Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 11 to 20 of 155

Publication Record

Connections

Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.
Sengmany K, Singh J, Stewart GD, Conn PJ, Christopoulos A, Gregory KJ
(2017) Neuropharmacology 115: 60-72
MeSH Terms: Allosteric Regulation, Animals, Calcium Signaling, Dose-Response Relationship, Drug, Drug Discovery, Drug Evaluation, Preclinical, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, Female, HEK293 Cells, Humans, MAP Kinase Signaling System, Mice, Receptor, Metabotropic Glutamate 5
Added April 6, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
Laminin-111 peptide C16 regulates invadopodia activity of malignant cells through β1 integrin, Src and ERK 1/2.
Siqueira AS, Pinto MP, Cruz MC, Smuczek B, Cruz KS, Barbuto JA, Hoshino D, Weaver AM, Freitas VM, Jaeger RG
(2016) Oncotarget 7: 47904-47917
MeSH Terms: Carcinoma, Squamous Cell, Cell Line, Tumor, Fibrosarcoma, Head and Neck Neoplasms, Humans, Integrin beta1, Laminin, MAP Kinase Signaling System, Mouth Neoplasms, Peptide Fragments, Podosomes, Squamous Cell Carcinoma of Head and Neck, Transfection, src-Family Kinases
Added April 26, 2017
0 Communities
1 Members
0 Resources
14 MeSH Terms
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.
Gupta A, Gomes I, Bobeck EN, Fakira AK, Massaro NP, Sharma I, Cavé A, Hamm HE, Parello J, Devi LA
(2016) Proc Natl Acad Sci U S A 113: 6041-6
MeSH Terms: Agaricales, Animals, Antipruritics, Diterpenes, Clerodane, HEK293 Cells, Humans, MAP Kinase Signaling System, Mice, Mice, Knockout, Receptors, Opioid, kappa, Second Messenger Systems
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.
Puvirajesinghe TM, Bertucci F, Jain A, Scerbo P, Belotti E, Audebert S, Sebbagh M, Lopez M, Brech A, Finetti P, Charafe-Jauffret E, Chaffanet M, Castellano R, Restouin A, Marchetto S, Collette Y, Gonçalvès A, Macara I, Birnbaum D, Kodjabachian L, Johansen T, Borg JP
(2016) Nat Commun 7: 10318
MeSH Terms: Adaptor Proteins, Signal Transducing, Animals, Blotting, Western, Breast Neoplasms, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Cell Line, Tumor, Cell Migration Assays, Cell Movement, Cell Polarity, Cell Proliferation, DNA Copy Number Variations, Embryo, Nonmammalian, Female, Humans, Immunoprecipitation, Intracellular Signaling Peptides and Proteins, MAP Kinase Signaling System, Mass Spectrometry, Membrane Proteins, Mice, Microscopy, Electron, Middle Aged, Neoplasm Transplantation, Prognosis, Proportional Hazards Models, RNA, Messenger, Sequestosome-1 Protein, Wnt Signaling Pathway, Xenopus
Added April 10, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer.
Edmonds MD, Boyd KL, Moyo T, Mitra R, Duszynski R, Arrate MP, Chen X, Zhao Z, Blackwell TS, Andl T, Eischen CM
(2016) J Clin Invest 126: 349-64
MeSH Terms: Adenocarcinoma, Adenocarcinoma of Lung, Animals, Cell Line, Tumor, Female, Humans, Lung Neoplasms, MAP Kinase Signaling System, Male, Mice, MicroRNAs, Mutation, NIH 3T3 Cells, Proto-Oncogene Proteins p21(ras), ras Proteins
Added February 22, 2016
1 Communities
1 Members
0 Resources
15 MeSH Terms
Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo.
Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS
(2015) Mol Syst Biol 11: 835
MeSH Terms: Apoptosis, Enzyme Activation, Epithelial Cells, Humans, MAP Kinase Signaling System, Signal Transduction, Single-Cell Analysis, Tumor Necrosis Factor-alpha
Added November 1, 2015
4 Communities
5 Members
0 Resources
8 MeSH Terms
VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy.
Nickols HH, Yuh JP, Gregory KJ, Morrison RD, Bates BS, Stauffer SR, Emmitte KA, Bubser M, Peng W, Nedelcovych MT, Thompson A, Lv X, Xiang Z, Daniels JS, Niswender CM, Lindsley CW, Jones CK, Conn PJ
(2016) J Pharmacol Exp Ther 356: 123-36
MeSH Terms: Allosteric Regulation, Animals, Anti-Anxiety Agents, Astrocytes, Behavior, Animal, Brain, Dose-Response Relationship, Drug, Drug Discovery, GABA Agonists, HEK293 Cells, Humans, Inositol Phosphates, MAP Kinase Signaling System, Membrane Potentials, Mice, Mice, Inbred C57BL, Picolinic Acids, Pyridines, Radioligand Assay, Rats, Receptor, Metabotropic Glutamate 5, Synaptic Transmission
Added February 18, 2016
0 Communities
3 Members
0 Resources
22 MeSH Terms
Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair.
Sato N, Ichikawa J, Wako M, Ohba T, Saito M, Sato H, Koyama K, Hagino T, Schoenecker JG, Ando T, Haro H
(2016) Bone 83: 23-34
MeSH Terms: Animals, Cell Movement, Chemokine CCL2, Disease Models, Animal, Fracture Healing, Humans, Inflammation, Interleukin-6, MAP Kinase Signaling System, Male, Mice, Mice, Inbred C57BL, Models, Biological, Osteoblasts, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, RAW 264.7 Cells, Receptor, PAR-1, Thrombin, Thromboplastin
Added February 22, 2016
0 Communities
1 Members
0 Resources
20 MeSH Terms
Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons.
Cohen MR, Johnson WM, Pilat JM, Kiselar J, DeFrancesco-Lisowitz A, Zigmond RE, Moiseenkova-Bell VY
(2015) Mol Cell Biol 35: 4238-52
MeSH Terms: Animals, Calcium, Calcium Channels, Cell Line, Tumor, Extracellular Signal-Regulated MAP Kinases, HEK293 Cells, Humans, MAP Kinase Signaling System, Nerve Growth Factor, Neurites, Neurogenesis, Neurons, PC12 Cells, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, RNA Interference, RNA, Small Interfering, Rats, Receptor, trkA, TRPV Cation Channels, rab GTP-Binding Proteins
Added April 24, 2017
0 Communities
1 Members
0 Resources
21 MeSH Terms
Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis.
Chang J, Vacher J, Yao B, Fan X, Zhang B, Harris RC, Zhang MZ
(2015) Oncotarget 6: 33500-11
MeSH Terms: Animals, Carcinogenesis, Colorectal Neoplasms, Cyclooxygenase 2, Disease Models, Animal, Female, MAP Kinase Signaling System, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Myeloid Cells, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, RAW 264.7 Cells, Receptors, Prostaglandin E, EP4 Subtype, TOR Serine-Threonine Kinases
Added May 5, 2017
1 Communities
0 Members
0 Resources
17 MeSH Terms