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Results: 11 to 20 of 164

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Applied pharmacogenomics in cardiovascular medicine.
Weeke P, Roden DM
(2014) Annu Rev Med 65: 81-94
MeSH Terms: Adrenergic beta-Antagonists, Antihypertensive Agents, Antithrombins, Aryl Hydrocarbon Hydroxylases, Cardiovascular Diseases, Clopidogrel, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP2C9, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Liver-Specific Organic Anion Transporter 1, Organic Anion Transporters, Pharmacogenetics, Polymorphism, Single Nucleotide, Precision Medicine, Ticlopidine, Vitamin K Epoxide Reductases, Warfarin
Added March 7, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation.
Aldrovandi M, Hammond VJ, Podmore H, Hornshaw M, Clark SR, Marnett LJ, Slatter DA, Murphy RC, Collins PW, O'Donnell VB
(2013) J Lipid Res 54: 3085-97
MeSH Terms: Aspirin, Blood Platelets, Calcium, Cyclooxygenase 1, Cyclooxygenase Inhibitors, Dinoprostone, Dose-Response Relationship, Drug, Esterification, Feedback, Physiological, Humans, Intracellular Space, MAP Kinase Kinase 1, Phosphatidylethanolamines, Phospholipids, Platelet Activation, Prostaglandin D2, Prostaglandins, Protein Kinase C, Receptor, PAR-1, Thrombin, src-Family Kinases
Added March 7, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.
Yeung J, Apopa PL, Vesci J, Stolla M, Rai G, Simeonov A, Jadhav A, Fernandez-Perez P, Maloney DJ, Boutaud O, Holman TR, Holinstat M
(2013) Thromb Haemost 110: 569-81
MeSH Terms: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid, Animals, Arachidonate 12-Lipoxygenase, Blood Platelets, Cyclooxygenase 1, Eicosanoids, Flow Cytometry, Humans, Mice, Mice, Transgenic, Platelet Activation, Platelet Adhesiveness, Platelet Aggregation, Platelet Membrane Glycoproteins, Receptors, Thrombin, Thrombosis, Time Factors
Added March 27, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human platelets.
Young SE, Duvernay MT, Schulte ML, Lindsley CW, Hamm HE
(2013) PLoS One 8: e65528
MeSH Terms: Adult, Blood Platelets, Female, Fibrinolytic Agents, Humans, Indazoles, Indoles, Male, Platelet Activation, Receptors, Thrombin
Added December 10, 2013
0 Communities
1 Members
0 Resources
10 MeSH Terms
Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.
Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ
(2013) J Thromb Haemost 11: 1341-52
MeSH Terms: Animals, Antibodies, Neutralizing, Blood Coagulation, Factor XI, Factor XI Deficiency, Factor XII, Factor XIIa, Factor XIa, Humans, Plant Proteins, Polyphosphates, Prothrombin, Thrombin, Thrombosis, Time Factors
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability.
Zebda N, Tian Y, Tian X, Gawlak G, Higginbotham K, Reynolds AB, Birukova AA, Birukov KG
(2013) J Biol Chem 288: 18290-9
MeSH Terms: Adherens Junctions, Antigens, CD, Binding Sites, Blotting, Western, Cadherins, Catenins, Cell Membrane, Cell Membrane Permeability, Cells, Cultured, Cytoskeleton, Endothelial Cells, Fluorescent Antibody Technique, GTPase-Activating Proteins, Guanine Nucleotide Exchange Factors, HEK293 Cells, Humans, Mutation, Phosphatidylcholines, Protein Binding, Protein Interaction Mapping, Repressor Proteins, Thrombin, p21-Activated Kinases, rac1 GTP-Binding Protein
Added March 7, 2014
1 Communities
1 Members
0 Resources
24 MeSH Terms
The leading role of microtubules in endothelial barrier dysfunction: disassembly of peripheral microtubules leaves behind the cytoskeletal reorganization.
Alieva IB, Zemskov EA, Smurova KM, Kaverina IN, Verin AD
(2013) J Cell Biochem 114: 2258-72
MeSH Terms: Cytoskeleton, Electric Impedance, Endothelium, Vascular, Fluorescent Antibody Technique, Humans, Microtubules, Pulmonary Artery, Thrombin
Added December 10, 2013
0 Communities
1 Members
0 Resources
8 MeSH Terms
Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.
Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP
(2013) Arterioscler Thromb Vasc Biol 33: 1670-8
MeSH Terms: Animals, Antibodies, Monoclonal, Arteriovenous Shunt, Surgical, Bleeding Time, Blood Coagulation, Collagen, Disease Models, Animal, Dose-Response Relationship, Drug, Down-Regulation, Factor XI, Fibrinolytic Agents, Hemorrhage, Macaca fascicularis, Oligonucleotides, Antisense, Papio, Thrombin, Thrombosis, Time Factors
Added May 19, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets.
Duvernay M, Young S, Gailani D, Schoenecker J, Hamm HE, Hamm H
(2013) Mol Pharmacol 83: 781-92
MeSH Terms: Blood Platelets, Factor V, Gene Expression Regulation, Humans, Receptor, PAR-1, Receptors, Thrombin, Thrombin
Added December 10, 2013
1 Communities
3 Members
0 Resources
7 MeSH Terms
Effect of zymogen domains and active site occupation on activation of prothrombin by von Willebrand factor-binding protein.
Kroh HK, Bock PE
(2012) J Biol Chem 287: 39149-57
MeSH Terms: Binding, Competitive, Blood Coagulation, Carrier Proteins, Catalytic Domain, Enzyme Precursors, Fibrin, HEK293 Cells, Humans, Kinetics, Platelet Membrane Glycoproteins, Protein Binding, Protein Conformation, Protein Structure, Tertiary, Prothrombin, Recombinant Proteins, Staphylococcus aureus, Thermodynamics, Thrombin, Virulence Factors, von Willebrand Factor
Added January 20, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms