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Results: 11 to 20 of 51

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Reactivities and products of free radical oxidation of cholestadienols.
Xu L, Porter NA
(2014) J Am Chem Soc 136: 5443-50
MeSH Terms: Dehydrocholesterols, Free Radicals, Molecular Conformation, Oxidation-Reduction
Added March 20, 2014
0 Communities
1 Members
0 Resources
4 MeSH Terms
A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome.
Liu W, Xu L, Lamberson C, Haas D, Korade Z, Porter NA
(2014) J Lipid Res 55: 329-37
MeSH Terms: Animals, Blood Chemical Analysis, Cell Line, Tumor, Dehydrocholesterols, Heterozygote, Humans, Mice, Nervous System, Smith-Lemli-Opitz Syndrome, Triazoles
Added March 20, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.
Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK
(2013) J Biol Chem 288: 35812-23
MeSH Terms: Animals, Bone Marrow Cells, Cholesterol Esters, Gene Expression Profiling, Hydroxycholesterols, Liver X Receptors, Macrophages, Mice, Mice, Inbred C57BL, Muromegalovirus, Orphan Nuclear Receptors, Oxidative Stress, Protein Biosynthesis, Signal Transduction, Sphingolipids, Sterol Regulatory Element Binding Proteins, Transcription, Genetic
Added March 7, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome.
Windsor K, Genaro-Mattos TC, Kim HY, Liu W, Tallman KA, Miyamoto S, Korade Z, Porter NA
(2013) J Lipid Res 54: 2842-50
MeSH Terms: Cell Line, Tumor, Cytochromes c, Dehydrocholesterols, Fatty Acids, Unsaturated, Humans, Lipoylation, Oxidation-Reduction, Phospholipids, Protein Processing, Post-Translational, Proteome, Smith-Lemli-Opitz Syndrome
Added March 7, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells.
Wang SF, Chou YC, Mazumder N, Kao FJ, Nagy LD, Guengerich FP, Huang C, Lee HC, Lai PS, Ueng YF
(2013) Biochem Pharmacol 86: 548-60
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1, Acetylcysteine, Antibiotics, Antineoplastic, Antioxidants, Carcinoma, Hepatocellular, Cell Line, Cell Line, Tumor, Cell Survival, Cholesterol, Doxorubicin, Drug Resistance, Neoplasm, Hepatocytes, Humans, Hydroxycholesterols, Ketocholesterols, Lactic Acid, Oligomycins, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Signal Transduction, TOR Serine-Threonine Kinases, Up-Regulation
Added March 7, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
A perspective on free radical autoxidation: the physical organic chemistry of polyunsaturated fatty acid and sterol peroxidation.
Porter NA
(2013) J Org Chem 78: 3511-24
MeSH Terms: Chemistry, Physical, Dehydrocholesterols, Fatty Acids, Unsaturated, Free Radicals, Heterocyclic Oxides, Humans, Oxidative Stress, Peroxides, Sterols
Added March 7, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.
Xu L, Korade Z, Rosado DA, Mirnics K, Porter NA
(2013) J Lipid Res 54: 1135-43
MeSH Terms: Animals, Cell Line, Cells, Cultured, Chromatography, High Pressure Liquid, Dehydrocholesterols, Fibroblasts, Humans, Lipid Metabolism, Mass Spectrometry, Mice, Mice, Knockout, Oxidation-Reduction, Oxidoreductases Acting on CH-CH Group Donors, Tandem Mass Spectrometry
Added March 7, 2014
0 Communities
2 Members
0 Resources
14 MeSH Terms
Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients.
Liu W, Xu L, Lamberson CR, Merkens LS, Steiner RD, Elias ER, Haas D, Porter NA
(2013) J Lipid Res 54: 244-53
MeSH Terms: Adolescent, Adult, Blood Chemical Analysis, Blood Specimen Collection, Child, Child, Preschool, Chromatography, High Pressure Liquid, Dehydrocholesterols, Esters, Female, Humans, Infant, Male, Oxidation-Reduction, Smith-Lemli-Opitz Syndrome, Tandem Mass Spectrometry, Young Adult
Added March 20, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome.
Korade Z, Xu L, Mirnics K, Porter NA
(2013) J Inherit Metab Dis 36: 113-22
MeSH Terms: Animals, Biomarkers, Brain, Dehydrocholesterols, Disease Models, Animal, Lipid Peroxidation, Liver, Mice, Mice, Knockout, Oxidation-Reduction, Oxidative Stress, Smith-Lemli-Opitz Syndrome
Added March 7, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.
Xu L, Sheflin LG, Porter NA, Fliesler SJ
(2012) Biochim Biophys Acta 1821: 877-83
MeSH Terms: Animals, Animals, Newborn, Cholesterol, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Female, Humans, Ketocholesterols, Male, Mass Spectrometry, Molecular Structure, Pregnancy, Rats, Rats, Sprague-Dawley, Retina, Retinal Degeneration, Smith-Lemli-Opitz Syndrome, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Added March 20, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms