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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 95

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Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.
Grohar PJ, Segars LE, Yeung C, Pommier Y, D'Incalci M, Mendoza A, Helman LJ
(2014) Clin Cancer Res 20: 1190-203
MeSH Terms: Animals, Antineoplastic Agents, Camptothecin, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA Damage, Dioxoles, Disease Models, Animal, Doxorubicin, Drug Resistance, Neoplasm, Drug Synergism, Exodeoxyribonucleases, Female, Gene Expression Regulation, Neoplastic, Gene Silencing, Humans, Irinotecan, Mice, Oncogene Proteins, Fusion, Phenotype, Proto-Oncogene Protein c-fli-1, RNA Interference, RNA, Small Interfering, RNA-Binding Protein EWS, RecQ Helicases, Sarcoma, Ewing, Tetrahydroisoquinolines, Trabectedin, Werner Syndrome Helicase, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice.
Yu F, Du F, Wang Y, Huang S, Miao R, Major AS, Murphy EA, Fu M, Fan D
(2013) PLoS One 8: e80089
MeSH Terms: Animals, Atherosclerosis, Bone Marrow, Bone Marrow Transplantation, Female, Hyperlipidemias, Inflammation, Mice, Mice, Knockout, Ribonucleases
Added February 11, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Genome engineering using the CRISPR-Cas9 system.
Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F
(2013) Nat Protoc 8: 2281-2308
MeSH Terms: Base Sequence, Cell Culture Techniques, Cell Line, Clustered Regularly Interspaced Short Palindromic Repeats, DNA End-Joining Repair, DNA Mutational Analysis, DNA Repair, Deoxyribonucleases, Genetic Engineering, Genome, Genotyping Techniques, HEK293 Cells, Humans, Molecular Sequence Data, Mutagenesis, Transfection
Added February 10, 2015
0 Communities
0 Members
1 Resources
16 MeSH Terms
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.
Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR
(2013) PLoS Pathog 9: e1003565
MeSH Terms: Animals, Antiviral Agents, Apoptosis, Astrocytoma, Brain Neoplasms, Cell Proliferation, Coronavirus, Coronavirus Infections, Exoribonucleases, Genome, Viral, Humans, Mice, Mutagenesis, Mutagens, Mutation, RNA, Messenger, RNA, Viral, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Tumor Cells, Cultured, Viral Proteins, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system.
Jao LE, Wente SR, Chen W
(2013) Proc Natl Acad Sci U S A 110: 13904-9
MeSH Terms: Animals, Breeding, Deoxyribonucleases, Gene Knockout Techniques, Genetic Engineering, Genome, Inverted Repeat Sequences, Mutagenesis, Site-Directed, Phenotype, Zebrafish
Added March 7, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms
Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.
Zhang R, Jha BK, Ogden KM, Dong B, Zhao L, Elliott R, Patton JT, Silverman RH, Weiss SR
(2013) Proc Natl Acad Sci U S A 110: 13114-9
MeSH Terms: 2',5'-Oligoadenylate Synthetase, Adenine Nucleotides, Amino Acid Sequence, Animals, Binding Sites, Capsid Proteins, Cell Line, Cells, Cultured, Endoribonucleases, Host-Pathogen Interactions, Humans, Immunity, Innate, Immunoblotting, Macrophages, Mice, Mice, Knockout, Molecular Sequence Data, Murine hepatitis virus, Mutation, Oligoribonucleotides, Phosphoric Diester Hydrolases, RNA Virus Infections, RNA Viruses, Rotavirus, Sequence Homology, Amino Acid, Viral Nonstructural Proteins
Added April 3, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Identification and characterization of SMARCAL1 protein complexes.
B├ętous R, Glick GG, Zhao R, Cortez D
(2013) PLoS One 8: e63149
MeSH Terms: Cell Line, Tumor, DNA, DNA Breaks, Double-Stranded, DNA Helicases, DNA Repair, DNA Replication, DNA-Binding Proteins, Endonucleases, Exodeoxyribonucleases, HEK293 Cells, HeLa Cells, Humans, Immunoblotting, Immunoprecipitation, Mass Spectrometry, Nucleic Acid Conformation, Protein Binding, Proteomics, RecQ Helicases, Replication Protein A, S Phase, Werner Syndrome Helicase
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.
Graham RL, Becker MM, Eckerle LD, Bolles M, Denison MR, Baric RS
(2012) Nat Med 18: 1820-6
MeSH Terms: Age Factors, Animals, Base Sequence, DNA Primers, Drug Design, Exoribonucleases, Female, Immunocompromised Host, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Plasmids, Real-Time Polymerase Chain Reaction, SARS Virus, Sequence Analysis, DNA, Severe Acute Respiratory Syndrome, Statistics, Nonparametric, Viral Vaccines, Virus Replication
Added February 19, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Functional PstI/RsaI polymorphism in CYP2E1 is associated with the development, progression and poor outcome of gastric cancer.
Feng J, Pan X, Yu J, Chen Z, Xu H, El-Rifai W, Zhang G, Xu Z
(2012) PLoS One 7: e44478
MeSH Terms: Aged, Case-Control Studies, Cytochrome P-450 CYP2E1, Deoxyribonucleases, Type II Site-Specific, Disease Progression, Female, Gene Expression Regulation, Neoplastic, Genotype, Homozygote, Humans, Male, Middle Aged, Models, Genetic, Odds Ratio, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Prognosis, Regression Analysis, Stomach Neoplasms, Treatment Outcome
Added September 3, 2013
0 Communities
2 Members
0 Resources
20 MeSH Terms
Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Pallan PS, Allerson CR, Berdeja A, Seth PP, Swayze EE, Prakash TP, Egli M
(2012) Chem Commun (Camb) 48: 8195-7
MeSH Terms: DNA, Deoxyribonucleases, Models, Molecular, Nucleosides, Oligoribonucleotides
Added May 27, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms