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Results: 11 to 20 of 69

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Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction.
Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA
(2008) J Clin Invest 118: 2121-31
MeSH Terms: Arachidonic Acid, Blood Platelets, Calcium, Eicosanoids, Group IV Phospholipases A2, Heterozygote, Humans, Intestine, Small, Ionophores, Male, Middle Aged, Models, Biological, Prostaglandin D2, Prostaglandin-Endoperoxide Synthases, Thromboxane A2, Ulcer
Added December 10, 2013
2 Communities
3 Members
0 Resources
16 MeSH Terms
Cyclopentenone prostaglandin, 15-deoxy-Delta12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione.
Brunoldi EM, Zanoni G, Vidari G, Sasi S, Freeman ML, Milne GL, Morrow JD
(2007) Chem Res Toxicol 20: 1528-35
MeSH Terms: Carcinoma, Hepatocellular, Cell Line, Tumor, Chromatography, High Pressure Liquid, Glutathione, Hepatocytes, Humans, Metabolic Detoxication, Phase II, Prostaglandin D2, Spectrometry, Mass, Electrospray Ionization
Added March 5, 2014
0 Communities
2 Members
0 Resources
9 MeSH Terms
Induction and function of lipocalin prostaglandin D synthase in host immunity.
Joo M, Kwon M, Sadikot RT, Kingsley PJ, Marnett LJ, Blackwell TS, Peebles RS, Urade Y, Christman JW
(2007) J Immunol 179: 2565-75
MeSH Terms: Animals, Atherosclerosis, Cell Line, Epigenesis, Genetic, Gene Expression Regulation, Enzymologic, Immunity, Innate, Intramolecular Oxidoreductases, Lipocalins, Lipopolysaccharides, Macrophages, Mice, Mice, Knockout, Pneumonia, Bacterial, Prostaglandin D2, Pseudomonas Infections, Pseudomonas aeruginosa, Transcription Factor AP-1, Tumor Suppressor Protein p53
Added March 5, 2014
1 Communities
3 Members
0 Resources
18 MeSH Terms
Biochemical diagnosis of systemic mast cell disorders.
Roberts LJ, Oates JA
(1991) J Invest Dermatol 96: 19S-24S; discussion 24S-25S; 60S-65S
MeSH Terms: Flushing, Heparin, Histamine, Humans, Mastocytosis, Systemic, Prostaglandin D2, Tryptases
Added December 10, 2013
0 Communities
2 Members
0 Resources
7 MeSH Terms
Interaction of electrophilic lipid oxidation products with mitochondria in endothelial cells and formation of reactive oxygen species.
Landar A, Zmijewski JW, Dickinson DA, Le Goffe C, Johnson MS, Milne GL, Zanoni G, Vidari G, Morrow JD, Darley-Usmar VM
(2006) Am J Physiol Heart Circ Physiol 290: H1777-87
MeSH Terms: Aldehydes, Animals, Cattle, Cells, Cultured, Endothelial Cells, Gene Expression Regulation, Lipid Metabolism, Lipid Peroxidation, Mitochondria, Mitochondrial Proteins, Prostaglandin D2, Reactive Oxygen Species, Signal Transduction
Added March 26, 2014
1 Communities
1 Members
0 Resources
13 MeSH Terms
Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production.
Hwang J, Kleinhenz DJ, Lass├Ęgue B, Griendling KK, Dikalov S, Hart CM
(2005) Am J Physiol Cell Physiol 288: C899-905
MeSH Terms: Blotting, Western, Cell Membrane, Cells, Cultured, Electron Spin Resonance Spectroscopy, Endothelial Cells, Humans, Hypoglycemic Agents, Ligands, NADPH Oxidases, Nitric Oxide, PPAR gamma, Prostaglandin D2, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Superoxide Dismutase, Superoxides, Thiazolidinediones, Umbilical Veins
Added February 17, 2016
0 Communities
1 Members
0 Resources
18 MeSH Terms
Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.
Hata AN, Lybrand TP, Marnett LJ, Breyer RM
(2005) Mol Pharmacol 67: 640-7
MeSH Terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Cell Movement, Cyclic AMP, Ecdysterone, Humans, Indomethacin, Kidney, Mice, Prostaglandin D2, Radioligand Assay, Receptors, Immunologic, Receptors, Prostaglandin, Recombinant Proteins, Transfection, Tritium
Added December 21, 2013
0 Communities
2 Members
0 Resources
17 MeSH Terms
Formation of prostaglandins E2 and D2 via the isoprostane pathway: a mechanism for the generation of bioactive prostaglandins independent of cyclooxygenase.
Gao L, Zackert WE, Hasford JJ, Danekis ME, Milne GL, Remmert C, Reese J, Yin H, Tai HH, Dey SK, Porter NA, Morrow JD
(2003) J Biol Chem 278: 28479-89
MeSH Terms: Animals, Arachidonic Acid, Carbon Tetrachloride, Chromatography, High Pressure Liquid, Dinoprostone, Drug Stability, Esterification, Gas Chromatography-Mass Spectrometry, Humans, Hydrolysis, Isomerism, Isoprostanes, Liver, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Oxidative Stress, Phospholipids, Prostaglandin D2, Rats
Added March 26, 2014
0 Communities
3 Members
0 Resources
19 MeSH Terms
Expression and molecular pharmacology of the mouse CRTH2 receptor.
Hata AN, Zent R, Breyer MD, Breyer RM
(2003) J Pharmacol Exp Ther 306: 463-70
MeSH Terms: Animals, Cell Movement, Cells, Cultured, Humans, Ligands, Mice, Prostaglandin D2, Radioligand Assay, Receptors, Immunologic, Receptors, Prostaglandin, Signal Transduction, Tritium
Added December 21, 2013
1 Communities
2 Members
0 Resources
12 MeSH Terms
Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione.
Cox B, Murphey LJ, Zackert WE, Chinery R, Graves-Deal R, Boutaud O, Oates JA, Coffey RJ, Morrow JD
(2002) Biochim Biophys Acta 1584: 37-45
MeSH Terms: Antineoplastic Agents, Chromatography, Liquid, Colorectal Neoplasms, Cyclopentanes, Glutathione, Humans, Mass Spectrometry, Prostaglandin D2, Time Factors, Tumor Cells, Cultured
Added December 10, 2013
1 Communities
3 Members
0 Resources
10 MeSH Terms