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Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity.
Raman D, Milatovic SZ, Milatovic D, Splittgerber R, Fan GH, Richmond A
(2011) Toxicol Appl Pharmacol 256: 300-13
MeSH Terms: Amyloid beta-Peptides, Animals, Apoptosis, Brain, Chemokine CXCL12, Chemokine CXCL2, Chemokines, F2-Isoprostanes, Mice, Mice, Inbred C57BL, Neurons, Neuroprotective Agents, Neurotoxicity Syndromes, Real-Time Polymerase Chain Reaction, Receptors, Interleukin-8B
Added May 30, 2013
2 Communities
2 Members
0 Resources
15 MeSH Terms
Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitment.
Das ST, Rajagopalan L, Guerrero-Plata A, Sai J, Richmond A, Garofalo RP, Rajarathnam K
(2010) PLoS One 5: e11754
MeSH Terms: Animals, Endothelial Cells, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Glycosaminoglycans, HL-60 Cells, Humans, Interleukin-8, Mice, Mice, Inbred BALB C, Microfluidic Analytical Techniques, Models, Biological, Neutrophil Infiltration, Neutrophils, Protein Binding, Protein Multimerization, Receptors, Interleukin-8B
Added May 31, 2013
2 Communities
1 Members
0 Resources
18 MeSH Terms
LIM and SH3 protein-1 modulates CXCR2-mediated cell migration.
Raman D, Sai J, Neel NF, Chew CS, Richmond A
(2010) PLoS One 5: e10050
MeSH Terms: Adaptor Proteins, Signal Transducing, Binding Sites, Cell Line, Chemotaxis, Cytoskeletal Proteins, Focal Adhesions, HL-60 Cells, Humans, Immunoprecipitation, LIM Domain Proteins, Protein Binding, Protein Interaction Mapping, Receptors, Interleukin-8B
Added December 5, 2013
3 Communities
2 Members
0 Resources
13 MeSH Terms
Characterization of chemokine receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 "chemosynapse".
Raman D, Neel NF, Sai J, Mernaugh RL, Ham AJ, Richmond AJ
(2009) Methods Enzymol 460: 315-30
MeSH Terms: HL-60 Cells, Humans, Immunohistochemistry, Immunoprecipitation, Microscopy, Confocal, Protein Binding, Proteins, Proteomics, Receptors, Interleukin-8B
Added May 30, 2013
2 Communities
3 Members
0 Resources
9 MeSH Terms
VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis.
Neel NF, Barzik M, Raman D, Sobolik-Delmaire T, Sai J, Ham AJ, Mernaugh RL, Gertler FB, Richmond A
(2009) J Cell Sci 122: 1882-94
MeSH Terms: Actins, Animals, Cell Adhesion Molecules, Cell Membrane, Cell Polarity, Chemotaxis, Cyclic AMP-Dependent Protein Kinases, HL-60 Cells, Humans, Interleukin-8, Leukocytes, Microfilament Proteins, Phosphoproteins, Phosphorylation, Protein Kinase C, Protein Structure, Tertiary, Receptors, Interleukin-8B, Recombinant Fusion Proteins, Serine, Signal Transduction
Added December 5, 2013
3 Communities
3 Members
0 Resources
20 MeSH Terms
CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healing.
Zaja-Milatovic S, Richmond A
(2008) Histol Histopathol 23: 1399-407
MeSH Terms: Animals, Chemokines, CXC, Humans, Immunity, Innate, Macrophages, Neutrophil Infiltration, Neutrophils, Receptors, CXCR, Receptors, Interleukin-8B, Signal Transduction, Skin, Wound Healing
Added May 30, 2013
2 Communities
1 Members
0 Resources
12 MeSH Terms
The carboxyl-terminal PDZ ligand motif of chemokine receptor CXCR2 modulates post-endocytic sorting and cellular chemotaxis.
Baugher PJ, Richmond A
(2008) J Biol Chem 283: 30868-78
MeSH Terms: Amino Acid Motifs, Cell Line, Chemotaxis, Endocytosis, Endosomes, Humans, Lysosomes, PDZ Domains, Protein Transport, Receptors, Interleukin-8B, Ubiquitination, rab GTP-Binding Proteins, rab7 GTP-Binding Proteins
Added May 30, 2013
2 Communities
1 Members
0 Resources
13 MeSH Terms
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
(2008) J Biol Chem 283: 26538-47
MeSH Terms: Androstadienes, Animals, Cell Polarity, Chemotaxis, GTPase-Activating Proteins, Guanine Nucleotide Exchange Factors, HL-60 Cells, Humans, Interleukin-8, Mice, Mice, Knockout, Nerve Tissue Proteins, Neutrophils, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Proto-Oncogene Proteins c-hck, Pyrimidines, Receptors, Interleukin-8B, Signal Transduction, Wortmannin, rac GTP-Binding Proteins, src-Family Kinases
Added May 30, 2013
2 Communities
4 Members
0 Resources
22 MeSH Terms
Short tail with skin lesion phenotype occurs in transgenic mice with keratin-14 promoter-directed expression of mutant CXCR2.
Yu Y, Su Y, Opalenik SR, Sobolik-Delmaire T, Neel NF, Zaja-Milatovic S, Short ST, Sai J, Richmond A
(2008) J Leukoc Biol 84: 406-19
MeSH Terms: Amino Acid Sequence, Animals, Enhancer Elements, Genetic, Humans, Keratin-14, Mice, Mice, Mutant Strains, Mice, Transgenic, Molecular Sequence Data, Mutation, Promoter Regions, Genetic, Receptors, Interleukin-8B, Sequence Deletion, Skin, Tail
Added June 6, 2013
3 Communities
3 Members
0 Resources
15 MeSH Terms
Microfluidic switching system for analyzing chemotaxis responses of wortmannin-inhibited HL-60 cells.
Liu Y, Sai J, Richmond A, Wikswo JP
(2008) Biomed Microdevices 10: 499-507
MeSH Terms: Androstadienes, Cell Differentiation, Cell Movement, Cell Shape, Chemotaxis, Culture Media, Serum-Free, Dimethyl Sulfoxide, Enzyme Inhibitors, Equipment Design, HL-60 Cells, Humans, Microfluidics, Phosphoinositide-3 Kinase Inhibitors, Receptors, Interleukin-8B, Solutions, Solvents, Temperature, Time Factors, Transfection, Wortmannin
Added May 30, 2013
2 Communities
3 Members
0 Resources
20 MeSH Terms