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Results: 11 to 19 of 19

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Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP
(2004) Chem Res Toxicol 17: 972-82
MeSH Terms: Biotransformation, Dose-Response Relationship, Drug, Escherichia coli, Humans, Hydrocarbons, Halogenated, Mutagenicity Tests, Mutagens, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Salmonella typhimurium, Structure-Activity Relationship
Added March 5, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.
Liu L, Williams KM, Guengerich FP, Pegg AE
(2004) Chem Res Toxicol 17: 742-52
MeSH Terms: DNA Damage, DNA-Directed RNA Polymerases, Electrophoresis, Polyacrylamide Gel, Escherichia coli, Hydrocarbons, Brominated, Mass Spectrometry, Mutagenicity Tests, O(6)-Methylguanine-DNA Methyltransferase, Plasmids, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Added May 26, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer.
Gutiérrez MI, Siraj AK, Khaled H, Koon N, El-Rifai W, Bhatia K
(2004) Mod Pathol 17: 1268-74
MeSH Terms: Acid Anhydride Hydrolases, Adenomatous Polyposis Coli Protein, Apoptosis Regulatory Proteins, Cadherins, Calcium-Calmodulin-Dependent Protein Kinases, Carcinoma, Squamous Cell, Cell Cycle Proteins, CpG Islands, Cyclin-Dependent Kinase Inhibitor p15, Cyclin-Dependent Kinase Inhibitor p16, DNA Methylation, DNA-Binding Proteins, Death-Associated Protein Kinases, Genes, Tumor Suppressor, Glutathione S-Transferase pi, Glutathione Transferase, Humans, Isoenzymes, Neoplasm Proteins, Nuclear Proteins, O(6)-Methylguanine-DNA Methyltransferase, Polymerase Chain Reaction, Receptors, Retinoic Acid, Schistosomiasis haematobia, Tumor Protein p73, Tumor Suppressor Protein p14ARF, Tumor Suppressor Proteins, Urinary Bladder Neoplasms
Added March 5, 2014
0 Communities
1 Members
0 Resources
28 MeSH Terms
Cloning and expression of canine O6-methylguanine-DNA methyltransferase in target cells, using gammaretroviral and lentiviral vectors.
Zaboikin M, Srinivasakumar N, Zaboikina T, Schuening F
(2004) Hum Gene Ther 15: 383-92
MeSH Terms: Amino Acid Sequence, Animals, Base Sequence, Carmustine, Cell Division, Cells, Cultured, Cloning, Molecular, Dogs, Genetic Vectors, HIV-1, Humans, Kidney, Lentivirus, Molecular Sequence Data, Moloney murine leukemia virus, Mutation, O(6)-Methylguanine-DNA Methyltransferase, Retroviridae, Sequence Homology, Amino Acid
Added June 15, 2010
0 Communities
1 Members
0 Resources
19 MeSH Terms
Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE
(2004) J Biol Chem 279: 4250-9
MeSH Terms: Animals, Cattle, DNA Adducts, Ethylene Dibromide, Humans, In Vitro Techniques, Molecular Structure, Mutagens, O(6)-Methylguanine-DNA Methyltransferase, Recombinant Proteins, Salmonella typhimurium, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Added March 20, 2014
0 Communities
2 Members
0 Resources
12 MeSH Terms
O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.
Guengerich FP, Fang Q, Liu L, Hachey DL, Pegg AE
(2003) Biochemistry 42: 10965-70
MeSH Terms: Anions, Binding Sites, Catalysis, Cysteine, DNA Repair, Dinitrochlorobenzene, Disulfides, Dose-Response Relationship, Drug, Escherichia coli, Hydrogen-Ion Concentration, Kinetics, O(6)-Methylguanine-DNA Methyltransferase, Pyridines, Spectrophotometry, Time Factors, Ultraviolet Rays, Zinc
Added March 5, 2014
0 Communities
2 Members
0 Resources
17 MeSH Terms
Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine.
Tserng KY, Ingalls ST, Boczko EM, Spiro TP, Li X, Majka S, Gerson SL, Willson JK, Hoppel CL
(2003) J Clin Pharmacol 43: 881-93
MeSH Terms: Aged, Antineoplastic Agents, Alkylating, Carmustine, Enzyme Inhibitors, Female, Guanine, Half-Life, Humans, Infusions, Intravenous, Male, Metabolic Clearance Rate, Middle Aged, Models, Biological, Neoplasms, O(6)-Methylguanine-DNA Methyltransferase
Added August 4, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Activation of dihaloalkanes by thiol-dependent mechanisms.
Guengerich FP
(2003) J Biochem Mol Biol 36: 20-7
MeSH Terms: DNA Adducts, Ethylene Dibromide, Glutathione, Humans, Hydrocarbons, Halogenated, Inactivation, Metabolic, O(6)-Methylguanine-DNA Methyltransferase, Sulfhydryl Compounds
Added March 5, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
Liu L, Pegg AE, Williams KM, Guengerich FP
(2002) J Biol Chem 277: 37920-8
MeSH Terms: Amino Acid Substitution, Base Sequence, Cell Line, Cloning, Molecular, DNA Primers, DNA Repair, Escherichia coli, Ethylene Dibromide, Humans, Kinetics, Mutagenesis, Site-Directed, O(6)-Methylguanine-DNA Methyltransferase, Plasmids, Recombinant Proteins
Added May 26, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms