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Results: 11 to 20 of 73

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Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription.
Sewer MB, Nguyen VQ, Huang CJ, Tucker PW, Kagawa N, Waterman MR
(2002) Endocrinology 143: 1280-90
MeSH Terms: Adrenal Cortex, Amino Acid Sequence, Blotting, Western, Cell Nucleus, Cells, Cultured, Cycloheximide, DNA-Binding Proteins, Fushi Tarazu Transcription Factors, Gene Expression Regulation, Enzymologic, Histone Deacetylases, Homeodomain Proteins, Humans, Immunoenzyme Techniques, Molecular Sequence Data, Nuclear Proteins, Plasmids, Promoter Regions, Genetic, Protein Synthesis Inhibitors, Receptors, Cytoplasmic and Nuclear, Serine-Arginine Splicing Factors, Steroid 17-alpha-Hydroxylase, Steroidogenic Factor 1, Transcription Factors, Transcription, Genetic, Transcriptional Activation
Added February 12, 2015
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25 MeSH Terms
The use of random chimeragenesis to study structure/function properties of rat and human P450c17.
Brock BJ, Waterman MR
(2000) Arch Biochem Biophys 373: 401-8
MeSH Terms: Animals, Enzyme Stability, Humans, Hydrogen Peroxide, Microsomes, Progesterone, Protein Structure, Secondary, Rats, Recombinant Fusion Proteins, Spectrophotometry, Steroid 17-alpha-Hydroxylase, Structure-Activity Relationship
Added February 12, 2015
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12 MeSH Terms
Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species.
Brock BJ, Waterman MR
(1999) Biochemistry 38: 1598-606
MeSH Terms: 17-alpha-Hydroxyprogesterone, Animals, Cattle, Cytochromes b5, Enzyme Activation, Enzyme Stability, Heme, Humans, Hydrogen Peroxide, Progesterone, Rats, Recombinant Proteins, Species Specificity, Steroid 17-alpha-Hydroxylase, Steroids, Substrate Specificity
Added February 12, 2015
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16 MeSH Terms
The bovine CYP17 promoter contains a transcriptional regulatory element cooperatively bound by tale homeodomain proteins.
Bischof LJ, Kagawa N, Waterman MR
(1998) Endocr Res 24: 489-95
MeSH Terms: Animals, Binding Sites, Cattle, Cyclic AMP Response Element-Binding Protein, DNA-Binding Proteins, Homeodomain Proteins, Mice, Myeloid Ecotropic Viral Integration Site 1 Protein, Neoplasm Proteins, Pre-B-Cell Leukemia Transcription Factor 1, Promoter Regions, Genetic, Proto-Oncogene Proteins, Recombinant Proteins, Reticulocytes, Steroid 17-alpha-Hydroxylase, Steroidogenic Factor 1, Transcription Factors, Tumor Cells, Cultured
Added February 12, 2015
0 Communities
1 Members
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18 MeSH Terms
NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase.
Jenkins CM, Waterman MR
(1998) Biochemistry 37: 6106-13
MeSH Terms: Animals, Cattle, Electron Transport, Escherichia coli, Flavodoxin, Microsomes, NADH, NADPH Oxidoreductases, NADPH-Ferrihemoprotein Reductase, Rats, Recombinant Proteins, Solubility, Spectrophotometry, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
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13 MeSH Terms
Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17.
Bischof LJ, Kagawa N, Moskow JJ, Takahashi Y, Iwamatsu A, Buchberg AM, Waterman MR
(1998) J Biol Chem 273: 7941-8
MeSH Terms: Amino Acid Sequence, Animals, Binding Sites, Cattle, Cyclic AMP Response Element-Binding Protein, DNA-Binding Proteins, Homeodomain Proteins, Molecular Sequence Data, Myeloid Ecotropic Viral Integration Site 1 Protein, Neoplasm Proteins, Pre-B-Cell Leukemia Transcription Factor 1, Protein Binding, Proto-Oncogene Proteins, Sequence Alignment, Sequence Analysis, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
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16 MeSH Terms
The homeodomain protein Pbx1 is involved in cAMP-dependent transcription of human CYP17.
Ogo A, Waterman MR, McAllister JM, Kagawa N
(1997) Arch Biochem Biophys 348: 226-31
MeSH Terms: Adrenal Glands, Animals, Base Sequence, Binding Sites, Cattle, Cell Line, Consensus Sequence, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, DNA-Binding Proteins, Genes, Reporter, Homeodomain Proteins, Humans, Luciferases, Oligodeoxyribonucleotides, Pre-B-Cell Leukemia Transcription Factor 1, Promoter Regions, Genetic, Proto-Oncogene Proteins, Recombinant Fusion Proteins, Sequence Deletion, Steroid 17-alpha-Hydroxylase, Transcription, Genetic, Transcriptional Activation, Transfection, Tumor Cells, Cultured
Added February 12, 2015
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25 MeSH Terms
Escherichia coli flavodoxin sepharose as an affinity resin for cytochromes P450 and use to identify a putative cytochrome P450c17/3beta-hydroxysteroid dehydrogenase interaction.
Jenkins CM, Pikuleva I, Kagawa N, Waterman MR
(1997) Arch Biochem Biophys 347: 93-102
MeSH Terms: 3-Hydroxysteroid Dehydrogenases, Adrenal Cortex, Animals, Cattle, Chromatography, Affinity, Cloning, Molecular, Cytochrome P-450 Enzyme System, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Flavodoxin, Immunoblotting, Peptide Fragments, Protein Binding, Recombinant Proteins, Sepharose, Steroid 17-alpha-Hydroxylase, Steroid 21-Hydroxylase, Steroids
Added February 12, 2015
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18 MeSH Terms
Negatively charged anabaena flavodoxin residues (Asp144 and Glu145) are important for reconstitution of cytochrome P450 17alpha-hydroxylase activity.
Jenkins CM, Genzor CG, Fillat MF, Waterman MR, Gómez-Moreno C
(1997) J Biol Chem 272: 22509-13
MeSH Terms: Amino Acid Sequence, Anabaena, Aspartic Acid, Cytochrome P-450 Enzyme System, Flavodoxin, Glutamic Acid, Molecular Sequence Data, Mutagenesis, Site-Directed, Protein Conformation, Sequence Homology, Amino Acid, Steroid 17-alpha-Hydroxylase
Added February 12, 2015
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11 MeSH Terms
Developmentally regulated expression and activity of 17alpha-hydroxylase/C-17,20-lyase cytochrome P450 in rat liver.
Vianello S, Waterman MR, Dalla Valle L, Colombo L
(1997) Endocrinology 138: 3166-74
MeSH Terms: Androgens, Animals, Base Sequence, Blotting, Northern, Cell Division, Cytochrome P-450 Enzyme System, DNA Primers, Duodenum, Female, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, Granulosa Cells, Liver, Male, Polymerase Chain Reaction, RNA, Messenger, Rats, Rats, Wistar, Sertoli Cells, Steroid 17-alpha-Hydroxylase, Stomach, Testis, Time Factors
Added February 12, 2015
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23 MeSH Terms