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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 40

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5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.
Hutcheson JD, Ryzhova LM, Setola V, Merryman WD
(2012) J Mol Cell Cardiol 53: 707-14
MeSH Terms: Actins, Animals, Aortic Diseases, Aortic Valve, Calcinosis, Cell Differentiation, Cells, Cultured, Gene Expression, Indoles, Microfilament Proteins, Muscle Proteins, Myofibroblasts, Phosphorylation, Plasminogen Activator Inhibitor 1, Promoter Regions, Genetic, Protein Processing, Post-Translational, Protein Transport, Pyridines, Receptor, Serotonin, 5-HT2B, Serotonin 5-HT2 Receptor Antagonists, Signal Transduction, Smad3 Protein, Sus scrofa, Transcriptional Activation, Transforming Growth Factor beta1, Urea, p38 Mitogen-Activated Protein Kinases, src-Family Kinases
Added February 12, 2015
0 Communities
1 Members
0 Resources
28 MeSH Terms
PI3-kinase and TGF-β in glomerular nephropathy: which comes first?
Pozzi A
(2012) Kidney Int 82: 507-9
MeSH Terms: Animals, Class I Phosphatidylinositol 3-Kinases, Doxorubicin, Glomerulosclerosis, Focal Segmental, Kidney, Male, Proteinuria, Signal Transduction, Smad3 Protein
Added February 24, 2014
0 Communities
1 Members
1 Resources
9 MeSH Terms
Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature.
Nam KT, O'Neal R, Lee YS, Lee YC, Coffey RJ, Goldenring JR
(2012) Lab Invest 92: 883-95
MeSH Terms: Animals, Biomarkers, Tumor, Cell Line, Tumor, Cell Proliferation, Disease Models, Animal, Esophagogastric Junction, Female, Gastric Fundus, Gastric Mucosa, Gene Knockdown Techniques, Humans, Male, Mice, Mice, Inbred Strains, Mice, Knockout, Phosphorylation, Protein-Serine-Threonine Kinases, STAT3 Transcription Factor, Smad3 Protein, Stomach Neoplasms, Trefoil Factor-2
Added October 7, 2013
4 Communities
3 Members
0 Resources
21 MeSH Terms
Smoking attenuates transforming growth factor-β-mediated tumor suppression function through downregulation of Smad3 in lung cancer.
Samanta D, Gonzalez AL, Nagathihalli N, Ye F, Carbone DP, Datta PK
(2012) Cancer Prev Res (Phila) 5: 453-63
MeSH Terms: Acetylation, Adenocarcinoma, Animals, Apoptosis, Blotting, Western, Bronchi, Carcinoma, Squamous Cell, Cell Proliferation, Cells, Cultured, Down-Regulation, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Histones, Humans, Immunoenzyme Techniques, Immunoprecipitation, Lung Neoplasms, Mice, Mice, Nude, Phosphorylation, Protein Binding, RNA, Messenger, Real-Time Polymerase Chain Reaction, Signal Transduction, Smad3 Protein, Small Cell Lung Carcinoma, Smoking, Survival Rate, Tissue Array Analysis, Transcription, Genetic, Transforming Growth Factor beta
Added June 14, 2013
0 Communities
1 Members
0 Resources
31 MeSH Terms
EGFR signaling promotes TGFβ-dependent renal fibrosis.
Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC
(2012) J Am Soc Nephrol 23: 215-24
MeSH Terms: Angiotensin II, Animals, ErbB Receptors, Extracellular Signal-Regulated MAP Kinases, Fibrosis, Kidney, LLC-PK1 Cells, Male, Mice, Mice, Inbred BALB C, Phosphorylation, Reactive Oxygen Species, Signal Transduction, Smad2 Protein, Smad3 Protein, Swine, Transforming Growth Factor beta
Added August 19, 2013
1 Communities
1 Members
0 Resources
17 MeSH Terms
The TGF-β route to renal fibrosis is not linear: the miR-21 viaduct.
Eddy AA
(2011) J Am Soc Nephrol 22: 1573-5
MeSH Terms: Animals, MicroRNAs, Nephrosclerosis, Smad3 Protein, Transforming Growth Factor beta
Added February 3, 2012
1 Communities
1 Members
0 Resources
5 MeSH Terms
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer Ad, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszewski M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT, Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ
(2011) Am J Hum Genet 88: 6-18
MeSH Terms: Adult, African Americans, Asian Continental Ancestry Group, Body Height, Cardiovascular System, European Continental Ancestry Group, Female, Gene Frequency, Genetic Heterogeneity, Genetic Loci, Genome-Wide Association Study, Hispanic Americans, Humans, Interleukin-11, Male, Polymorphism, Single Nucleotide, Smad3 Protein
Added May 28, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.
Nam KT, Lee HJ, Smith JJ, Lapierre LA, Kamath VP, Chen X, Aronow BJ, Yeatman TJ, Bhartur SG, Calhoun BC, Condie B, Manley NR, Beauchamp RD, Coffey RJ, Goldenring JR
(2010) J Clin Invest 120: 840-9
MeSH Terms: Adenocarcinoma, Animals, Cell Transformation, Neoplastic, Colorectal Neoplasms, Epithelial Cells, Female, Gene Expression Regulation, Neoplastic, Humans, Integrin beta1, Intestinal Polyps, Male, Mice, Mice, Knockout, Neoplasm Staging, Proteins, Smad3 Protein, Tumor Suppressor Proteins, rab GTP-Binding Proteins
Added October 7, 2013
3 Communities
4 Members
0 Resources
18 MeSH Terms
Smad7 induces hepatic metastasis in colorectal cancer.
Halder SK, Rachakonda G, Deane NG, Datta PK
(2008) Br J Cancer 99: 957-65
MeSH Terms: Adenocarcinoma, Animals, Biomarkers, Tumor, Blotting, Western, Cadherins, Cell Proliferation, Claudin-1, Claudin-4, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Humans, Liver Neoplasms, Membrane Proteins, Mice, Mice, Nude, Phosphorylation, Polymerase Chain Reaction, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad2 Protein, Smad3 Protein, Smad7 Protein, Transforming Growth Factor beta, Tumor Cells, Cultured
Added May 10, 2013
0 Communities
1 Members
0 Resources
26 MeSH Terms
Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.
Brown KA, Ham AJ, Clark CN, Meller N, Law BK, Chytil A, Cheng N, Pietenpol JA, Moses HL
(2008) J Cell Biochem 105: 596-611
MeSH Terms: Blotting, Far-Western, Cell Line, Guanine Nucleotide Exchange Factors, Humans, Protein Binding, Proteins, Smad2 Protein, Smad3 Protein, Tandem Mass Spectrometry, Transduction, Genetic, Transforming Growth Factor beta1
Added May 27, 2014
0 Communities
2 Members
0 Resources
11 MeSH Terms