Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 11 to 20 of 22

Publication Record

Connections

Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartmentalized cyclic nucleotide actions.
Bilodeau ML, Hamm HE
(2007) J Pharmacol Exp Ther 322: 778-88
MeSH Terms: 1-Methyl-3-isobutylxanthine, Blood Platelets, Bucladesine, Calcium, Cell Adhesion Molecules, Colforsin, Cyclic AMP, Cyclic GMP, Dose-Response Relationship, Drug, Humans, Indazoles, Kinetics, Microfilament Proteins, Nucleotides, Cyclic, Oligopeptides, Peptide Fragments, Phosphoproteins, Phosphorylation, Platelet Activation, Platelet Aggregation, Platelet Aggregation Inhibitors, Receptor, PAR-1, Receptors, Thrombin, Signal Transduction, Thionucleotides, Thrombin
Added December 10, 2013
0 Communities
1 Members
0 Resources
26 MeSH Terms
PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis.
Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE
(2007) Mol Pharmacol 71: 1399-406
MeSH Terms: Blood Coagulation, Blood Platelets, Calcium, Enzyme Activation, GTP-Binding Protein alpha Subunits, Gi-Go, Humans, Phosphatidylinositol 3-Kinases, Platelet Activation, Platelet Glycoprotein GPIIb-IIIa Complex, Receptor, PAR-1, Receptors, Thrombin, Signal Transduction
Added December 10, 2013
1 Communities
2 Members
0 Resources
12 MeSH Terms
Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.
Zhang G, Kernan KA, Collins SJ, Cai X, López-Guisa JM, Degen JL, Shvil Y, Eddy AA
(2007) J Am Soc Nephrol 18: 846-59
MeSH Terms: Actins, Animals, Butadienes, Cadherins, Cell Movement, Collagen, Disease Models, Animal, Enzyme Inhibitors, Extracellular Signal-Regulated MAP Kinases, Female, Fibrinolysin, Fibrosis, Kidney, Kidney Diseases, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nitriles, Phosphorylation, Plasminogen Activator Inhibitor 1, Receptor, PAR-1, Signal Transduction, Transforming Growth Factor beta, Ureteral Obstruction
Added February 3, 2012
0 Communities
1 Members
0 Resources
25 MeSH Terms
Protease-activated receptors differentially regulate human platelet activation through a phosphatidic acid-dependent pathway.
Holinstat M, Voss B, Bilodeau ML, Hamm HE
(2007) Mol Pharmacol 71: 686-94
MeSH Terms: Cytoplasmic Granules, Dose-Response Relationship, Drug, Humans, Nadolol, Phosphatidate Phosphatase, Phosphatidic Acids, Phospholipase D, Platelet Activation, Platelet Aggregation, Platelet Glycoprotein GPIIb-IIIa Complex, Propranolol, Protein Kinase C, Receptor, PAR-1, Receptors, Thrombin, rap1 GTP-Binding Proteins
Added December 10, 2013
0 Communities
1 Members
0 Resources
15 MeSH Terms
PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.
Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE
(2006) J Biol Chem 281: 26665-74
MeSH Terms: Adenosine Diphosphate, Blood Platelets, Calcium, Calcium Signaling, Chelating Agents, Egtazic Acid, Fibrinogen, Humans, Platelet Activation, Platelet Aggregation, Platelet Aggregation Inhibitors, Platelet Glycoprotein GPIIb-IIIa Complex, Purinergic P2 Receptor Antagonists, Receptor, PAR-1, Receptors, Purinergic P2, Receptors, Purinergic P2Y12, Receptors, Thrombin, Thrombin
Added December 10, 2013
0 Communities
1 Members
0 Resources
18 MeSH Terms
MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells.
Ducharme NA, Hales CM, Lapierre LA, Ham AJ, Oztan A, Apodaca G, Goldenring JR
(2006) Mol Biol Cell 17: 3625-37
MeSH Terms: Adherens Junctions, Amino Acid Sequence, Animals, Calcium Signaling, Cell Polarity, Cells, Cultured, Dogs, Epithelial Cells, Gene Expression, Molecular Sequence Data, Mutation, Myosin Type V, Phosphorylation, Protein Binding, Protein Transport, Protein-Serine-Threonine Kinases, Rabbits, Receptor, PAR-1, rab GTP-Binding Proteins
Added October 7, 2013
1 Communities
1 Members
0 Resources
19 MeSH Terms
Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP.
Cleator JH, Zhu WQ, Vaughan DE, Hamm HE
(2006) Blood 107: 2736-44
MeSH Terms: Calcium Signaling, Cell Line, Cyclic AMP, Endothelium, Vascular, Exocytosis, Humans, Kinetics, P-Selectin, Peptide Hydrolases, Protein Transport, Receptor, PAR-1, Receptor, PAR-2, Receptors, Cell Surface, Signal Transduction, Thrombin, Umbilical Veins, von Willebrand Factor
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.
McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE
(2005) J Biol Chem 280: 25048-59
MeSH Terms: Actins, Adenosine Diphosphate, Amides, Calcium, Cells, Cultured, Chelating Agents, Dipeptides, Dose-Response Relationship, Drug, Egtazic Acid, Electric Impedance, Endothelium, Vascular, Enzyme Inhibitors, GTP-Binding Protein alpha Subunits, G12-G13, GTP-Binding Protein alpha Subunits, Gq-G11, GTP-Binding Proteins, Humans, Intracellular Signaling Peptides and Proteins, Kinetics, Ligands, Matrix Metalloproteinase Inhibitors, Microcirculation, Models, Biological, Models, Theoretical, Peptides, Pertussis Toxin, Protease Inhibitors, Protein Binding, Protein-Serine-Threonine Kinases, Pyridines, Receptor, PAR-1, Signal Transduction, Thrombin, Time Factors, rho-Associated Kinases
Added December 10, 2013
0 Communities
1 Members
0 Resources
34 MeSH Terms
Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells.
McLaughlin JN, Mazzoni MR, Cleator JH, Earls L, Perdigoto AL, Brooks JD, Muldowney JA, Vaughan DE, Hamm HE
(2005) J Biol Chem 280: 22172-80
MeSH Terms: Adenosine Diphosphate, Algorithms, Amides, Apoptosis, Cells, Cultured, Cluster Analysis, Culture Media, DNA Primers, DNA, Complementary, Dose-Response Relationship, Drug, Electric Impedance, Endothelium, Vascular, Enzyme-Linked Immunosorbent Assay, Extracellular Matrix, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Expression Regulation, Humans, Indoles, Maleimides, Microcirculation, Models, Biological, Nucleic Acid Hybridization, Oligonucleotide Array Sequence Analysis, Peptides, Pertussis Toxin, Promoter Regions, Genetic, Protein Binding, Pyridines, RNA, Receptor, PAR-1, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Thrombin, Thrombospondin 1, Time Factors, Umbilical Veins, Up-Regulation
Added December 10, 2013
0 Communities
1 Members
0 Resources
38 MeSH Terms
Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cells.
Tang H, Low B, Rutherford SA, Hao Q
(2005) Blood 105: 1977-85
MeSH Terms: Antigens, CD, Aorta, Down-Regulation, Endocytosis, Endoglin, Endothelium, Vascular, Humans, Protein-Serine-Threonine Kinases, Receptor, PAR-1, Receptor, Transforming Growth Factor-beta Type II, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Receptors, Transforming Growth Factor beta, Signal Transduction, Thrombin, Transforming Growth Factor beta, Umbilical Veins, Vascular Cell Adhesion Molecule-1
Added August 13, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms