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Results: 11 to 20 of 122

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The MYC-WDR5 Nexus and Cancer.
Thomas LR, Foshage AM, Weissmiller AM, Tansey WP
(2015) Cancer Res 75: 4012-5
MeSH Terms: Antineoplastic Agents, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Chromatin Assembly and Disassembly, DNA, DNA Methylation, Drug Discovery, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Genes, myc, Histone-Lysine N-Methyltransferase, Histones, Humans, Intracellular Signaling Peptides and Proteins, Models, Genetic, Molecular Targeted Therapy, Neoplasm Proteins, Neoplasms, Protein Binding, Proto-Oncogene Proteins c-myc, Repressor Proteins, Signal Transduction
Added March 26, 2019
0 Communities
1 Members
0 Resources
21 MeSH Terms
Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.
Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP
(2015) Mol Cell 58: 440-52
MeSH Terms: Amino Acid Motifs, Amino Acid Sequence, Animals, Anisotropy, Binding Sites, Carcinogenesis, Chromatin, Fluorescence Polarization, HEK293 Cells, Humans, Intracellular Signaling Peptides and Proteins, Mice, Mice, Nude, Models, Molecular, Molecular Sequence Data, Mutation, NIH 3T3 Cells, Protein Binding, Protein Structure, Tertiary, Proteins, Proto-Oncogene Proteins c-myc, Sequence Homology, Amino Acid, Two-Hybrid System Techniques
Added May 15, 2015
0 Communities
3 Members
0 Resources
23 MeSH Terms
Tagging strategies strongly affect the fate of overexpressed caveolin-1.
Han B, Tiwari A, Kenworthy AK
(2015) Traffic 16: 417-38
MeSH Terms: Animals, COS Cells, Caveolin 1, Caveolin 2, Cell Line, Cell Line, Tumor, Cell Membrane, Chlorocebus aethiops, Endocytosis, Green Fluorescent Proteins, HeLa Cells, Humans, Luminescent Proteins, Mechanotransduction, Cellular, Proto-Oncogene Proteins c-myc
Added February 13, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
A common functional consequence of tumor-derived mutations within c-MYC.
Chakraborty AA, Scuoppo C, Dey S, Thomas LR, Lorey SL, Lowe SW, Tansey WP
(2015) Oncogene 34: 2406-9
MeSH Terms: Amino Acid Sequence, Animals, Cell Line, Tumor, Conserved Sequence, DNA, Humans, Lymphoma, Mice, Mutation, Missense, NIH 3T3 Cells, Proto-Oncogene Proteins c-myc
Added February 12, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Oncogenic protein MTBP interacts with MYC to promote tumorigenesis.
Grieb BC, Gramling MW, Arrate MP, Chen X, Beauparlant SL, Haines DS, Xiao H, Eischen CM
(2014) Cancer Res 74: 3591-602
MeSH Terms: 3T3 Cells, ATPases Associated with Diverse Cellular Activities, Animals, Apoptosis, Breast Neoplasms, Carrier Proteins, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic, DNA Helicases, Female, Gene Dosage, HEK293 Cells, Humans, Mice, Mice, Nude, Protein Binding, Proto-Oncogene Proteins c-mdm2, Proto-Oncogene Proteins c-myc, Rats
Added May 27, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Cytogenetic prognostication within medulloblastoma subgroups.
