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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 27

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Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells.
Shiou SR, Singh AB, Moorthy K, Datta PK, Washington MK, Beauchamp RD, Dhawan P
(2007) Cancer Res 67: 1571-9
MeSH Terms: Animals, Cell Line, Tumor, Claudin-1, Colorectal Neoplasms, HCT116 Cells, HT29 Cells, Humans, Membrane Proteins, Neoplasm Invasiveness, RNA, Messenger, Rats, Signal Transduction, Smad4 Protein, TCF Transcription Factors, Transcription, Genetic, Transfection, Transforming Growth Factor beta, beta Catenin
Added June 14, 2013
1 Communities
4 Members
0 Resources
18 MeSH Terms
Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta.
Shiou SR, Datta PK, Dhawan P, Law BK, Yingling JM, Dixon DA, Beauchamp RD
(2006) J Biol Chem 281: 33971-81
MeSH Terms: Autocrine Communication, Blotting, Northern, Breast Neoplasms, Cell Membrane, Cell Proliferation, Collagen, Drug Combinations, Female, Genes, Dominant, Humans, Immunoblotting, Laminin, Matrix Metalloproteinase 9, Neoplasm Invasiveness, Paracrine Communication, Plasminogen Activator Inhibitor 1, Proteoglycans, RNA Stability, Receptors, Transforming Growth Factor beta, Smad4 Protein, Transforming Growth Factor beta, Tumor Cells, Cultured, Urokinase-Type Plasminogen Activator
Added June 14, 2013
1 Communities
2 Members
0 Resources
23 MeSH Terms
The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner.
Shi G, Boyle SC, Sparrow DB, Dunwoodie SL, Shioda T, de Caestecker MP
(2006) J Biol Chem 281: 27426-35
MeSH Terms: Apoptosis Regulatory Proteins, Cell Cycle, Cell Line, Tumor, Electrophoresis, Gel, Two-Dimensional, Gene Expression Regulation, Humans, Mutagenesis, Nuclear Proteins, Phosphorylation, Smad4 Protein, Subcellular Fractions, Trans-Activators, Transcription Factors, Transcriptional Activation, Trypsin, p300-CBP Transcription Factors
Added January 5, 2011
2 Communities
1 Members
0 Resources
16 MeSH Terms
Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells.
Grau AM, Datta PK, Zi J, Halder SK, Beauchamp RD
(2006) Cell Signal 18: 1041-50
MeSH Terms: Active Transport, Cell Nucleus, Activin Receptors, Type I, Animals, Cell Line, Tumor, Cell Nucleus, Colonic Neoplasms, DNA, Enzyme Activation, Epithelial Cells, Humans, I-kappa B Kinase, NF-kappa B, Phosphorylation, Protein Binding, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type I, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad4 Protein, Smad7 Protein, Transcriptional Activation, Transforming Growth Factor beta, Transforming Growth Factor beta1
Added May 3, 2013
0 Communities
1 Members
0 Resources
23 MeSH Terms
Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.
Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MP
(2005) J Am Soc Nephrol 16: 1632-44
MeSH Terms: Animals, Cell Differentiation, Cell Survival, Cytoskeletal Proteins, DNA-Binding Proteins, Epithelium, Intercellular Signaling Peptides and Proteins, Kidney, Nuclear Proteins, Organogenesis, Rats, Signal Transduction, Smad4 Protein, Trans-Activators, Transcription, Genetic, Transforming Growth Factor beta, Wnt Proteins, beta Catenin
Added January 5, 2011
2 Communities
1 Members
0 Resources
18 MeSH Terms
TGF-beta1 induction of the adenine nucleotide translocator 1 in astrocytes occurs through Smads and Sp1 transcription factors.
Law AK, Gupta D, Levy S, Wallace DC, McKeon RJ, Buck CR
(2004) BMC Neurosci 5: 1
MeSH Terms: Adenine Nucleotide Translocator 1, Animals, Astrocytes, Binding Sites, Cells, Cultured, Cerebral Cortex, Collodion, DNA-Binding Proteins, Electrophoretic Mobility Shift Assay, Gene Expression Regulation, Implants, Experimental, Mice, Mutagenesis, Site-Directed, Promoter Regions, Genetic, Response Elements, Sequence Deletion, Signal Transduction, Smad2 Protein, Smad3 Protein, Smad4 Protein, Sp1 Transcription Factor, Trans-Activators, Transforming Growth Factor beta, Transforming Growth Factor beta1
Added February 28, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation.
Berger DH, Feng XH, Yao J, Saha D, Beauchamp RD, Lin X
(2002) Surgery 132: 310-6
MeSH Terms: Animals, Cell Division, Cells, Cultured, DNA-Binding Proteins, Down-Regulation, Drug Resistance, Gene Expression, Intestinal Mucosa, Proto-Oncogene Proteins c-myc, Rats, Signal Transduction, Smad2 Protein, Smad4 Protein, Smad6 Protein, Trans-Activators, Transforming Growth Factor beta, Transforming Growth Factor beta1
Added May 3, 2013
0 Communities
1 Members
0 Resources
17 MeSH Terms
The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis.
Lee DK, Park SH, Yi Y, Choi SG, Lee C, Parks WT, Cho H, de Caestecker MP, Shaul Y, Roberts AB, Kim SJ
(2001) Genes Dev 15: 455-66
MeSH Terms: 3T3 Cells, Animals, Cell Nucleus, DNA-Binding Proteins, Hepatitis B virus, Liver Cirrhosis, Mice, Oncogene Proteins, Viral, Protein Binding, Signal Transduction, Smad4 Protein, Trans-Activators, Transcriptional Activation, Transforming Growth Factor beta
Added January 5, 2011
2 Communities
1 Members
0 Resources
14 MeSH Terms
The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.
Chacko BM, Qin B, Correia JJ, Lam SS, de Caestecker MP, Lin K
(2001) Nat Struct Biol 8: 248-53
MeSH Terms: Animals, Binding Sites, COS Cells, Chromatography, Gel, Conserved Sequence, Crystallography, X-Ray, DNA-Binding Proteins, Enzyme Activation, Gene Expression Regulation, Humans, Models, Biological, Models, Molecular, Peptide Fragments, Phosphorylation, Protein Binding, Protein Structure, Quaternary, Protein Structure, Tertiary, Protein Subunits, Signal Transduction, Smad3 Protein, Smad4 Protein, Static Electricity, Sulfates, Trans-Activators, Transfection, Transforming Growth Factor beta, Tumor Cells, Cultured
Added January 5, 2011
2 Communities
1 Members
0 Resources
27 MeSH Terms
Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta -induced physical and functional interactions between smads and Sp1.
Datta PK, Blake MC, Moses HL
(2000) J Biol Chem 275: 40014-9
MeSH Terms: Animals, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Humans, Plasminogen Activator Inhibitor 1, Smad3 Protein, Smad4 Protein, Sp1 Transcription Factor, Trans-Activators, Transforming Growth Factor beta
Added February 17, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms