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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 39

Publication Record

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Long QT Syndrome and Potentially Pathogenic Genetic Variants--In Reply.
Van Driest SL, Wells QS, Roden DM
(2016) JAMA 315: 2467-8
MeSH Terms: Arrhythmias, Cardiac, Electronic Health Records, Ether-A-Go-Go Potassium Channels, Female, Genetic Variation, Humans, Laboratories, Male, NAV1.5 Voltage-Gated Sodium Channel, Phenotype
Added April 6, 2017
0 Communities
2 Members
0 Resources
10 MeSH Terms
Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, Kullo IJ, Abul-Husn NS, Scott SA, Bottinger E, Almoguera B, Connolly J, Chiavacci R, Hakonarson H, Rasmussen-Torvik LJ, Pan V, Persell SD, Smith M, Chisholm RL, Kitchner TE, He MM, Brilliant MH, Wallace JR, Doheny KF, Shoemaker MB, Li R, Manolio TA, Callis TE, Macaya D, Williams MS, Carey D, Kapplinger JD, Ackerman MJ, Ritchie MD, Denny JC, Roden DM
(2016) JAMA 315: 47-57
MeSH Terms: Aged, Aged, 80 and over, Alleles, Arrhythmias, Cardiac, Brugada Syndrome, ERG1 Potassium Channel, Electronic Health Records, Ether-A-Go-Go Potassium Channels, Female, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Genomics, Heterozygote, Humans, Incidental Findings, Laboratories, Male, Middle Aged, Mutation, Missense, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Prospective Studies, Random Allocation, Statistics, Nonparametric, Young Adult
Added April 6, 2017
0 Communities
4 Members
0 Resources
26 MeSH Terms
Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.
Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM
(2014) Circulation 130: 224-34
MeSH Terms: 4-Aminopyridine, Action Potentials, Animals, CHO Cells, Cells, Cultured, Cricetinae, Cricetulus, Drug Evaluation, Preclinical, Female, HEK293 Cells, Humans, Mice, Mice, Inbred C57BL, Models, Animal, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Patch-Clamp Techniques, Phenethylamines, Phosphatidylinositol 3-Kinases, Potassium Channel Blockers, Proto-Oncogene Proteins c-akt, Risk Factors, Signal Transduction, Sulfonamides, Torsades de Pointes, Transfection
Added June 5, 2014
0 Communities
2 Members
0 Resources
26 MeSH Terms
Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.
Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA
(2013) Am J Physiol Heart Circ Physiol 305: H1068-79
MeSH Terms: Acetanilides, Animals, Calcium Channels, L-Type, Calcium Signaling, Disease Models, Animal, Disease Progression, Dose-Response Relationship, Drug, Heart Failure, Hypertension, Hypertrophy, Left Ventricular, Male, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Piperazines, Ranolazine, Rats, Rats, Inbred SHR, Ryanodine Receptor Calcium Release Channel, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Sodium, Sodium Channel Blockers, Sodium Channels, Sodium-Calcium Exchanger, Time Factors, Ultrasonography
Added February 28, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R
(2013) Nat Genet 45: 1044-9
MeSH Terms: Alleles, Animals, Basic Helix-Loop-Helix Transcription Factors, Brugada Syndrome, Case-Control Studies, Chromosomes, Human, Pair 3, Chromosomes, Human, Pair 6, Death, Sudden, Cardiac, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Male, Mice, Mice, Knockout, NAV1.5 Voltage-Gated Sodium Channel, NAV1.8 Voltage-Gated Sodium Channel, Odds Ratio, Polymorphism, Single Nucleotide, Repressor Proteins, Sodium Channels
Added March 7, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Proliferation of embryonic cardiomyocytes in zebrafish requires the sodium channel scn5Lab.
Bennett JS, Stroud DM, Becker JR, Roden DM
(2013) Genesis 51: 562-74
MeSH Terms: Animals, Cell Differentiation, Cell Proliferation, Heart, Homeobox Protein Nkx-2.5, Morphogenesis, Morpholinos, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Transcription Factors, Zebrafish, Zebrafish Proteins
Added July 21, 2014
1 Communities
1 Members
0 Resources
12 MeSH Terms
NMR studies of the interaction of calmodulin with IQ motif peptides.
Damo SM, Feldkamp MD, Chagot B, Chazin WJ
(2013) Methods Mol Biol 963: 173-86
MeSH Terms: Amino Acid Motifs, Apoproteins, Calcium, Calmodulin, Humans, Intracellular Space, NAV1.5 Voltage-Gated Sodium Channel, Nuclear Magnetic Resonance, Biomolecular, Peptide Fragments, Protein Binding, Signal Transduction
Added March 7, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.
Ritchie MD, Rowan S, Kucera G, Stubblefield T, Blair M, Carter S, Roden DM, Darbar D
(2012) J Am Coll Cardiol 60: 1173-81
MeSH Terms: Adult, Aged, Atrial Fibrillation, Atrial Natriuretic Factor, Chromosomes, Human, Pair 4, Cohort Studies, Genetic Predisposition to Disease, Genotype, Homeobox Protein Nkx-2.5, Homeodomain Proteins, Humans, Ion Channels, KCNQ1 Potassium Channel, Kv1.5 Potassium Channel, Middle Aged, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Pedigree, Polymorphism, Single Nucleotide, Prospective Studies, Registries, Transcription Factors
Added June 26, 2014
0 Communities
1 Members
0 Resources
22 MeSH Terms
Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.
Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM
(2012) Circ Res 111: 322-32
MeSH Terms: Action Potentials, Aniline Compounds, Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cell Line, Transformed, Furans, Humans, Mice, Mice, Knockout, NAV1.5 Voltage-Gated Sodium Channel, NAV1.8 Voltage-Gated Sodium Channel, Rabbits, Rats, Sodium Channel Blockers, Sodium Channels
Added June 26, 2014
0 Communities
2 Members
0 Resources
16 MeSH Terms
Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.
Lowe JS, Stroud DM, Yang T, Hall L, Atack TC, Roden DM
(2012) Cardiovasc Res 95: 300-7
MeSH Terms: Acetanilides, Action Potentials, Animals, Cnidarian Venoms, Disease Models, Animal, Electrocardiography, Female, Genetic Predisposition to Disease, Humans, Long QT Syndrome, Male, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, NAV1.5 Voltage-Gated Sodium Channel, Piperazines, Ranolazine, Risk Factors, Sex Factors, Tachycardia, Ventricular, Time Factors
Added June 26, 2014
0 Communities
2 Members
0 Resources
23 MeSH Terms