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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 23

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The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo.
Riggs DL, Roberts PJ, Chirillo SC, Cheung-Flynn J, Prapapanich V, Ratajczak T, Gaber R, Picard D, Smith DF
(2003) EMBO J 22: 1158-67
MeSH Terms: Animals, Dose-Response Relationship, Drug, Gene Expression Regulation, Genes, Reporter, Glucocorticoids, HSP90 Heat-Shock Proteins, Humans, Models, Molecular, Molecular Chaperones, Peptidylprolyl Isomerase, Protein Binding, Protein Conformation, Receptors, Glucocorticoid, Saccharomyces cerevisiae, Signal Transduction, Tacrolimus Binding Proteins, Transcriptional Activation
Added March 9, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Retention of immunosuppressant activity in an ascomycin analogue lacking a hydrogen-bonding interaction with FKBP12.
Wiedeman PE, Fesik SW, Petros AM, Nettesheim DG, Mollison KW, Lane BC, Or YS, Luly JR
(1999) J Med Chem 42: 4456-61
MeSH Terms: Amino Acid Sequence, Animals, Humans, Hyperplasia, Immunophilins, Immunosuppressive Agents, Lymph Nodes, Lymphocyte Culture Test, Mixed, Magnetic Resonance Spectroscopy, Male, Models, Molecular, Molecular Sequence Data, Nucleotidyltransferases, Peptidylprolyl Isomerase, Protein Binding, Rats, Rats, Inbred Lew, Rats, Sprague-Dawley, Recombinant Fusion Proteins, Tacrolimus, Tacrolimus Binding Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.
Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA
(1999) Oncogene 18: 1219-26
MeSH Terms: Animals, Bacterial Proteins, Base Sequence, Cell Transformation, Neoplastic, Conserved Sequence, DNA-Binding Proteins, Gene Expression Regulation, Humans, Mice, Molecular Sequence Data, Peptidylprolyl Isomerase, Promoter Regions, Genetic, Protein Biosynthesis, Proteins, Proto-Oncogene Proteins c-myc, RNA, RNA-Directed DNA Polymerase, Rats, Sequence Homology, Nucleic Acid, Telomerase, Transcription, Genetic
Added March 20, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity.
Aiken C
(1998) Virology 248: 139-47
MeSH Terms: Cell Line, Cyclosporine, Defective Viruses, Gene Products, nef, Genes, nef, HIV-1, HeLa Cells, Humans, Peptidylprolyl Isomerase, T-Lymphocytes, Tumor Cells, Cultured, Virion, Virus Replication, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.
Aiken C
(1997) J Virol 71: 5871-7
MeSH Terms: Amino Acid Isomerases, Carrier Proteins, Cyclosporine, Endocytosis, Gene Products, gag, Gene Products, nef, HIV-1, Humans, Immunosuppressive Agents, Membrane Glycoproteins, Peptidylprolyl Isomerase, Viral Envelope Proteins, nef Gene Products, Human Immunodeficiency Virus
Added February 19, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Solution structure of the cyclosporin A/cyclophilin complex by NMR.
Thériault Y, Logan TM, Meadows R, Yu L, Olejniczak ET, Holzman TF, Simmer RL, Fesik SW
(1993) Nature 361: 88-91
MeSH Terms: Amino Acid Isomerases, Carrier Proteins, Cyclosporine, Cyclosporins, Magnetic Resonance Spectroscopy, Models, Molecular, Peptidylprolyl Isomerase, Protein Conformation, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Nuclear magnetic resonance methods for studying protein-ligand complexes.
Petros AM, Fesik SW
(1994) Methods Enzymol 239: 717-39
MeSH Terms: Amino Acid Isomerases, Animals, Binding Sites, Carbon Isotopes, Carrier Proteins, Cyclosporine, DNA-Binding Proteins, Deuterium, Heat-Shock Proteins, Hydrogen, Ligands, Macromolecular Substances, Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Probes, Molecular Structure, Nitrogen Isotopes, Peptidylprolyl Isomerase, Protein Binding, Proteins, Tacrolimus, Tacrolimus Binding Proteins, Thermodynamics
Added March 5, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
pH titration of the histidine residues of cyclophilin and FK506 binding protein in the absence and presence of immunosuppressant ligands.
Yu L, Fesik SW
(1994) Biochim Biophys Acta 1209: 24-32
MeSH Terms: Amino Acid Isomerases, Carrier Proteins, Cyclosporine, Electrochemistry, Heat-Shock Proteins, Histidine, Humans, Hydrogen-Ion Concentration, Immunosuppressive Agents, Ligands, Magnetic Resonance Spectroscopy, Peptidylprolyl Isomerase, Protein Conformation, Recombinant Proteins, Tacrolimus, Tacrolimus Binding Proteins, Titrimetry
Added March 5, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9,10 amide bond.
Fesik SW, Gampe RT, Holzman TF, Egan DA, Edalji R, Luly JR, Simmer R, Helfrich R, Kishore V, Rich DH
(1990) Science 250: 1406-9
MeSH Terms: Amides, Amino Acid Isomerases, Carbon Isotopes, Carrier Proteins, Cyclosporins, Escherichia coli, Humans, Leucine, Magnetic Resonance Spectroscopy, Peptidylprolyl Isomerase, Phenylalanine, Protein Binding, Protein Conformation, Recombinant Proteins, Tryptophan
Added March 5, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
NMR studies of [U-13C]cyclosporin A bound to cyclophilin: bound conformation and portions of cyclosporin involved in binding.
Fesik SW, Gampe RT, Eaton HL, Gemmecker G, Olejniczak ET, Neri P, Holzman TF, Egan DA, Edalji R, Simmer R
(1991) Biochemistry 30: 6574-83
MeSH Terms: Amino Acid Isomerases, Amino Acid Sequence, Binding Sites, Calorimetry, Carbon Isotopes, Carrier Proteins, Cyclosporins, Humans, Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Conformation, Peptidylprolyl Isomerase, Protein Conformation, Recombinant Proteins
Added March 5, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms