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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 113

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Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system.
Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR
(2016) Nature 537: 234-238
MeSH Terms: Animals, Antibodies, B-Lymphocytes, Cell Hypoxia, Cell Proliferation, Cell Survival, Cytosine Deaminase, Germinal Center, Hypoxia, Immunoglobulin Class Switching, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Inbred C57BL, Multiprotein Complexes, TOR Serine-Threonine Kinases
Added August 9, 2016
1 Communities
3 Members
0 Resources
15 MeSH Terms
Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.
Morrison Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov dos D, Muller WJ, Brantley-Sieders D, Cook RS
(2016) Cancer Res 76: 4752-64
MeSH Terms: Animals, Blotting, Western, Breast Neoplasms, Carrier Proteins, Disease Progression, Drug Resistance, Neoplasm, Female, Heterografts, Humans, Kaplan-Meier Estimate, Mechanistic Target of Rapamycin Complex 2, Mice, Mice, Inbred BALB C, Mice, Nude, Multiprotein Complexes, Rapamycin-Insensitive Companion of mTOR Protein, Receptor, ErbB-2, Signal Transduction, TOR Serine-Threonine Kinases, Tissue Array Analysis
Added April 15, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines.
Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Sandoval A, Bizama C, Araya JC, Peek RM, Roa JC
(2016) Pathol Oncol Res 22: 797-805
MeSH Terms: Adaptor Proteins, Signal Transducing, Cell Cycle Proteins, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Gene Expression, Humans, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Phosphoproteins, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 70-kDa, Signal Transduction, Stomach Neoplasms, TOR Serine-Threonine Kinases
Added April 6, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Kishton RJ, Barnes CE, Nichols AG, Cohen S, Gerriets VA, Siska PJ, Macintyre AN, Goraksha-Hicks P, de Cubas AA, Liu T, Warmoes MO, Abel ED, Yeoh AE, Gershon TR, Rathmell WK, Richards KL, Locasale JW, Rathmell JC
(2016) Cell Metab 23: 649-62
MeSH Terms: AMP-Activated Protein Kinases, Animals, Cell Line, Tumor, Cell Survival, Glycolysis, Humans, Mechanistic Target of Rapamycin Complex 1, Mice, Inbred C57BL, Mitochondria, Multiprotein Complexes, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Receptors, Notch, Signal Transduction, Stress, Physiological, T-Lymphocytes, TOR Serine-Threonine Kinases
Added August 8, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.
Liu D, Bordicchia M, Zhang C, Fang H, Wei W, Li JL, Guilherme A, Guntur K, Czech MP, Collins S
(2016) J Clin Invest 126: 1704-16
MeSH Terms: 3T3-L1 Cells, Adaptor Proteins, Signal Transducing, Adipose Tissue, Brown, Adipose Tissue, White, Animals, Cyclic AMP-Dependent Protein Kinases, HEK293 Cells, Humans, Insulin, Mechanistic Target of Rapamycin Complex 1, Mice, Mice, Knockout, Multiprotein Complexes, Receptors, Adrenergic, beta, Regulatory-Associated Protein of mTOR, Ribosomal Protein S6 Kinases, 70-kDa, Ribosomal Protein S6 Kinases, 90-kDa, Signal Transduction, TOR Serine-Threonine Kinases, Uncoupling Protein 1
Added July 22, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I
(2016) Nat Med 22: 412-20
MeSH Terms: Aging, Animals, Cell Proliferation, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Fibroblasts, Gene Expression Regulation, Glucose, Humans, Insulin, Insulin Secretion, Insulin-Secreting Cells, Mice, Mice, Transgenic, PPAR gamma, TOR Serine-Threonine Kinases
Added March 17, 2016
2 Communities
2 Members
0 Resources
16 MeSH Terms
Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons.
Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN
(2016) Neuron 89: 741-55
MeSH Terms: Animals, Animals, Genetically Modified, Cell Communication, Dendrites, Drosophila, Drosophila Proteins, Epidermis, Focal Adhesion Kinase 1, Gene Expression Regulation, Developmental, Green Fluorescent Proteins, Immunoprecipitation, Larva, Mechanistic Target of Rapamycin Complex 2, Molecular Biology, Multiprotein Complexes, Mutation, Nerve Tissue Proteins, Receptors, Cell Surface, Semaphorins, Sensory Receptor Cells, TOR Serine-Threonine Kinases, Transfection
Added February 9, 2016
1 Communities
0 Members
0 Resources
22 MeSH Terms
Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.
Babaev VR, Ding L, Zhang Y, May JM, Lin PC, Fazio S, Linton MF
(2016) Arterioscler Thromb Vasc Biol 36: 598-607
MeSH Terms: Animals, Apoptosis, Atherosclerosis, Cell Survival, Cells, Cultured, Diet, Western, Disease Models, Animal, Female, I-kappa B Kinase, Inflammation Mediators, Liver, Liver Transplantation, Macrophages, Peritoneal, Male, Mechanistic Target of Rapamycin Complex 2, Mice, Inbred C57BL, Mice, Knockout, Multiprotein Complexes, Phosphorylation, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-akt, Receptors, LDL, Signal Transduction, TOR Serine-Threonine Kinases, Time Factors
Added February 22, 2016
0 Communities
2 Members
0 Resources
25 MeSH Terms
Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.
Coffey RT, Shi Y, Long MJ, Marr MT, Hedstrom L
(2016) J Biol Chem 291: 5221-33
MeSH Terms: Adaptor Proteins, Signal Transducing, Arginine, Carbamates, Cell Cycle Proteins, Cell Line, Tumor, Cell Proliferation, Enzyme Inhibitors, HEK293 Cells, Humans, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Phosphoproteins, Phosphorylation, Protein Binding, Protein Biosynthesis, Protein Processing, Post-Translational, Ribosomal Protein S6 Kinases, Signal Transduction, TOR Serine-Threonine Kinases, Ubiquitins
Added May 9, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population.
Bhola NE, Jansen VM, Koch JP, Li H, Formisano L, Williams JA, Grandis JR, Arteaga CL
(2016) Cancer Res 76: 440-52
MeSH Terms: Cell Line, Tumor, Drug Resistance, Neoplasm, Humans, Mechanistic Target of Rapamycin Complex 2, Multiprotein Complexes, Neoplastic Stem Cells, Signal Transduction, TOR Serine-Threonine Kinases, Triple Negative Breast Neoplasms, Xenograft Model Antitumor Assays
Added March 10, 2016
0 Communities
1 Members
0 Resources
10 MeSH Terms