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Results: 11 to 18 of 18

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Comparative aspects of methemoglobin formation and reduction in opossum (Didelphis virginiana) and human erythrocytes.
Bethlenfalvay NC, Waterman MR, Lima JE, Waldrup T
(1983) Comp Biochem Physiol A Comp Physiol 75: 635-9
MeSH Terms: Animals, Erythrocytes, Glucose, Glutathione, Glycolysis, Hemoglobins, Humans, In Vitro Techniques, Methemoglobinemia, Nitrites, Opossums, Species Specificity
Show Abstract · Added February 12, 2015
Glucose-depleted, nitrite-treated opossum erythrocytes effectively reduce methemoglobin in an environment of physiological saline and added glucose does not accelerate the rate of reduction. In autologous plasma or 25 mM phosphate-buffered saline pH 7.4, added glucose significantly accelerates methemoglobin reduction in glucose-depleted, nitrite-treated opossum erythrocytes. Human red cells require added glucose to carry out reduction of methemoglobin and increased phosphate concentration or autologous plasma does not alter the rate of this process. Within the opossum red cell in vitro, autooxidation of hemoglobin proceeds at a much slower rate than that observed in human erythrocytes.
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12 MeSH Terms
Activity of various metalloporphyrin protein complexes with microsomal heme oxygenase.
Schacter BA, Waterman MR
(1974) Life Sci 14: 47-53
MeSH Terms: Animals, Carbon Monoxide, Cobalt, Copper, Cyanides, Deuterium, Fluorides, Globins, Heme, Hemeproteins, Iron, Ligands, Male, Metalloproteins, Methemoglobin, Microsomes, Microsomes, Liver, Nickel, Oxygenases, Palladium, Porphyrins, Potassium, Rats, Spleen, Structure-Activity Relationship
Added February 12, 2015
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1 Members
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25 MeSH Terms
Effect of ligands on alkaline denaturation of fetal hemoglobin and isolated gamma subunits.
Painter TD, Waterman MR
(1973) Biochem Biophys Res Commun 55: 812-7
MeSH Terms: Carboxyhemoglobin, Chromatography, Ion Exchange, Electrophoresis, Disc, Female, Fetal Hemoglobin, Humans, Hydrogen-Ion Concentration, Iron, Kinetics, Ligands, Mercuribenzoates, Methemoglobin, Peptides, Pregnancy, Protein Denaturation, Spectrophotometry, Time Factors, Umbilical Cord
Added February 12, 2015
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1 Members
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18 MeSH Terms
Phase I clinical study of N-[(4-chlorophenyl)amino]carbonyl-2,3-dihydro-1H-indene-5-sulfonamide (LY186641).
Hainsworth JD, Hande KR, Satterlee WG, Kuttesch J, Johnson DH, Grindey G, Jackson LE, Greco FA
(1989) Cancer Res 49: 5217-20
MeSH Terms: Antineoplastic Agents, Drug Evaluation, Female, Humans, Male, Methemoglobinemia, Middle Aged, Neoplasms, Sulfonylurea Compounds, Time Factors
Show Abstract · Added March 5, 2014
Between February 1987 and July 1988, 45 patients with advanced refractory cancer were treated with LY186641, a diarylsulfonylurea that has shown a broad spectrum of activity in preclinical testing. Patients received a weekly p.o. dose of LY186641 for 6 consecutive weeks; responding and stable patients continued weekly therapy until progression occurred. Using a standard phase I study design, the first three patients received LY186641 at 30 mg/m2 week; the dose was escalated in subsequent patients until dose-limiting toxicity occurred. Methemoglobinemia was the major toxicity observed and was dose related. Methemoglobin levels peaked approximately 24 h after LY186641 was administered and fell to low levels after 48 h. Six patients developed fatigue, cyanosis, and dyspnea associated with serum methemoglobinemia levels of greater than 20%; four of these patients were subsequently removed from the study. Hemolytic anemia was also observed but was clinically significant in only 10 patients. Other side effects were mild and infrequent. The maximum tolerated dose of LY186641, when given at this schedule, was 2550 mg/m2/week. No objective tumor responses were observed.
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10 MeSH Terms
Kinetics of N-[(4-chlorophenyl)amino]carbonyl-2,3-dihydro-1H-indene-5-sulfonamide (LY186641) in humans.
Hande KR, Kuttesch J, Hamilton M, Satterlee W, Jackson L, Grindey G, Hainsworth JD
(1990) Cancer Res 50: 3910-4
MeSH Terms: Administration, Oral, Half-Life, Humans, Methemoglobinemia, Neoplasms, Sulfonylurea Compounds, Time Factors
Show Abstract · Added March 5, 2014
The metabolism and disposition of LY186641, a diarylsulfonylurea with antineoplastic activity identified in preclinical tests, was determined in 21 patients who received 23 courses of orally administered drug. A linear correlation was found between the dose of drug administered and LY186641 peak plasma concentrations and LY186641 area under the curve measurements. Clearance (135 +/- 36 ml/h/m2), terminal half-life (31 +/- 11 h), and volume of distribution (10.2 +/- 2.8 liters) were independent of drug dose. No LY186641 was excreted in urine. Hydroxy and keto metabolites of LY186641 were identified in plasma and urine samples. Urinary excretion of these metabolites during the initial 48 h following drug administration accounted for 20% of LY186641 disposition. Plasma half-life of the hydroxy and keto metabolites was longer than that of parent drug (3.3 and 3.1 days, respectively). Plasma concentrations of parent drug correlated with the presence of methemoglobinemia, the dose-limiting toxicity found with LY186641.
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7 MeSH Terms
Spectral characterization of human hemoglobin and its derivatives.
Waterman MR
(1978) Methods Enzymol 52: 456-63
MeSH Terms: Hemoglobins, Humans, Methemoglobin, Oxyhemoglobins, Spectrophotometry
Added February 12, 2015
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5 MeSH Terms
Methemoglobinemia from sniffing butyl nitrite.
Horne MK, Waterman MR, Simon LM, Garriott JC, Foerster EH
(1979) Ann Intern Med 91: 417-8
MeSH Terms: Adult, Cytochrome-B(5) Reductase, Half-Life, Humans, Kinetics, Male, Methemoglobinemia, NADH, NADPH Oxidoreductases, Nitrites, Substance-Related Disorders
Added February 12, 2015
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10 MeSH Terms
Differential effects of pH and inositol hexaphosphate on the spectroscopic properties of the alpha and beta subunits in methemoglobins M Milwaukee and A.
John ME, Waterman MR
(1979) Biochim Biophys Acta 578: 269-80
MeSH Terms: Chemical Phenomena, Chemistry, Electron Spin Resonance Spectroscopy, Humans, Hydrogen-Ion Concentration, Methemoglobin, Phytic Acid, Protein Binding, Spectrophotometry
Show Abstract · Added February 12, 2015
The effect of pH and inositol hexaphosphate on the electron spin resonance spectra of the alpha-hemes (g = 6.0) and the beta-hemes (g = 6.7) has been measured in methemoglobin M Milwaukee and compared with that of methemoglobin A (g = 6.0). The beta-hemes are found to be comparatively insensitive to both effectors while the alpha-hemes behave in a manner similar to the heme groups of methemoglobin A. Binding of inositol hexaphosphate enhances the high spin ESR signal of the alpha-hemes in both methemoglobins. Comparison of the optical properties of methemoglobins A and M Milwaukee over the pH range from 5.0 to 8.1 shows that inositol hexaphosphate has a differential effect on the subunit types in these two methemoglobins. At low pH the spectral changes observed upon inositol hexaphosphate binding arise primarily from the beta-hemes, while at neutral and alkaline pH these changes arise from both subunit types. The beta-heme spectral changes appear to be pH independent while those arising from the alpha-hemes are strongly pH dependent. It is concluded that it is the hydroxymet form of the alpha-hemes which undergoes spectral change upon inositol hexaphosphate binding to the beta-subunits. In methemoglobin A the spin state and paramagnetic susceptibility increase only in the neutral and alkaline pH ranges upon inositol hexaphosphate binding (Gupta, R.K. and Mildvan, R.S. (1975) J. Biol. Chem. 250, 246; Perutz, M.F., Sanders, J.K.M., Chenery, D.H., Noble, R.W., Penelly, R.R., Fung, L.W.-M., Ho, C., Giannini, I., Porschke, D. and Winkler, H. (1978) Biochemistry 17, 3640). Therefore the hydroxymet form of the alpha-hemes which is responsible for the observed spectral changes must also be responsible for these increases in the magnetic properties of methemoglobin A. Inositol hexaphosphate can bind to methemoglobin at alkaline pH if the beta-hemes are in the high spin form.
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9 MeSH Terms