Shih DJ, Northcott PA, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc AM, Garzia L, Peacock J, Mack SC, Wu X, Rolider A, Morrissy AS, Cavalli FM, Jones DT, Zitterbart K, Faria CC, Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan JA, Robinson S, Bognár L, Klekner A, Saad AG, Liau LM, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper MK, Thompson RC, Bailey S, Lindsey JC, Di Rocco C, Massimi L, Michiels EM, Scherer SW, Phillips JJ, Gupta N, Fan X, Muraszko KM, Vibhakar R, Eberhart CG, Fouladi M, Lach B, Jung S, Wechsler-Reya RJ, Fèvre-Montange M, Jouvet A, Jabado N, Pollack IF, Weiss WA, Lee JY, Cho BK, Kim SK, Wang KC, Leonard JR, Rubin JB, de Torres C, Lavarino C, Mora J, Cho YJ, Tabori U, Olson JM, Gajjar A, Packer RJ, Rutkowski S, Pomeroy SL, French PJ, Kloosterhof NK, Kros JM, Van Meir EG, Clifford SC, Bourdeaut F, Delattre O, Doz FF, Hawkins CE, Malkin D, Grajkowska WA, Perek-Polnik M, Bouffet E, Rutka JT, Pfister SM, Taylor MD
(2014) J Clin Oncol 32: 886-96
MeSH Terms: Adolescent, Biomarkers, Tumor, Child, Child, Preschool, Chromosomes, Human, Pair 11, Chromosomes, Human, Pair 14, Cytogenetics, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hedgehog Proteins, Humans, In Situ Hybridization, Fluorescence, Infant, Kruppel-Like Transcription Factors, Male, Medulloblastoma, Nuclear Proteins, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Proto-Oncogene Proteins c-myc, Reproducibility of Results, Risk Assessment, Risk Factors, Tissue Array Analysis, Wnt Proteins, Young Adult, Zinc Finger Protein Gli2
Added March 21, 2014
0 Communities
1 Members
0 Resources
29 MeSH Terms
A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells.
Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco OE, Cates JM, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R
(2013) Eur Urol 64: 753-61
MeSH Terms: Aged, Biomarkers, Cell Differentiation, Cell Lineage, Cell Separation, Cells, Cultured, Cellular Reprogramming, Female, Gene Expression Regulation, Developmental, Humans, Induced Pluripotent Stem Cells, Kallikreins, Kruppel-Like Factor 4, Kruppel-Like Transcription Factors, Male, Middle Aged, Octamer Transcription Factor-3, Prostate, Prostate-Specific Antigen, Proto-Oncogene Proteins c-myc, Receptors, Androgen, Regeneration, SOXB1 Transcription Factors, Time Factors, Tissue Engineering, Transfection, Ureter, Urinary Bladder, Uroplakins
Added March 7, 2014
0 Communities
2 Members
0 Resources
29 MeSH Terms
Inhibition of BET bromodomain targets genetically diverse glioblastoma.
Cheng Z, Gong Y, Ma Y, Lu K, Lu X, Pierce LA, Thompson RC, Muller S, Knapp S, Wang J
(2013) Clin Cancer Res 19: 1748-59
MeSH Terms: Animals, Azepines, Cell Line, Tumor, Cell Proliferation, Cell Survival, Disease Models, Animal, Disease Progression, Drug Resistance, Neoplasm, Female, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Glioblastoma, Humans, Mice, Protein Kinase Inhibitors, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-myc, RNA Interference, Signal Transduction, Transcription, Genetic, Triazoles, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity.
Zhang Q, Spears E, Boone DN, Li Z, Gregory MA, Hann SR
(2013) Proc Natl Acad Sci U S A 110: 978-83
MeSH Terms: Amino Acid Substitution, Animals, Apoptosis, Binding, Competitive, Cell Transformation, Neoplastic, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p16, Early Growth Response Protein 1, Gene Knockout Techniques, Genes, myc, HeLa Cells, Humans, Mice, Mutagenesis, Site-Directed, Protein Structure, Tertiary, Proto-Oncogene Proteins c-myc, S-Phase Kinase-Associated Proteins, Transcription, Genetic, Ubiquitination
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells.
Murphy TA, Dang CV, Young JD
(2013) Metab Eng 15: 206-17
MeSH Terms: B-Lymphocytes, Carbon Isotopes, Cell Line, Glucose, Humans, Magnetic Resonance Spectroscopy, Proto-Oncogene Proteins c-myc
Added January 23, 2015
0 Communities
1 Members
0 Resources
7 MeSH Terms