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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 40

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Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2.
Rexer BN, Ghosh R, Narasanna A, Estrada MV, Chakrabarty A, Song Y, Engelman JA, Arteaga CL
(2013) Clin Cancer Res 19: 5390-401
MeSH Terms: Amino Acid Substitution, Animals, Antineoplastic Agents, Breast Neoplasms, Catalysis, Cell Line, Tumor, Cell Proliferation, Cell Survival, Codon, Disease Models, Animal, Drug Resistance, Neoplasm, ErbB Receptors, Female, Gene Amplification, Gene Expression, Humans, Ligands, Mice, Mutation, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Receptor, ErbB-2, Receptor, ErbB-3, Xenograft Model Antitumor Assays
Added September 3, 2013
0 Communities
3 Members
0 Resources
24 MeSH Terms
An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
Garner AP, Bialucha CU, Sprague ER, Garrett JT, Sheng Q, Li S, Sineshchekova O, Saxena P, Sutton CR, Chen D, Chen Y, Wang H, Liang J, Das R, Mosher R, Gu J, Huang A, Haubst N, Zehetmeier C, Haberl M, Elis W, Kunz C, Heidt AB, Herlihy K, Murtie J, Schuller A, Arteaga CL, Sellers WR, Ettenberg SA
(2013) Cancer Res 73: 6024-35
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Breast Neoplasms, Cell Proliferation, ErbB Receptors, Female, Humans, Immunoblotting, Immunoprecipitation, Mice, Mice, Inbred BALB C, Mice, Inbred NOD, Mice, Nude, Mice, SCID, Neuregulin-1, Phosphorylation, Protein Conformation, Protein Multimerization, Proto-Oncogene Proteins c-akt, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Survival Rate, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Added September 3, 2013
0 Communities
2 Members
0 Resources
25 MeSH Terms
Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110α inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers.
Garrett JT, Sutton CR, Kurupi R, Bialucha CU, Ettenberg SA, Collins SD, Sheng Q, Wallweber J, Defazio-Eli L, Arteaga CL
(2013) Cancer Res 73: 6013-23
MeSH Terms: Animals, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Breast Neoplasms, Cell Proliferation, Class I Phosphatidylinositol 3-Kinases, Female, Humans, Immunoblotting, Immunoprecipitation, Lapatinib, Mice, Phosphorylation, Protein Multimerization, Proto-Oncogene Proteins c-akt, Quinazolines, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Survival Rate, Trastuzumab, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Added September 3, 2013
0 Communities
2 Members
0 Resources
23 MeSH Terms
Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.
Young CD, Pfefferle AD, Owens P, Kuba MG, Rexer BN, Balko JM, Sánchez V, Cheng H, Perou CM, Zhao JJ, Cook RS, Arteaga CL
(2013) Cancer Res 73: 4075-85
MeSH Terms: Animals, Antineoplastic Agents, Cell Line, Tumor, Class I Phosphatidylinositol 3-Kinases, Female, Gene Expression, Humans, Hyperplasia, Lapatinib, Mammary Glands, Animal, Mammary Neoplasms, Experimental, Mice, Mice, Nude, Mice, Transgenic, Mutation, Missense, Neoplasm Transplantation, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Protein Binding, Quinazolines, Receptor, ErbB-2, Receptor, ErbB-3, Signal Transduction, Transcriptome, Tumor Burden
Added November 12, 2013
2 Communities
6 Members
0 Resources
25 MeSH Terms
Phase I study of U3-1287, a fully human anti-HER3 monoclonal antibody, in patients with advanced solid tumors.
LoRusso P, Jänne PA, Oliveira M, Rizvi N, Malburg L, Keedy V, Yee L, Copigneaux C, Hettmann T, Wu CY, Ang A, Halim AB, Beckman RA, Beaupre D, Berlin J
(2013) Clin Cancer Res 19: 3078-87
MeSH Terms: Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antibodies, Neutralizing, Antineoplastic Agents, Biomarkers, Broadly Neutralizing Antibodies, Female, Humans, Male, Middle Aged, Neoplasm Staging, Neoplasms, Prognosis, Receptor, ErbB-3, Treatment Outcome
Added March 7, 2014
0 Communities
2 Members
0 Resources
18 MeSH Terms
Dual blockade of HER2 in HER2-overexpressing tumor cells does not completely eliminate HER3 function.
Garrett JT, Sutton CR, Kuba MG, Cook RS, Arteaga CL
(2013) Clin Cancer Res 19: 610-9
MeSH Terms: Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Breast Neoplasms, Cell Line, Tumor, Female, Gene Expression Regulation, Neoplastic, Humans, Lapatinib, Phosphorylation, Protein Kinase Inhibitors, Quinazolines, Receptor, ErbB-2, Receptor, ErbB-3, Trastuzumab, Tumor Burden, Xenograft Model Antitumor Assays
Added September 3, 2013
1 Communities
3 Members
0 Resources
17 MeSH Terms
Update on HER1-3 in advanced non-small-cell lung cancer.
Horn L, Lovly C
(2012) J Thorac Oncol 7: S369-71
MeSH Terms: Antineoplastic Agents, Carcinoma, Non-Small-Cell Lung, Clinical Trials as Topic, ErbB Receptors, Humans, Lung Neoplasms, Molecular Targeted Therapy, Receptor, ErbB-2, Receptor, ErbB-3
Added March 5, 2014
0 Communities
2 Members
0 Resources
9 MeSH Terms
HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation.
Vaught DB, Stanford JC, Young C, Hicks DJ, Wheeler F, Rinehart C, Sánchez V, Koland J, Muller WJ, Arteaga CL, Cook RS
(2012) Cancer Res 72: 2672-82
MeSH Terms: Adenocarcinoma, Animals, Breast Neoplasms, Cell Transformation, Neoplastic, Epithelium, Female, Humans, Hyperplasia, Mice, Mice, Nude, Mice, Transgenic, Phosphatidylinositol 3-Kinases, Receptor, ErbB-2, Receptor, ErbB-3
Added September 3, 2013
2 Communities
3 Members
0 Resources
14 MeSH Terms
The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium.
Balko JM, Miller TW, Morrison MM, Hutchinson K, Young C, Rinehart C, Sánchez V, Jee D, Polyak K, Prat A, Perou CM, Arteaga CL, Cook RS
(2012) Proc Natl Acad Sci U S A 109: 221-6
MeSH Terms: Animals, Biomarkers, Cell Line, Transformed, Cell Proliferation, Cell Survival, Epithelial Cells, Epithelium, Female, Interleukin-6, MAP Kinase Signaling System, Mammary Glands, Animal, Mice, Mitogen-Activated Protein Kinases, Phenotype, Phosphatidylinositol 3-Kinases, Phosphorylation, Receptor, ErbB-3
Added March 5, 2014
2 Communities
3 Members
0 Resources
17 MeSH Terms
ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival.
Zhang Y, Dubé PE, Washington MK, Yan F, Polk DB
(2012) Lab Invest 92: 437-50
MeSH Terms: Animals, Apoptosis, Cell Survival, Colitis, Dextran Sulfate, Epithelial Cells, Female, Intestinal Mucosa, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor, ErbB-2, Receptor, ErbB-3, Tumor Necrosis Factor-alpha
Added March 5, 2014
0 Communities
2 Members
0 Resources
15 MeSH Terms