function Oxygenases, Vitamin K Epoxide Reductases, Warfarin
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms