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Results: 11 to 20 of 53

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Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss.
Jolly LA, Novitskiy S, Owens P, Massoll N, Cheng N, Fang W, Moses HL, Franco AT
(2016) Cancer Res 76: 1804-13
MeSH Terms: Cell Proliferation, Collagen, Fibroblasts, Humans, PTEN Phosphohydrolase, Proto-Oncogene Proteins B-raf, Thyroid Neoplasms, Tumor Microenvironment
Added February 5, 2016
1 Communities
2 Members
0 Resources
8 MeSH Terms
Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.
Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ
(2015) J Pathol 236: 421-32
MeSH Terms: Animals, Apoptosis, Aristolochic Acids, Cell Cycle Checkpoints, Cell Line, Cell Proliferation, Disease Models, Animal, Enzyme Inhibitors, Fibrosis, Gene Expression Regulation, Humans, Kidney Diseases, Kidney Tubules, Male, Mice, Inbred C57BL, PTEN Phosphohydrolase, Plasminogen Activator Inhibitor 1, RNA Interference, Signal Transduction, Smad3 Protein, Streptozocin, Transfection, Transforming Growth Factor beta1, Tumor Suppressor Protein p53, Ureteral Obstruction
Added April 19, 2016
0 Communities
1 Members
0 Resources
25 MeSH Terms
Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer.
Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol JA, Cardiff RD, Muthuswamy SK
(2014) Cancer Res 74: 3180-94
MeSH Terms: Animals, Breast Neoplasms, Carcinogenesis, Cell Line, Cell Line, Tumor, Cell Polarity, Class I Phosphatidylinositol 3-Kinases, Female, Gene Expression, HEK293 Cells, Humans, Membrane Proteins, Mice, Mice, Transgenic, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Tumor Suppressor Proteins
Added May 20, 2014
1 Communities
2 Members
0 Resources
20 MeSH Terms
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy.
Shi H, Hugo W, Kong X, Hong A, Koya RC, Moriceau G, Chodon T, Guo R, Johnson DB, Dahlman KB, Kelley MC, Kefford RF, Chmielowski B, Glaspy JA, Sosman JA, van Baren N, Long GV, Ribas A, Lo RS
(2014) Cancer Discov 4: 80-93
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Cell Line, Tumor, Clonal Evolution, Drug Resistance, Neoplasm, Female, Humans, Imidazoles, Indoles, Male, Melanoma, Middle Aged, Mitogen-Activated Protein Kinases, Oximes, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Skin Neoplasms, Sulfonamides, Vemurafenib, ras Proteins
Added March 20, 2014
0 Communities
3 Members
0 Resources
25 MeSH Terms
Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels.
Mikhitarian K, Pollen M, Zhao Z, Shyr Y, Merchant NB, Parikh A, Revetta F, Washington MK, Vnencak-Jones C, Shi C
(2014) Mod Pathol 27: 665-74
MeSH Terms: Adenocarcinoma, Aged, Ampulla of Vater, Class I Phosphatidylinositol 3-Kinases, Common Bile Duct Neoplasms, DNA Mutational Analysis, Duodenal Neoplasms, ErbB Receptors, Female, Humans, Male, Middle Aged, PTEN Phosphohydrolase, Pancreatic Neoplasms, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Signal Transduction, ras Proteins
Added March 7, 2014
0 Communities
4 Members
0 Resources
19 MeSH Terms
Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling.
Paul P, Qiao J, Kim KW, Romain C, Lee S, Volny N, Mobley B, Correa H, Chung DH
(2013) PLoS One 8: e72570
MeSH Terms: Animals, Cell Adhesion, Cell Line, Tumor, Cell Movement, Disease Progression, Enzyme Activation, Gastrin-Releasing Peptide, Gene Knockdown Techniques, Human Umbilical Vein Endothelial Cells, Humans, Liver Neoplasms, Male, Mice, Mice, Nude, Neoplasm Transplantation, Neovascularization, Pathologic, Neuroblastoma, PTEN Phosphohydrolase, Phenotype, Proto-Oncogene Proteins c-akt, RNA Interference, RNA, Small Interfering, Signal Transduction
Added March 7, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
Phosphatase and tensin homolog deficiency and resistance to trastuzumab and chemotherapy.
Rexer BN, Shyr Y, Arteaga CL
(2013) J Clin Oncol 31: 2073-5
MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Breast Neoplasms, Female, Humans, PTEN Phosphohydrolase, Receptor, ErbB-2
Added September 3, 2013
0 Communities
4 Members
0 Resources
6 MeSH Terms
Differential regulation of cyclin-dependent kinase inhibitors in neuroblastoma cells.
Qiao L, Paul P, Lee S, Qiao J, Wang Y, Chung DH
(2013) Biochem Biophys Res Commun 435: 295-9
MeSH Terms: Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, Cyclin-Dependent Kinase Inhibitor p27, Gastrin-Releasing Peptide, Gene Expression Regulation, Neoplastic, Humans, Neuroblastoma, PTEN Phosphohydrolase, Receptors, Bombesin
Added March 7, 2014
0 Communities
1 Members
0 Resources
9 MeSH Terms
Deficiency in metabolic regulators PPARγ and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration.
Strand DW, DeGraff DJ, Jiang M, Sameni M, Franco OE, Love HD, Hayward WJ, Lin-Tsai O, Wang AY, Cates JM, Sloane BF, Matusik RJ, Hayward SW
(2013) Am J Pathol 182: 449-59
MeSH Terms: Adult, Animals, Base Sequence, Cell Line, Cell Transdifferentiation, Coculture Techniques, Epithelial Cells, Humans, Hyperplasia, Mesoderm, Metaplasia, Mice, Models, Biological, Molecular Sequence Data, PPAR gamma, PTEN Phosphohydrolase, Regeneration, Urothelium
Added December 10, 2013
1 Communities
4 Members
0 Resources
18 MeSH Terms
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.
Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK
(2012) Nat Genet 44: 1104-10
MeSH Terms: Amino Acid Substitution, Animals, CREB-Binding Protein, Cell Line, Tumor, DNA Copy Number Variations, DNA Mutational Analysis, E1A-Associated p300 Protein, Gene Expression Profiling, Gene Regulatory Networks, Genome, Human, Genome-Wide Association Study, Histone-Lysine N-Methyltransferase, Humans, Intercellular Signaling Peptides and Proteins, Lung Neoplasms, Mice, Mice, Knockout, Models, Molecular, Mutation, Myeloid-Lymphoid Leukemia Protein, Nerve Tissue Proteins, Oligonucleotide Array Sequence Analysis, PTEN Phosphohydrolase, Polymorphism, Single Nucleotide, Protein Processing, Post-Translational, Retinoblastoma Protein, Small Cell Lung Carcinoma, Tumor Suppressor Protein p53
Added September 3, 2013
0 Communities
2 Members
0 Resources
28 MeSH Terms