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Results: 11 to 15 of 15

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Dissociation of spatial attention and saccade preparation.
Juan CH, Shorter-Jacobi SM, Schall JD
(2004) Proc Natl Acad Sci U S A 101: 15541-4
MeSH Terms: Animals, Attention, Electric Stimulation, Macaca, Reaction Time, Saccades, Spatial Behavior, Species Specificity
Show Abstract · Added February 12, 2015
The goal of this experiment was to determine whether the allocation of attention necessarily requires saccade preparation. To dissociate the focus of attention from the endpoint of a saccade, macaque monkeys were trained to perform visual search for a uniquely colored rectangle and shift gaze either toward or opposite this color singleton according to its orientation. A vertical singleton cued a prosaccade, a horizontal singleton, an antisaccade. Saccade preparation was probed by measuring the direction of saccades evoked by intracortical microstimulation of the frontal eye fields at variable times after presentation of the search array. Eye movements evoked on prosaccade trials deviated progressively toward the singleton that was also the endpoint of the correct eye movement. However, eye movements evoked on antisaccade trials never deviated toward the singleton but only progressively toward the location opposite the singleton. This occurred even though previous work showed that on antisaccade trials most neurons in frontal eye fields initially select the singleton while attention is allocated to distinguish its shape. Thus, sensorimotor structures can covertly orient attention without preparing a saccade.
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8 MeSH Terms
The role of the parietal cortex in visual feature binding.
Shafritz KM, Gore JC, Marois R
(2002) Proc Natl Acad Sci U S A 99: 10917-22
MeSH Terms: Adult, Female, Humans, Male, Memory, Short-Term, Parietal Lobe, Spatial Behavior, Task Performance and Analysis, Visual Perception
Show Abstract · Added December 10, 2013
When multiple objects are simultaneously present in a scene, the visual system must properly integrate the features associated with each object. It has been proposed that this "binding problem" is solved by selective attention to the locations of the objects [Treisman, A.M. & Gelade, E. (1980) Cogn. Psychol. 12, 97-136]. If spatial attention plays a role in feature integration, it should do so primarily when object location can serve as a binding cue. Using functional MRI (fMRI), we show that regions of the parietal cortex involved in spatial attention are more engaged in feature conjunction tasks than in single feature tasks when multiple objects are shown simultaneously at different locations but not when they are shown sequentially at the same location. These findings suggest that the spatial attention network of the parietal cortex is involved in feature binding but only when spatial information is available to resolve ambiguities about the relationships between object features.
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9 MeSH Terms
Critical periods for the effects of alcohol exposure on learning in rats.
Cronise K, Marino MD, Tran TD, Kelly SJ
(2001) Behav Neurosci 115: 138-45
MeSH Terms: Age Factors, Animals, Behavior, Animal, Critical Period, Psychological, Ethanol, Female, Male, Maze Learning, Rats, Rats, Long-Evans, Sex Factors, Spatial Behavior
Show Abstract · Added January 22, 2015
Critical periods for alcohol-induced deficits in spatial navigation and passive avoidance learning were investigated with a rat model of fetal alcohol syndrome. Rats were exposed to alcohol prenatally (Gestational Days 1-10 or 11-22) or postnatally (Postnatal Days 2-10) or throughout all 3 periods. Offspring were tested in either a spatial navigation or an avoidance task as juveniles or adults. As juveniles, the combined exposure group took longer to learn the spatial navigation task compared with all other groups. This effect was not seen in adults. Passive avoidance performance was not affected. These results suggest that long-term exposure to alcohol during development has adverse effects on spatial learning. The lack of differences in the short-term exposure groups implies that there may not be 1 critical period of alcohol exposure, but that the adverse effects of alcohol during development may be cumulative on some behaviors.
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12 MeSH Terms
Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function.
Paradee W, Melikian HE, Rasmussen DL, Kenneson A, Conn PJ, Warren ST
(1999) Neuroscience 94: 185-92
MeSH Terms: Amygdala, Animals, Conditioning, Psychological, Electrophysiology, Fear, Female, Fragile X Mental Retardation Protein, Fragile X Syndrome, Genotype, Hippocampus, Long-Term Potentiation, Male, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins, Phenotype, RNA-Binding Proteins, Spatial Behavior
Show Abstract · Added February 19, 2015
Fragile X syndrome is an X-linked form of mental retardation resulting from the absence of expression of the fragile X mental retardation 1 gene. The encoded protein is a ribosome-associated, RNA-binding protein thought to play a role in translational regulation of selective messenger RNA transcripts. A knockout mouse has been described that exhibits subtle deficits in spatial learning but normal early-phase long-term potentiation. We expanded these studies by examination of late-phase hippocampal long-term potentiation, the protein synthesis-dependent form of long-term potentiation, in the Fmrl knockout mice. Here, late-phase long-term potentiation was normal, suggesting either that absence of fragile X mental retardation protein has no influence on long-term potentiation or that any influence is too subtle to be detected by this technique. Alternatively, the hippocampus may not be the primary site affected by the absence of this protein. Accordingly, we examined spatial learning in the knockout mice using the hippocampus-dependent Morris water maze. Contrary to earlier reports, near-normal performance was observed. Since the knockout line used in this study has been back-crossed to C57BL/6 for more than 15 generations, whereas the line used in the earlier studies contained a substantial strain 129 contribution, we examined F1 siblings of knockout and 129 crosses. Here, significant but subtle increased swim latencies in reversal trials were observed, in agreement with the previous studies. These data suggest strain differences between C57BL/6 and 129 that influence the Fmrl knockout phenotype. In order to investigate a paradigm less dependent on hippocampal function, the knockout mice were examined using the conditional fear paradigm. Here, the knockout animals displayed significantly less freezing behavior than their wild-type littermates following both contextual and conditional fear stimuli. These data suggest that amygdala disturbances may also be involved in fragile X syndrome.
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20 MeSH Terms
Neuropsychologic effects of stroke in children with sickle cell anemia.
Craft S, Schatz J, Glauser TA, Lee B, DeBaun MR
(1993) J Pediatr 123: 712-7
MeSH Terms: Adolescent, Anemia, Sickle Cell, Attention, Cerebrovascular Disorders, Child, Female, Humans, Male, Memory, Mental Processes, Neuropsychology, Spatial Behavior
Show Abstract · Added November 27, 2013
We examined the nature and extent of neuropsychologic impairment in children with sickle cell anemia (SCA) with or without stroke. Twenty-nine children with SCA received cranial magnetic resonance imaging. Strokes were classified into three groups: diffuse cortical stroke (n = 11), anterior stroke (n = 6), or none (n = 12). Children with SCA and 20 age-matched sibling control subjects then received a neurologic examination and a neuropsychologic battery of tests that included motor, verbal, spatial, attentional, and memory measures. Tests of spatial function showed that children with diffuse cortical strokes were impaired, whereas children with anterior lesions had intrusions of irrelevant material during list recall. There were no significant differences between children with stroke and sibling control subjects on motor, verbal, or memory measures. Six children had evidence of stroke on magnetic resonance imaging without any history of a damaging neurologic event. These children had impaired neuropsychologic performance relative to that of sibling control subjects in a pattern similar to that of children with overt stroke. Children with SCA without stroke did not differ from sibling control subjects on any measure. Our results indicate that overt and silent strokes result in lesion-specific neuropsychologic deficits in children with SCA.
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12 MeSH Terms