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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 48

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Molecular imaging of human tumor cells that naturally overexpress type 2 cannabinoid receptors using a quinolone-based near-infrared fluorescent probe.
Wu Z, Shao P, Zhang S, Ling X, Bai M
(2014) J Biomed Opt 19: 76016
MeSH Terms: Biomarkers, Tumor, Fluorescent Dyes, Humans, Jurkat Cells, Molecular Imaging, Molecular Probes, Quinolones, Receptor, Cannabinoid, CB2
Added April 2, 2019
0 Communities
1 Members
0 Resources
MeSH Terms
High proportion of heteroresistance in gyrA and gyrB in fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates.
Eilertson B, Maruri F, Blackman A, Herrera M, Samuels DC, Sterling TR
(2014) Antimicrob Agents Chemother 58: 3270-5
MeSH Terms: Anti-Bacterial Agents, DNA Gyrase, DNA, Bacterial, Drug Resistance, Multiple, Bacterial, Fluoroquinolones, Mutation, Mycobacterium tuberculosis, Phenotype, Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary
Added May 27, 2014
0 Communities
2 Members
0 Resources
10 MeSH Terms
Mechanism of quinolone action and resistance.
Aldred KJ, Kerns RJ, Osheroff N
(2014) Biochemistry 53: 1565-74
MeSH Terms: Animals, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Bacterial Proteins, Drug Resistance, Bacterial, Humans, Quinolones
Added March 13, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy.
Dougherty TJ, Nayar A, Newman JV, Hopkins S, Stone GG, Johnstone M, Shapiro AB, Cronin M, Reck F, Ehmann DE
(2014) Antimicrob Agents Chemother 58: 2657-64
MeSH Terms: Anti-Bacterial Agents, DNA Gyrase, DNA Topoisomerase IV, Escherichia coli, Fluoroquinolones, Gram-Negative Bacteria, Microbial Sensitivity Tests, Morpholines, Naphthyridines, Topoisomerase II Inhibitors
Added March 20, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
Aldred KJ, Schwanz HA, Li G, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
(2013) ACS Chem Biol 8: 2660-8
MeSH Terms: Anti-Bacterial Agents, Antigens, Neoplasm, Bacillus anthracis, Cations, Divalent, DNA Cleavage, DNA Topoisomerase IV, DNA Topoisomerases, Type II, DNA, Bacterial, DNA-Binding Proteins, Drug Resistance, Bacterial, Humans, Kinetics, Magnesium, Mutation, Quinazolinones, Quinolones, Recombinant Proteins, Species Specificity, Structure-Activity Relationship, Water
Added March 7, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Fluoroquinolone susceptibility in Mycobacterium tuberculosis after pre-diagnosis exposure to older- versus newer-generation fluoroquinolones.
van der Heijden YF, Maruri F, Blackman A, Mitchel E, Bian A, Shintani AK, Eden S, Warkentin JV, Sterling TR
(2013) Int J Antimicrob Agents 42: 232-7
MeSH Terms: Adult, Aged, Anti-Bacterial Agents, Aza Compounds, Case-Control Studies, Ciprofloxacin, DNA Gyrase, Drug Resistance, Bacterial, Female, Fluoroquinolones, Gatifloxacin, Humans, Levofloxacin, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Mycobacterium tuberculosis, Ofloxacin, Quinolines, Tuberculosis
Added May 29, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.
Aldred KJ, McPherson SA, Turnbough CL, Kerns RJ, Osheroff N
(2013) Nucleic Acids Res 41: 4628-39
MeSH Terms: Anti-Bacterial Agents, Bacillus anthracis, Cations, Divalent, Ciprofloxacin, DNA, DNA Cleavage, DNA Topoisomerase IV, Drug Resistance, Magnesium, Metals, Mutation, Quinazolinones, Quinolones, Water
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Fluoroquinolone exposure prior to tuberculosis diagnosis is associated with an increased risk of death.
van der Heijden YF, Maruri F, Blackman A, Holt E, Warkentin JV, Shepherd BE, Sterling TR
(2012) Int J Tuberc Lung Dis 16: 1162-7
MeSH Terms: Adult, Age Factors, Aged, Anti-Bacterial Agents, Antitubercular Agents, Coinfection, Drug Resistance, Multiple, Bacterial, Female, Fluoroquinolones, HIV Infections, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Multivariate Analysis, Mycobacterium tuberculosis, Odds Ratio, Prospective Studies, Risk Assessment, Risk Factors, Sputum, Tennessee, Time Factors, Treatment Outcome, Tuberculosis, Pulmonary
Added May 29, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Buckner FS, Bahia MT, Suryadevara PK, White KL, Shackleford DM, Chennamaneni NK, Hulverson MA, Laydbak JU, Chatelain E, Scandale I, Verlinde CL, Charman SA, Lepesheva GI, Gelb MH
(2012) Antimicrob Agents Chemother 56: 4914-21
MeSH Terms: 14-alpha Demethylase Inhibitors, Administration, Oral, Alkyl and Aryl Transferases, Animals, Chagas Disease, Crystallography, X-Ray, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Administration Schedule, Female, Humans, Mice, Models, Molecular, Nitroimidazoles, Quinolones, Structure-Activity Relationship, Triazoles, Trypanocidal Agents, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Microcolonies in fluoroquinolone agar proportion susceptibility testing of Mycobacterium tuberculosis: an indicator of drug resistance.
Blackman A, May S, Devasia RA, Maruri F, Stratton C, Sterling TR
(2012) Eur J Clin Microbiol Infect Dis 31: 2177-82
MeSH Terms: Agar, Antitubercular Agents, Culture Media, Drug Resistance, Bacterial, Fluoroquinolones, Humans, Microbial Sensitivity Tests, Mycobacterium tuberculosis
Added May 29, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms