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Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs.
Zaynagetdinov R, Sherrill TP, Gleaves LA, Hunt P, Han W, McLoed AG, Saxon JA, Tanjore H, Gulleman PM, Young LR, Blackwell TS
(2016) Oncotarget 7: 5470-82
MeSH Terms: Animals, Blotting, Western, CD8-Positive T-Lymphocytes, Cells, Cultured, Epithelium, Female, Flow Cytometry, Humans, I-kappa B Kinase, Immunosuppressive Agents, Inflammation, Interleukin-10, Lung, Lung Neoplasms, Macrophages, Alveolar, Male, Mice, Mice, Transgenic, NF-kappa B, Pulmonary Disease, Chronic Obstructive, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, T-Lymphocytes, Regulatory, Transforming Growth Factor beta
Added February 22, 2016
1 Communities
1 Members
0 Resources
26 MeSH Terms
Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection.
Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE
(2015) PLoS Pathog 11: e1005341
MeSH Terms: Animals, Cell Hypoxia, Cell Line, DNA Transposable Elements, Disease Models, Animal, Female, Gene Expression Regulation, Bacterial, Genes, Viral, Host-Pathogen Interactions, Humans, Mice, Mice, Inbred C57BL, Oligonucleotide Array Sequence Analysis, Osteomyelitis, Quorum Sensing, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcal Infections, Staphylococcus aureus, Virulence, Virulence Factors
Added February 8, 2016
0 Communities
2 Members
0 Resources
20 MeSH Terms
NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.
Bretz CA, Savage SR, Capozzi ME, Suarez S, Penn JS
(2015) Sci Rep 5: 14963
MeSH Terms: Animals, Cell Adhesion, Cells, Cultured, Chemokine CCL2, Chemokine CX3CL1, Chemokine CXCL10, Chemokine CXCL11, Disease Models, Animal, E-Selectin, Endothelial Cells, Enzyme-Linked Immunosorbent Assay, Gene Expression, Humans, Intercellular Adhesion Molecule-1, Leukostasis, Male, Mice, Inbred C57BL, NFATC Transcription Factors, Protein Isoforms, RNA Interference, Retinal Diseases, Retinal Vessels, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, Vascular Cell Adhesion Molecule-1
Added April 10, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
Lack of IL7Rα expression in T cells is a hallmark of T-cell immunodeficiency in Schimke immuno-osseous dysplasia (SIOD).
Sanyal M, Morimoto M, Baradaran-Heravi A, Choi K, Kambham N, Jensen K, Dutt S, Dionis-Petersen KY, Liu LX, Felix K, Mayfield C, Dekel B, Bokenkamp A, Fryssira H, Guillen-Navarro E, Lama G, Brugnara M, Lücke T, Olney AH, Hunley TE, Polat AI, Yis U, Bogdanovic R, Mitrovic K, Berry S, Najera L, Najafian B, Gentile M, Nur Semerci C, Tsimaratos M, Lewis DB, Boerkoel CF
(2015) Clin Immunol 161: 355-65
MeSH Terms: Adolescent, Adult, Arteriosclerosis, Cells, Cultured, Child, Child, Preschool, DNA Helicases, DNA Methylation, Flow Cytometry, Gene Expression, Humans, Immunohistochemistry, Immunologic Deficiency Syndromes, Interleukin-17, Leukocytes, Mononuclear, Mutation, Nephrotic Syndrome, Osteochondrodysplasias, Primary Immunodeficiency Diseases, Promoter Regions, Genetic, Pulmonary Embolism, Receptors, Interleukin-7, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, T-Lymphocytes, Young Adult
Added July 5, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation.
Li M, Page-McCaw P, Chen W
(2016) Diabetes 65: 96-109
MeSH Terms: Animals, Animals, Genetically Modified, Cell Differentiation, Cell Line, Tumor, Endoplasmic Reticulum Stress, Fibroblast Growth Factor 1, Flow Cytometry, Humans, Insulin-Secreting Cells, Overnutrition, RNA, Messenger, Rats, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Zebrafish, Zebrafish Proteins
Added February 15, 2016
0 Communities
1 Members
0 Resources
16 MeSH Terms
Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis.
Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK
(2015) Circ Res 117: 804-16
MeSH Terms: Angiopoietin-1, Animals, Arterioles, Blood Vessels, Blotting, Western, Cell Line, Cell Proliferation, Cells, Cultured, Endothelial Cells, Fibrosis, Gene Expression, Humans, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Confocal, Muscle, Smooth, Vascular, Myocardium, Myocytes, Cardiac, Myocytes, Smooth Muscle, Myofibroblasts, NF-kappa B, Proto-Oncogene Proteins, Reverse Transcriptase Polymerase Chain Reaction, Vascular Endothelial Growth Factor Receptor-2, Wnt Proteins
Added February 23, 2016
2 Communities
1 Members
0 Resources
25 MeSH Terms
Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes.
Love JD, Suzuki T, Robinson DB, Harris CM, Johnson JE, Mohler PJ, Jerome WG, Swift LL
(2015) PLoS One 10: e0135598
MeSH Terms: 3T3-L1 Cells, Adipocytes, Animals, Carrier Proteins, Cell Differentiation, Cytosol, Electrophoresis, Polyacrylamide Gel, Immunohistochemistry, Lipid Droplets, Mice, Microscopy, Fluorescence, Reverse Transcriptase Polymerase Chain Reaction
Added September 30, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Respiratory Viral Detection in Children and Adults: Comparing Asymptomatic Controls and Patients With Community-Acquired Pneumonia.
Self WH, Williams DJ, Zhu Y, Ampofo K, Pavia AT, Chappell JD, Hymas WC, Stockmann C, Bramley AM, Schneider E, Erdman D, Finelli L, Jain S, Edwards KM, Grijalva CG
(2016) J Infect Dis 213: 584-91
MeSH Terms: Adolescent, Adult, Age Factors, Aged, Asymptomatic Diseases, Child, Child, Preschool, Community-Acquired Infections, Female, Humans, Infant, Male, Middle Aged, Pneumonia, Viral, Prospective Studies, Real-Time Polymerase Chain Reaction, Respiratory Syncytial Viruses, Respiratory System, Reverse Transcriptase Polymerase Chain Reaction, Viruses
Added July 27, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
An Iron-Regulated Autolysin Remodels the Cell Wall To Facilitate Heme Acquisition in Staphylococcus lugdunensis.
Farrand AJ, Haley KP, Lareau NM, Heilbronner S, McLean JA, Foster T, Skaar EP
(2015) Infect Immun 83: 3578-89
MeSH Terms: Bacterial Proteins, Cell Wall, Fluorescent Antibody Technique, Immunoblotting, Iron, Mass Spectrometry, N-Acetylmuramoyl-L-alanine Amidase, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcal Infections, Staphylococcus lugdunensis
Added February 8, 2016
0 Communities
1 Members
0 Resources
11 MeSH Terms
Respiratory Viral Detections During Symptomatic and Asymptomatic Periods in Young Andean Children.
Howard LM, Johnson M, Williams JV, Zhu Y, Gil AI, Edwards KM, Griffin MR, Lanata CF, Grijalva CG, RESPIRA-PERU Group
(2015) Pediatr Infect Dis J 34: 1074-80
MeSH Terms: Child, Humans, Peru, Random Allocation, Respiratory Tract Infections, Reverse Transcriptase Polymerase Chain Reaction, Viral Load, Viruses
Added July 27, 2018
0 Communities
1 Members
0 Resources
MeSH Terms