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Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy.
Litt MJ, Okoye GD, Lark D, Cakir I, Moore C, Barber MC, Atkinson J, Fessel J, Moslehi J, Cone RD
(2017) Elife 6:
MeSH Terms: Adenosine Diphosphate, Animals, Cardiomyopathy, Dilated, Cell Respiration, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Myocardium, Myocytes, Cardiac, Reactive Oxygen Species, Receptor, Melanocortin, Type 4
Added December 2, 2017
0 Communities
2 Members
0 Resources
11 MeSH Terms
Cardiac repair in a mouse model of acute myocardial infarction with trophoblast stem cells.
Li G, Chen J, Zhang X, He G, Tan W, Wu H, Li R, Chen Y, Gu R, Xie J, Xu B
(2017) Sci Rep 7: 44376
MeSH Terms: Animals, Cardiac Surgical Procedures, Cell Differentiation, Disease Models, Animal, Humans, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Mice, Myocardial Infarction, Myocardium, Myocytes, Cardiac, Trophoblasts
Added September 11, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy.
Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R, He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE, Su YR, Absi T, Kohr MJ, Ziolo MT, Roden DM, Shaffer CM, Galindo CL, Wells QS, Gumina RJ
(2017) Circ Heart Fail 10:
MeSH Terms: Adult, Animals, Calcium Channels, L-Type, Calcium Signaling, Calcium-Binding Proteins, Cardiomyopathies, Case-Control Studies, Disease Models, Animal, Female, Genetic Predisposition to Disease, Humans, Male, Mice, Inbred C57BL, Mice, Knockout, Middle Aged, Myocardial Infarction, Myocardial Reperfusion Injury, Myocardium, Oxidative Stress, Phenotype, Potassium Channels, Inwardly Rectifying, Reactive Nitrogen Species, Reactive Oxygen Species, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Tyrosine, Ventricular Dysfunction, Left, Ventricular Function, Left, Ventricular Pressure
Added April 6, 2017
0 Communities
2 Members
0 Resources
28 MeSH Terms
Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2.
Bylund JB, Trinh LT, Awgulewitsch CP, Paik DT, Jetter C, Jha R, Zhang J, Nolan K, Xu C, Thompson TB, Kamp TJ, Hatzopoulos AK
(2017) Stem Cells Dev 26: 678-693
MeSH Terms: Bone Morphogenetic Proteins, Cell Differentiation, Cell Line, Cell Proliferation, Cells, Cultured, Cytokines, Gene Expression Profiling, Gene Expression Regulation, Developmental, Humans, Induced Pluripotent Stem Cells, Intercellular Signaling Peptides and Proteins, Myocardium, Myocytes, Cardiac, Organogenesis, Signal Transduction, Stem Cells
Added September 6, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Quantitative proteomic changes during post myocardial infarction remodeling reveals altered cardiac metabolism and Desmin aggregation in the infarct region.
Datta K, Basak T, Varshney S, Sengupta S, Sarkar S
(2017) J Proteomics 152: 283-299
MeSH Terms: Cytoskeletal Proteins, Desmin, Heart Failure, Humans, Myocardial Infarction, Myocardium, Oxidative Stress, Proteomics, Spatio-Temporal Analysis, Ventricular Remodeling
Added November 3, 2017
0 Communities
1 Members
0 Resources
10 MeSH Terms
Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart.
Stroud DM, Yang T, Bersell K, Kryshtal DO, Nagao S, Shaffer C, Short L, Hall L, Atack TC, Zhang W, Knollmann BC, Baudenbacher F, Roden DM
(2016) J Am Heart Assoc 5:
MeSH Terms: Action Potentials, Animals, Electrocardiography, Heart, Heart Ventricles, Isolated Heart Preparation, Mice, Mice, Knockout, Myocardium, Myocytes, Cardiac, NAV1.8 Voltage-Gated Sodium Channel, Patch-Clamp Techniques, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction
Added February 3, 2017
1 Communities
2 Members
0 Resources
14 MeSH Terms
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA, Anders RA, Sosman JA, Moslehi JJ
(2016) N Engl J Med 375: 1749-1755
MeSH Terms: Aged, Antibodies, Monoclonal, Arrhythmias, Cardiac, Electrocardiography, Fatal Outcome, Female, Glucocorticoids, Heart Block, Humans, Immunotherapy, Ipilimumab, Male, Melanoma, Middle Aged, Myocarditis, Myocardium, Myositis, Nivolumab
Added March 26, 2017
0 Communities
5 Members
0 Resources
18 MeSH Terms
Transcription factor ETV1 is essential for rapid conduction in the heart.
Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS
(2016) J Clin Invest 126: 4444-4459
MeSH Terms: Animals, DNA-Binding Proteins, Heart Atria, Heart Conduction System, Heart Ventricles, Homeobox Protein Nkx-2.5, Humans, Mice, Mice, Transgenic, Myocardium, Myocytes, Cardiac, NAV1.5 Voltage-Gated Sodium Channel, Transcription Factors
Added March 14, 2018
0 Communities
2 Members
0 Resources
13 MeSH Terms
Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents.
Scarlett JM, Rojas JM, Matsen ME, Kaiyala KJ, Stefanovski D, Bergman RN, Nguyen HT, Dorfman MD, Lantier L, Wasserman DH, Mirzadeh Z, Unterman TG, Morton GJ, Schwartz MW
(2016) Nat Med 22: 800-6
MeSH Terms: Adipose Tissue, Animals, Blood Glucose, Blotting, Western, Body Composition, Brain, Carbon Radioisotopes, Deoxyglucose, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Diet, High-Fat, Disease Models, Animal, Ependymoglial Cells, Fibroblast Growth Factor 1, Forkhead Box Protein O1, Glucose Tolerance Test, Heart, Heat-Shock Proteins, Hyperglycemia, Hypothalamus, Injections, Intraventricular, Liver, Male, Mice, Mice, Knockout, Mice, Obese, Molecular Chaperones, Muscle, Skeletal, Myocardium, Neoplasm Proteins, Proto-Oncogene Proteins c-fos, Rats, Rats, Zucker, Real-Time Polymerase Chain Reaction, Receptor, Insulin, Remission Induction
Added May 16, 2019
0 Communities
1 Members
0 Resources
36 MeSH Terms
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE
(2017) Pharmacogenomics J 17: 137-145
MeSH Terms: Adipose Tissue, Alternative Splicing, Cell Line, Computational Biology, Databases, Genetic, Genotype, High-Throughput Nucleotide Sequencing, Humans, Kidney, Liver, Myocardium, Pharmacogenetics, Pharmacogenomic Variants, Phenotype, Sequence Analysis, RNA, Transcriptome
Added February 22, 2016
0 Communities
2 Members
0 Resources
16 MeSH Terms