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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 21

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Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1.
Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM
(2013) Am J Physiol Gastrointest Liver Physiol 305: G786-96
MeSH Terms: Adenocarcinoma, Animals, Antigens, Bacterial, Apoptosis, Bacterial Proteins, Carcinogenesis, Cell Line, Tumor, Down-Regulation, Female, Gastric Mucosa, Gene Expression Regulation, Neoplastic, Helicobacter pylori, Humans, Mice, MicroRNAs, Middle Aged, Myeloid Cell Leukemia Sequence 1 Protein, Species Specificity, Stomach Neoplasms, Transcription, Genetic
Added March 5, 2014
0 Communities
6 Members
0 Resources
20 MeSH Terms
The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737.
Boiani M, Daniel C, Liu X, Hogarty MD, Marnett LJ
(2013) J Biol Chem 288: 6980-90
MeSH Terms: Adaptor Proteins, Signal Transducing, Antineoplastic Agents, Apoptosis, Apoptosis Regulatory Proteins, Biphenyl Compounds, Cell Line, Tumor, Cell Survival, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Immunoblotting, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasms, Nitrophenols, Piperazines, Proteasome Endopeptidase Complex, Protein Binding, Protein Stability, Proteolysis, Proto-Oncogene Proteins c-bcl-2, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, Sulfonamides, Ubiquitination
Added March 7, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW
(2013) J Med Chem 56: 15-30
MeSH Terms: Antineoplastic Agents, Crystallography, X-Ray, Databases, Factual, Drug Design, Humans, Indoles, Ligands, Magnetic Resonance Spectroscopy, Molecular Docking Simulation, Molecular Structure, Myeloid Cell Leukemia Sequence 1 Protein, Protein Binding, Proto-Oncogene Proteins c-bcl-2, Small Molecule Libraries, Structure-Activity Relationship, bcl-X Protein
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.
Nifoussi SK, Vrana JA, Domina AM, De Biasio A, Gui J, Gregory MA, Hann SR, Craig RW
(2012) PLoS One 7: e47060
MeSH Terms: Animals, Antineoplastic Agents, Apoptosis, Blotting, Western, CHO Cells, Cell Line, Tumor, Cisplatin, Cricetinae, Cytarabine, Drug Resistance, Neoplasm, Etoposide, Flow Cytometry, Glycogen Synthase Kinase 3, Humans, Myeloid Cell Leukemia Sequence 1 Protein, Phosphorylation, Protein Stability, Proto-Oncogene Proteins c-bcl-2, Threonine, Vinblastine
Added March 20, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Notch promotes radioresistance of glioma stem cells.
Wang J, Wakeman TP, Lathia JD, Hjelmeland AB, Wang XF, White RR, Rich JN, Sullenger BA
(2010) Stem Cells 28: 17-28
MeSH Terms: AC133 Antigen, Amyloid Precursor Protein Secretases, Animals, Antigens, CD, Cell Death, Cell Proliferation, Cell Survival, Dose-Response Relationship, Radiation, Enzyme Inhibitors, Glioblastoma, Glycoproteins, Humans, Mice, Mice, Nude, Myeloid Cell Leukemia Sequence 1 Protein, Neoplastic Stem Cells, Peptides, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-bcl-2, RNA Interference, Radiation Tolerance, Radiation-Sensitizing Agents, Receptor, Notch1, Receptor, Notch2, Signal Transduction, Spheroids, Cellular, Time Factors, Transfection, Tumor Burden, Tumor Cells, Cultured, Xenograft Model Antitumor Assays
Added March 5, 2014
0 Communities
1 Members
0 Resources
32 MeSH Terms
HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins.
Jacobs AT, Marnett LJ
(2009) J Biol Chem 284: 9176-83
MeSH Terms: Adaptor Proteins, Signal Transducing, Aldehydes, Apoptosis, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Myeloid Cell Leukemia Sequence 1 Protein, Oligonucleotide Array Sequence Analysis, Protein Binding, Proto-Oncogene Proteins c-bcl-2, RNA, Small Interfering, Transcription Factors
Added March 7, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function.
Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, Opferman JT
(2009) Blood 113: 2805-15
MeSH Terms: Animals, Apoptosis, Apoptosis Regulatory Proteins, Bcl-2-Like Protein 11, Bone Marrow Cells, Escherichia coli, Filgrastim, Gene Deletion, Granulocyte Colony-Stimulating Factor, Granulocytes, Macrophage Activation, Macrophages, Peritoneal, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Cell Leukemia Sequence 1 Protein, Myelopoiesis, Organ Specificity, Phagocytosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Recombinant Proteins, Specific Pathogen-Free Organisms, Tumor Suppressor Proteins, bcl-2 Homologous Antagonist-Killer Protein, bcl-2-Associated X Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
27 MeSH Terms
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.
Tahir SK, Yang X, Anderson MG, Morgan-Lappe SE, Sarthy AV, Chen J, Warner RB, Ng SC, Fesik SW, Elmore SW, Rosenberg SH, Tse C
(2007) Cancer Res 67: 1176-83
MeSH Terms: Antineoplastic Combined Chemotherapy Protocols, Apoptosis, Apoptosis Regulatory Proteins, Bcl-2-Like Protein 11, Biphenyl Compounds, Carboplatin, Carcinoma, Small Cell, Cell Growth Processes, Cell Line, Tumor, Down-Regulation, Drug Synergism, Etoposide, Humans, Lung Neoplasms, Membrane Proteins, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasm Proteins, Nitrophenols, Piperazines, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, RNA, Small Interfering, Sulfonamides, Transfection, Up-Regulation
Added March 5, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.
Lin X, Morgan-Lappe S, Huang X, Li L, Zakula DM, Vernetti LA, Fesik SW, Shen Y
(2007) Oncogene 26: 3972-9
MeSH Terms: 3' Untranslated Regions, Antineoplastic Agents, Base Sequence, Benzenesulfonates, Biphenyl Compounds, Blotting, Western, Carcinoma, Small Cell, Cell Line, Tumor, Cell Survival, DNA-Binding Proteins, Drug Resistance, Neoplasm, Humans, Lung Neoplasms, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasm Proteins, Niacinamide, Nitrophenols, Phenylurea Compounds, Piperazines, Proto-Oncogene Proteins c-bcl-2, Purines, Pyridines, RNA Interference, RNA, Small Interfering, Receptor, Fibroblast Growth Factor, Type 2, Roscovitine, Sorafenib, Sulfonamides, Transmembrane Activator and CAML Interactor Protein, Zinc Fingers, bcl-X Protein
Added March 5, 2014
0 Communities
1 Members
0 Resources
31 MeSH Terms
Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis.
Timofeeva OA, Plisov S, Evseev AA, Peng S, Jose-Kampfner M, Lovvorn HN, Dome JS, Perantoni AO
(2006) Oncogene 25: 7555-64
MeSH Terms: Apoptosis Regulatory Proteins, Casein Kinase II, Cell Line, Cell Line, Tumor, Cell Survival, Child, Green Fluorescent Proteins, HSP27 Heat-Shock Proteins, Heat-Shock Proteins, Humans, Kidney, Kidney Neoplasms, Molecular Chaperones, Myeloid Cell Leukemia Sequence 1 Protein, Neoplasm Proteins, Phosphorylation, Phosphoserine, Proto-Oncogene Proteins c-bcl-2, STAT1 Transcription Factor, Transfection, Wilms Tumor
Added December 26, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms