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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 81

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Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells.
Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, Fogo AB, Hao CM, Harris RC, Zent R, Gewin L
(2015) Kidney Int 88: 503-14
MeSH Terms: Actins, Animals, Aristolochic Acids, Cells, Cultured, Collagen Type I, Disease Models, Animal, Extracellular Matrix, Fibrosis, Kidney, Kidney Diseases, Mice, Inbred C57BL, Mice, Knockout, Protein-Serine-Threonine Kinases, Receptor, Platelet-Derived Growth Factor beta, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Time Factors, Transforming Growth Factor beta, Ureteral Obstruction
Added August 3, 2015
1 Communities
3 Members
0 Resources
20 MeSH Terms
TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.
Shaw AK, Pickup MW, Chytil A, Aakre M, Owens P, Moses HL, Novitskiy SV
(2015) PLoS One 10: e0117908
MeSH Terms: Animals, Cell Line, Tumor, Cell Movement, Female, Fibroblasts, Mammary Neoplasms, Experimental, Mice, Myeloid Cells, Neoplasm Invasiveness, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Transforming Growth Factor beta
Added February 12, 2015
1 Communities
2 Members
0 Resources
14 MeSH Terms
Increased pSmad2 expression and cytoplasmic predominant presence of TGF-βRII in breast cancer tissue are associated with poor prognosis: results from the Shanghai Breast Cancer Study.
Qiu Q, Su Y, Zheng Y, Cai H, Wu S, Lu W, Zheng W, Shu XO, Cai Q
(2015) Breast Cancer Res Treat 149: 467-77
MeSH Terms: Adult, Aged, Breast Neoplasms, China, Cytoplasm, Female, Gene Expression, Humans, Immunohistochemistry, Middle Aged, Neoplasm Grading, Neoplasm Staging, Prognosis, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Risk Factors, Smad2 Protein, Tumor Burden
Added January 20, 2015
0 Communities
2 Members
0 Resources
19 MeSH Terms
Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma.
Andl T, Le Bras GF, Richards NF, Allison GL, Loomans HA, Washington MK, Revetta F, Lee RK, Taylor C, Moses HL, Andl CD
(2014) Carcinogenesis 35: 2602-10
MeSH Terms: Animals, Antigens, CD, Cadherins, Carcinogenesis, Carcinoma, Squamous Cell, Cell Proliferation, Cyclin D1, Epithelial Cells, Homeostasis, Humans, Mice, Mouth Neoplasms, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Tamoxifen
Added December 3, 2014
2 Communities
3 Members
0 Resources
17 MeSH Terms
Role of TGF-β signaling in generation of CD39+CD73+ myeloid cells in tumors.
Ryzhov SV, Pickup MW, Chytil A, Gorska AE, Zhang Q, Owens P, Feoktistov I, Moses HL, Novitskiy SV
(2014) J Immunol 193: 3155-64
MeSH Terms: 5'-Nucleotidase, Animals, Antigens, CD, Apyrase, Bone Marrow Cells, Carcinoma, Lewis Lung, Cell Differentiation, Cell Line, Tumor, Cell Movement, Female, Mammary Glands, Animal, Mammary Neoplasms, Animal, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Cells, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, T-Lymphocytes, Transforming Growth Factor beta, Tumor Microenvironment, Vascular Endothelial Growth Factor A
Added December 3, 2014
2 Communities
2 Members
0 Resources
24 MeSH Terms
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A
(2014) J Clin Invest 124: 3295-310
MeSH Terms: Animals, Collagen, Epithelial-Mesenchymal Transition, Fibrosis, Integrin alpha1, Integrin alpha1beta1, Kidney, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Phosphorylation, Protein Tyrosine Phosphatase, Non-Receptor Type 2, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Smad Proteins, Smad2 Protein, Smad3 Protein, Tyrosine, Ureteral Obstruction
Added October 27, 2014
2 Communities
4 Members
1 Resources
23 MeSH Terms
Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas.
Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL
(2013) Cancer Res 73: 5336-46
MeSH Terms: Animals, Carcinogenesis, Collagen, Enzyme Inhibitors, Female, Fibroblasts, Focal Adhesion Kinase 1, Humans, In Situ Hybridization, Keratin-14, Lung Neoplasms, Mammary Neoplasms, Experimental, Mice, Mice, Transgenic, Microscopy, Atomic Force, Myeloid Cells, Phosphorylation, Protein-Lysine 6-Oxidase, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Stromal Cells, Transforming Growth Factor beta
Added February 17, 2014
1 Communities
2 Members
0 Resources
24 MeSH Terms
Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals.
Miyabayashi K, Ijichi H, Mohri D, Tada M, Yamamoto K, Asaoka Y, Ikenoue T, Tateishi K, Nakai Y, Isayama H, Morishita Y, Omata M, Moses HL, Koike K
(2013) Cancer Res 73: 2221-34
MeSH Terms: Animals, Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Blotting, Western, Carcinoma, Pancreatic Ductal, Cell Proliferation, Deoxycytidine, Enzyme-Linked Immunosorbent Assay, Erlotinib Hydrochloride, Flow Cytometry, Immunoenzyme Techniques, Immunoprecipitation, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitogen-Activated Protein Kinases, Pancreatic Neoplasms, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins p21(ras), Quinazolines, RNA, Messenger, Real-Time Polymerase Chain Reaction, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Survival Rate, Tumor Cells, Cultured
Added March 7, 2014
1 Communities
1 Members
0 Resources
29 MeSH Terms
Deleting the TGF-β receptor attenuates acute proximal tubule injury.
Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R
(2012) J Am Soc Nephrol 23: 2001-11
MeSH Terms: Acute Kidney Injury, Animals, Apoptosis, Kidney Cortex, Kidney Tubules, Proximal, Male, Mercuric Chloride, Mice, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Smad Proteins, Transforming Growth Factor beta
Added February 24, 2014
1 Communities
4 Members
1 Resources
13 MeSH Terms
Lack of transforming growth factor-β signaling promotes collective cancer cell invasion through tumor-stromal crosstalk.
Matise LA, Palmer TD, Ashby WJ, Nashabi A, Chytil A, Aakre M, Pickup MW, Gorska AE, Zijlstra A, Moses HL
(2012) Breast Cancer Res 14: R98
MeSH Terms: Animals, Cadherins, Cell Communication, Cell Line, Tumor, Cell Movement, Epithelial-Mesenchymal Transition, Fibroblasts, Gene Expression Regulation, Neoplastic, Gene Knockout Techniques, Humans, Intercellular Junctions, Mice, Neoplasms, Phenotype, Protein Transport, Protein-Serine-Threonine Kinases, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta, Signal Transduction, Stromal Cells, Transforming Growth Factor beta, beta Catenin
Added February 17, 2014
1 Communities
2 Members
0 Resources
22 MeSH Terms