Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression.
Camarillo JM, Rose KL, Galligan JJ, Xu S, Marnett LJ
(2016) Chem Res Toxicol 29
: 323-32MeSH Terms: Aldehydes, Cell Cycle Checkpoints, Cyclin-Dependent Kinase 2, Dose-Response Relationship, Drug, Humans, Models, Molecular, Structure-Activity Relationship, Tumor Cells, CulturedAdded April 14, 2017
8 MeSH Terms
Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis.
Soutto M, Chen Z, Katsha AM, Romero-Gallo J, Krishna US, Piazuelo MB, Washington MK, Peek RM, Belkhiri A, El-Rifai WM
(2015) Cancer 121
: 4348-58MeSH Terms: Adenocarcinoma, Animals, Carcinogenesis, Chemokine CXCL5, Gastric Mucosa, Helicobacter Infections, Helicobacter pylori, Humans, I-kappa B Kinase, In Vitro Techniques, Inflammation, Interleukin-1beta, Mice, Mice, Knockout, Peptides, Phosphorylation, Real-Time Polymerase Chain Reaction, Receptors, Interleukin-4, Stomach, Stomach Neoplasms, Transcription Factor RelA, Trefoil Factor-1, Tumor Cells, Cultured, Tumor Necrosis Factor-alphaAdded September 28, 2015
24 MeSH Terms
Sox10 Regulates Stem/Progenitor and Mesenchymal Cell States in Mammary Epithelial Cells.
Dravis C, Spike BT, Harrell JC, Johns C, Trejo CL, Southard-Smith EM, Perou CM, Wahl GM
(2015) Cell Rep 12
: 2035-48MeSH Terms: Animals, Breast Neoplasms, Cell Culture Techniques, Cell Differentiation, Epithelial Cells, Epithelial-Mesenchymal Transition, Female, Fetus, Fibroblast Growth Factors, Gene Expression Regulation, Developmental, Gene Expression Regulation, Neoplastic, Humans, Mammary Glands, Animal, Mammary Glands, Human, Mesenchymal Stem Cells, Mice, SOXE Transcription Factors, Signal Transduction, Spheroids, Cellular, Tumor Cells, CulturedAdded September 28, 2015
20 MeSH Terms
Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth.
Hover LD, Young CD, Bhola NE, Wilson AJ, Khabele D, Hong CC, Moses HL, Owens P
(2015) Cancer Lett 368
: 79-87MeSH Terms: Antineoplastic Agents, Bone Morphogenetic Protein Receptors, Bone Morphogenetic Proteins, Cell Proliferation, Cisplatin, Disease-Free Survival, Drug Resistance, Neoplasm, Female, Gene Expression Regulation, Neoplastic, Humans, Ovarian Neoplasms, Pyrazoles, Quinolines, Signal Transduction, Spheroids, Cellular, Tumor Cells, CulturedAdded August 4, 2015
16 MeSH Terms
Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation.
Gong Y, Ma Y, Sinyuk M, Loganathan S, Thompson RC, Sarkaria JN, Chen W, Lathia JD, Mobley BC, Clark SW, Wang J
(2016) Neuro Oncol 18
: 48-57MeSH Terms: Animals, Antigens, CD, Brain Neoplasms, Cell Proliferation, Cell Survival, Female, Glioblastoma, Humans, Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Mice, Nude, Proto-Oncogene Proteins c-akt, Receptor, IGF Type 1, Receptor, Insulin, Receptors, Somatomedin, Signal Transduction, Tumor Cells, CulturedAdded July 23, 2015
18 MeSH Terms
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Stewart ML, Tamayo P, Wilson AJ, Wang S, Chang YM, Kim JW, Khabele D, Shamji AF, Schreiber SL
(2015) Cancer Res 75
: 2897-906MeSH Terms: Animals, Azacitidine, Biomarkers, Tumor, Cystadenocarcinoma, Serous, Decitabine, Drug Resistance, Neoplasm, Female, Genes, ras, Humans, Mice, Mice, Nude, Mice, Transgenic, Mutation, Ovarian Neoplasms, Prognosis, Tumor Cells, Cultured, Xenograft Model Antitumor AssaysAdded February 22, 2016
17 MeSH Terms
Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies.
Wirtz ED, Hoshino D, Maldonado AT, Tyson DR, Weaver AM
(2015) JAMA Otolaryngol Head Neck Surg 141
: 543-9MeSH Terms: Benzoquinones, Carcinoma, Squamous Cell, Cell Line, Tumor, Cell Survival, Class I Phosphatidylinositol 3-Kinases, Head and Neck Neoplasms, Humans, Imidazoles, Indazoles, Inhibitory Concentration 50, Lactams, Macrocyclic, Molecular Targeted Therapy, Mutation, Phosphatidylinositol 3-Kinases, Protein-Serine-Threonine Kinases, Pyridones, Pyrimidinones, Quinolines, Squamous Cell Carcinoma of Head and Neck, Sulfonamides, TOR Serine-Threonine Kinases, Tumor Cells, CulturedAdded February 15, 2016
22 MeSH Terms
Stretching fibroblasts remodels fibronectin and alters cancer cell migration.
Ao M, Brewer BM, Yang L, Franco Coronel OE, Hayward SW, Webb DJ, Li D
(2015) Sci Rep 5
: 8334MeSH Terms: Cell Movement, Fibroblasts, Fibronectins, Humans, Male, Neoplasm Proteins, Prostatic Neoplasms, Receptor, Platelet-Derived Growth Factor beta, Signal Transduction, Tumor Cells, CulturedAdded February 19, 2015
10 MeSH Terms
Quantitative chemoproteomics for site-specific analysis of protein alkylation by 4-hydroxy-2-nonenal in cells.
Yang J, Tallman KA, Porter NA, Liebler DC
(2015) Anal Chem 87
: 2535-41MeSH Terms: Aldehydes, Alkylation, Chromatography, Liquid, Colorectal Neoplasms, Cross-Linking Reagents, Humans, Neoplasm Proteins, Protein Processing, Post-Translational, Tandem Mass Spectrometry, Tumor Cells, CulturedAdded February 15, 2016
10 MeSH Terms
Dimerization and phosphatase activity of calcyclin-binding protein/Siah-1 interacting protein: the influence of oxidative stress.
Topolska-Woś AM, Shell SM, Kilańczyk E, Szczepanowski RH, Chazin WJ, Filipek A
(2015) FASEB J 29
: 1711-24MeSH Terms: Amino Acid Sequence, Animals, Blotting, Western, Calcium-Binding Proteins, Flow Cytometry, Fluorescent Antibody Technique, Immunoprecipitation, Mice, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Molecular Sequence Data, Neuroblastoma, Oxidative Stress, Phosphorylation, Protein Conformation, Protein Multimerization, Protein Processing, Post-Translational, Proteins, Scattering, Small Angle, Sequence Homology, Amino Acid, Spectroscopy, Fourier Transform Infrared, Tumor Cells, Cultured, Ubiquitin-Protein LigasesAdded February 5, 2016
23 MeSH Terms