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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 104

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Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M PAM VU6004256.
Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK
(2016) ACS Chem Neurosci 7: 1706-1716
MeSH Terms: Action Potentials, Animals, Cholinergic Agents, Cognition Disorders, Conditioning, Psychological, Disease Models, Animal, Drug Evaluation, Preclinical, Fear, Gene Knockdown Techniques, Heterocyclic Compounds, 4 or More Rings, Long-Term Synaptic Depression, Male, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Nerve Tissue Proteins, Nootropic Agents, Prefrontal Cortex, Pyramidal Cells, Receptors, N-Methyl-D-Aspartate, Recognition, Psychology, Tissue Culture Techniques
Added April 6, 2017
0 Communities
3 Members
0 Resources
23 MeSH Terms
Changes in the Adult GluN2B Associated Proteome following Adolescent Intermittent Ethanol Exposure.
Swartzwelder HS, Risher ML, Miller KM, Colbran RJ, Winder DG, Wills TA
(2016) PLoS One 11: e0155951
MeSH Terms: Adolescent, Animals, Disease Models, Animal, Ethanol, Female, Hippocampus, Humans, Male, Protein Interaction Maps, Proteome, Proteomics, Rats, Sprague-Dawley, Receptors, N-Methyl-D-Aspartate, Signal Transduction, Underage Drinking
Added April 26, 2017
0 Communities
2 Members
0 Resources
15 MeSH Terms
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.
Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H
(2016) Nature 534: 63-8
MeSH Terms: Animals, Apoproteins, Cryoelectron Microscopy, Crystallography, X-Ray, Electrophysiology, Ion Channel Gating, Ligands, Models, Molecular, Piperidines, Protein Conformation, Protein Multimerization, Protein Subunits, Rats, Receptors, N-Methyl-D-Aspartate
Added April 3, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Novel PAMs Targeting NMDAR GluN2A Subunit.
Xiang Z, Conn PJ
(2016) Neuron 89: 884-6
MeSH Terms: Animals, Humans, Models, Molecular, Nerve Net, Neurons, Receptors, N-Methyl-D-Aspartate
Added April 6, 2017
0 Communities
1 Members
0 Resources
6 MeSH Terms
Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, Haines JL, Thornton-Wells TA, Alzheimer's Disease Genetics Consortium
(2016) Neurobiol Aging 38: 141-150
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, Alzheimer Disease, Cadherin Related Proteins, Cadherins, Calcium Channels, L-Type, Datasets as Topic, Disease Progression, Epistasis, Genetic, Female, Genetic Association Studies, Humans, Male, Models, Genetic, Phosphatidylethanolamine Binding Protein, Polymorphism, Single Nucleotide, Receptors, Adrenergic, alpha-1, Receptors, N-Methyl-D-Aspartate, Risk, Ryanodine Receptor Calcium Release Channel, Saposins, Sirtuin 1
Added April 10, 2018
0 Communities
1 Members
0 Resources
21 MeSH Terms
An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia.
Balu DT, Li Y, Takagi S, Presti KT, Ramikie TS, Rook JM, Jones CK, Lindsley CW, Conn PJ, Bolshakov VY, Coyle JT
(2016) Neuropsychopharmacology 41: 2052-61
MeSH Terms: Allosteric Regulation, Animals, Disease Models, Animal, Hippocampus, Male, Mice, Inbred C57BL, Mice, Knockout, Neuronal Plasticity, Oxazoles, Proto-Oncogene Proteins c-akt, Pyridines, Racemases and Epimerases, Receptor, Metabotropic Glutamate 5, Receptors, N-Methyl-D-Aspartate, Schizophrenia, Signal Transduction
Added February 18, 2016
0 Communities
3 Members
0 Resources
16 MeSH Terms
Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates group I mGlu receptor-dependent long-term depression.
Wills TA, Baucum AJ, Holleran KM, Chen Y, Pasek JG, Delpire E, Tabb DL, Colbran RJ, Winder DG
(2017) Addict Biol 22: 275-290
MeSH Terms: Animals, Central Nervous System Depressants, Cytoskeletal Proteins, Ethanol, Hippocampus, Homer Scaffolding Proteins, Long-Term Synaptic Depression, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins, Proteome, Receptors, Metabotropic Glutamate, Receptors, N-Methyl-D-Aspartate, Signal Transduction
Added February 15, 2016
0 Communities
3 Members
0 Resources
16 MeSH Terms
Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia.
Karol SE, Yang W, Van Driest SL, Chang TY, Kaste S, Bowton E, Basford M, Bastarache L, Roden DM, Denny JC, Larsen E, Winick N, Carroll WL, Cheng C, Pei D, Fernandez CA, Liu C, Smith C, Loh ML, Raetz EA, Hunger SP, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Mattano LA, Relling MV
(2015) Blood 126: 1770-6
MeSH Terms: Biomarkers, Child, Cohort Studies, Dexamethasone, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Glucocorticoids, Humans, Male, Meta-Analysis as Topic, Neoplasm Staging, Osteonecrosis, Polymorphism, Single Nucleotide, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Receptors, N-Methyl-D-Aspartate, Risk Factors
Added April 11, 2017
0 Communities
3 Members
0 Resources
19 MeSH Terms
Emerging structural insights into the function of ionotropic glutamate receptors.
Karakas E, Regan MC, Furukawa H
(2015) Trends Biochem Sci 40: 328-37
MeSH Terms: Brain, Humans, Ligand-Gated Ion Channels, Protein Conformation, Receptors, AMPA, Receptors, Ionotropic Glutamate, Receptors, Kainic Acid, Receptors, N-Methyl-D-Aspartate, Structure-Activity Relationship, Synaptic Transmission
Added April 3, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ
(2015) Neuron 86: 1029-1040
MeSH Terms: Allosteric Regulation, Animals, Antipsychotic Agents, Cognition, Glutamic Acid, HEK293 Cells, Hippocampus, Humans, Male, Rats, Sprague-Dawley, Receptor, Metabotropic Glutamate 5, Receptors, N-Methyl-D-Aspartate, Signal Transduction
Added February 18, 2016
0 Communities
5 Members
0 Resources
13 MeSH Terms