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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 26

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Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.
Behr ER, Ritchie MD, Tanaka T, Kääb S, Crawford DC, Nicoletti P, Floratos A, Sinner MF, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Zumhagen S, Guicheney P, Bishopric NH, Marshall V, Shakir S, Dalageorgou C, Bevan S, Jamshidi Y, Bastiaenen R, Myerburg RJ, Schott JJ, Camm AJ, Steinbeck G, Norris K, Altman RB, Tatonetti NP, Jeffery S, Kubo M, Nakamura Y, Shen Y, George AL, Roden DM
(2013) PLoS One 8: e78511
MeSH Terms: Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Child, European Continental Ancestry Group, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Torsades de Pointes
Added March 7, 2014
0 Communities
2 Members
0 Resources
21 MeSH Terms
QT variability during initial exposure to sotalol: experience based on a large electronic medical record.
Weeke P, Delaney J, Mosley JD, Wells Q, Van Driest S, Norris K, Kucera G, Stubblefield T, Roden DM
(2013) Europace 15: 1791-7
MeSH Terms: Adrenergic beta-Antagonists, Aged, Anti-Arrhythmia Agents, Electronic Health Records, Female, Heart Conduction System, Humans, Linear Models, Logistic Models, Long QT Syndrome, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Assessment, Risk Factors, Sotalol, Time Factors, Torsades de Pointes
Added February 28, 2014
0 Communities
3 Members
0 Resources
19 MeSH Terms
Drug-induced arrhythmia: pharmacogenomic prescribing?
Behr ER, Roden D
(2013) Eur Heart J 34: 89-95
MeSH Terms: Anti-Arrhythmia Agents, Electrocardiography, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Ion Channels, Long QT Syndrome, Polymorphism, Genetic, Risk Factors, Torsades de Pointes
Added June 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes.
Behr ER, January C, Schulze-Bahr E, Grace AA, Kääb S, Fiszman M, Gathers S, Buckman S, Youssef A, Pirmohamed M, Roden D
(2013) Eur Heart J 34: 1958-63
MeSH Terms: Adverse Drug Reaction Reporting Systems, Anti-Arrhythmia Agents, Anti-Infective Agents, Antipsychotic Agents, Consensus, Consensus Development Conferences as Topic, Drug-Related Side Effects and Adverse Reactions, Genetic Markers, Genetic Testing, Histamine Antagonists, Humans, Interprofessional Relations, Phenotype, Risk Factors, Sex Factors, Torsades de Pointes
Added June 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.
Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER
(2012) J Am Coll Cardiol 60: 841-50
MeSH Terms: Adaptor Proteins, Signal Transducing, Adult, Aged, Aged, 80 and over, Amiodarone, Anti-Arrhythmia Agents, Case-Control Studies, Female, Humans, Long QT Syndrome, Male, Middle Aged, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Torsades de Pointes, Ventricular Fibrillation, Young Adult
Added June 26, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.
Ramirez AH, Shaffer CM, Delaney JT, Sexton DP, Levy SE, Rieder MJ, Nickerson DA, George AL, Roden DM
(2013) Pharmacogenomics J 13: 325-9
MeSH Terms: Adolescent, Adult, Aged, Arrhythmias, Cardiac, Drug-Related Side Effects and Adverse Reactions, Electrocardiography, Female, Gene Frequency, Heart Rate, Humans, Long QT Syndrome, Male, Middle Aged, Polymorphism, Single Nucleotide, Torsades de Pointes
Added August 16, 2012
1 Communities
1 Members
0 Resources
15 MeSH Terms
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.
Kääb S, Crawford DC, Sinner MF, Behr ER, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Guicheney P, Bishopric NH, Myerburg RJ, Schott JJ, Pfeufer A, Beckmann BM, Martens E, Zhang T, Stallmeyer B, Zumhagen S, Denjoy I, Bardai A, Van Gelder IC, Jamshidi Y, Dalageorgou C, Marshall V, Jeffery S, Shakir S, Camm AJ, Steinbeck G, Perz S, Lichtner P, Meitinger T, Peters A, Wichmann HE, Ingram C, Bradford Y, Carter S, Norris K, Ritchie MD, George AL, Roden DM
(2012) Circ Cardiovasc Genet 5: 91-9
MeSH Terms: Aged, Aged, 80 and over, Alleles, Amino Acid Substitution, Anti-Arrhythmia Agents, Case-Control Studies, Cohort Studies, Female, Genotype, Haplotypes, Humans, Long QT Syndrome, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Potassium, Potassium Channels, Voltage-Gated, Torsades de Pointes
Added August 16, 2012
1 Communities
1 Members
0 Resources
19 MeSH Terms
The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions.
Pirmohamed M, Aithal GP, Behr E, Daly A, Roden D
(2011) Clin Pharmacol Ther 89: 784-5
MeSH Terms: Chemical and Drug Induced Liver Injury, Consensus Development Conferences as Topic, Drug-Related Side Effects and Adverse Reactions, Humans, Pharmaceutical Preparations, Pharmacogenetics, Phenotype, Skin Diseases, Torsades de Pointes
Added June 26, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Drug-induced long QT syndrome.
Kannankeril P, Roden DM, Darbar D
(2010) Pharmacol Rev 62: 760-81
MeSH Terms: Animals, Delayed Rectifier Potassium Channels, Drug-Related Side Effects and Adverse Reactions, Humans, Long QT Syndrome, Risk Factors, Torsades de Pointes
Added June 26, 2014
0 Communities
1 Members
0 Resources
7 MeSH Terms
Sotalol-induced torsades de pointes precipitated during treatment with oseltamivir for H1N1 influenza.
Wells Q, Hardin B, Raj SR, Darbar D
(2010) Heart Rhythm 7: 1454-7
MeSH Terms: Aged, Anti-Arrhythmia Agents, Antiviral Agents, Drug Interactions, Electrocardiography, Female, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Middle Aged, Oseltamivir, Sotalol, Torsades de Pointes
Added February 28, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms