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Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses.
Singh K, Coburn LA, Asim M, Barry DP, Allaman MM, Shi C, Washington MK, Luis PB, Schneider C, Delgado AG, Piazuelo MB, Cleveland JL, Gobert AP, Wilson KT
(2018) Cancer Res 78: 4303-4315
MeSH Terms: Animals, Azoxymethane, Carcinogenesis, Colitis, Ulcerative, Colon, Colonic Neoplasms, Cytokines, Dextran Sulfate, Inflammation, Macrophage Activation, Macrophages, Male, Mice, Ornithine Decarboxylase, Transcription, Genetic, Up-Regulation
Added June 15, 2018
0 Communities
2 Members
0 Resources
16 MeSH Terms
Helicobacter pylori pathogen regulates p14ARF tumor suppressor and autophagy in gastric epithelial cells.
Horvat A, Noto JM, Ramatchandirin B, Zaika E, Palrasu M, Wei J, Schneider BG, El-Rifai W, Peek RM, Zaika AI
(2018) Oncogene 37: 5054-5065
MeSH Terms: Antigens, Bacterial, Autophagy, Bacterial Proteins, Cell Line, Tumor, Down-Regulation, Epithelial Cells, Gastric Mucosa, HCT116 Cells, Helicobacter Infections, Helicobacter pylori, Humans, Signal Transduction, Stomach, Stomach Neoplasms, Tumor Suppressor Protein p14ARF, Tumor Suppressor Protein p53, Ubiquitin-Protein Ligases, Up-Regulation, Virulence Factors
Added September 25, 2018
0 Communities
1 Members
0 Resources
19 MeSH Terms
Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.
Mueller PA, Zhu L, Tavori H, Huynh K, Giunzioni I, Stafford JM, Linton MF, Fazio S
(2018) Circulation 138: 1850-1863
MeSH Terms: Animals, Aorta, Aortic Diseases, Apoptosis, Atherosclerosis, Cells, Cultured, Cholesterol, Disease Models, Animal, Female, Gene Deletion, Genetic Predisposition to Disease, Low Density Lipoprotein Receptor-Related Protein-1, Macrophages, Mice, Knockout, ApoE, Necrosis, Phenotype, Plaque, Atherosclerotic, Receptors, CCR7, Receptors, LDL, Signal Transduction, Tumor Suppressor Proteins, Up-Regulation
Added July 20, 2018
1 Communities
2 Members
0 Resources
22 MeSH Terms
lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer.
Wang Z, Yang B, Zhang M, Guo W, Wu Z, Wang Y, Jia L, Li S, Cancer Genome Atlas Research Network, Xie W, Yang D
(2018) Cancer Cell 33: 706-720.e9
MeSH Terms: Animals, Binding Sites, Breast Neoplasms, Cell Cycle, Cell Line, Tumor, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Humans, Mice, Neoplasm Transplantation, Prognosis, Promoter Regions, Genetic, Proto-Oncogene Proteins c-myc, RNA, Long Noncoding, Up-Regulation
Added October 30, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Intrinsic apoptotic pathway activation increases response to anti-estrogens in luminal breast cancers.
Williams MM, Lee L, Werfel T, Joly MMM, Hicks DJ, Rahman B, Elion D, McKernan C, Sanchez V, Estrada MV, Massarweh S, Elledge R, Duvall C, Cook RS
(2018) Cell Death Dis 9: 21
MeSH Terms: Aniline Compounds, Animals, Apoptosis, Breast Neoplasms, Cell Line, Tumor, Down-Regulation, Estrogen Antagonists, Female, Fulvestrant, Gene Targeting, Humans, Mice, Myeloid Cell Leukemia Sequence 1 Protein, Receptors, Estrogen, Signal Transduction, Sulfonamides, Up-Regulation, bcl-X Protein
Added March 14, 2018
0 Communities
2 Members
0 Resources
18 MeSH Terms
High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins.
Loh JT, Beckett AC, Scholz MB, Cover TL
(2018) Infect Immun 86:
MeSH Terms: Bacterial Outer Membrane Proteins, Gene Expression Regulation, Bacterial, Helicobacter Infections, Helicobacter pylori, Humans, Operon, Sodium Chloride, Transcription, Genetic, Up-Regulation
Added July 29, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Upregulation of SERT and ADORA1 in broilers with acute right ventricular failure.
Kamely M, Karimi Torshizi MA, Wideman RF, West J
(2019) Res Vet Sci 125: 397-400
MeSH Terms: Animals, Chickens, Cyclic Nucleotide Phosphodiesterases, Type 5, Gene Expression Regulation, Heart Failure, Hypertension, Pulmonary, Male, Myocardium, Poultry Diseases, Receptor, Adenosine A1, Serotonin Plasma Membrane Transport Proteins, Troponin T, Up-Regulation
Added April 2, 2019
0 Communities
1 Members
0 Resources
13 MeSH Terms
Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling.
Ahmad R, Kumar B, Chen Z, Chen X, Müller D, Lele SM, Washington MK, Batra SK, Dhawan P, Singh AB
(2017) Oncogene 36: 6592-6604
MeSH Terms: Adenocarcinoma, Animals, Carcinogenesis, Cell Transformation, Neoplastic, Claudin-3, Colon, Colonic Neoplasms, Colorectal Neoplasms, Cytokine Receptor gp130, Epigenesis, Genetic, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Humans, Intestinal Mucosa, Mice, Mice, Knockout, Permeability, STAT3 Transcription Factor, Up-Regulation, Wnt Signaling Pathway, beta Catenin
Added March 14, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
FSTL3 is increased in renal dysfunction.
Kralisch S, Hoffmann A, Klöting N, Bachmann A, Kratzsch J, Stolzenburg JU, Dietel A, Beige J, Anders M, Bast I, Blüher M, Zhang MZ, Harris RC, Stumvoll M, Fasshauer M, Ebert T
(2017) Nephrol Dial Transplant 32: 1637-1644
MeSH Terms: Aged, Aged, 80 and over, Animals, Case-Control Studies, Cells, Cultured, Cross-Sectional Studies, Female, Follistatin-Related Proteins, Gene Expression, Glomerular Filtration Rate, Humans, Insulin Resistance, Kidney, Liver, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Renal Insufficiency, Chronic, Up-Regulation
Added June 2, 2017
1 Communities
1 Members
0 Resources
21 MeSH Terms
Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients.
Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA
(2017) Gastroenterology 152: 1345-1357.e7
MeSH Terms: Adolescent, Area Under Curve, Case-Control Studies, Child, Colitis, Ulcerative, Colon, Crohn Disease, Female, Gene Expression, Humans, Immunity, Mucosal, Interleukin-13, Interleukin-13 Receptor alpha2 Subunit, Interleukin-17, Interleukin-23, Interleukin-5, Interleukins, Intestinal Mucosa, Male, Predictive Value of Tests, Prognosis, Prospective Studies, RNA, Messenger, ROC Curve, Rectum, Transcriptome, Up-Regulation
Added January 31, 2017
0 Communities
1 Members
0 Resources
27 MeSH Terms