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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 32

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The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.
Coffa S, Breitman M, Hanson SM, Callaway K, Kook S, Dalby KN, Gurevich VV
(2011) PLoS One 6: e28723
MeSH Terms: Animals, Arrestin, Arrestins, COS Cells, Cattle, Chlorocebus aethiops, Embryo, Mammalian, Enzyme Activation, Fibroblasts, HEK293 Cells, Humans, Ligands, MAP Kinase Kinase 1, Mice, Mice, Knockout, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mutant Proteins, Phosphorylation, Protein Binding, Protein Conformation, Proto-Oncogene Proteins c-raf, Receptors, Adrenergic, beta-2, Structure-Activity Relationship, beta-Arrestins
Added December 10, 2013
0 Communities
1 Members
0 Resources
25 MeSH Terms
Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.
Kirkwood JM, Bastholt L, Robert C, Sosman J, Larkin J, Hersey P, Middleton M, Cantarini M, Zazulina V, Kemsley K, Dummer R
(2012) Clin Cancer Res 18: 555-67
MeSH Terms: Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Alkylating, Benzimidazoles, DNA Mutational Analysis, Dacarbazine, Disease-Free Survival, Drug Substitution, Female, Humans, Kaplan-Meier Estimate, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Male, Melanoma, Middle Aged, Mutation, Neoplasm Staging, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), Temozolomide, Treatment Outcome, Young Adult
Added March 20, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex.
Zhan X, Kaoud TS, Dalby KN, Gurevich VV
(2011) Biochemistry 50: 10520-9
MeSH Terms: Animals, Arrestins, Cattle, Cells, Cultured, Humans, MAP Kinase Kinase 1, MAP Kinase Kinase 4, MAP Kinase Signaling System, Mitogen-Activated Protein Kinase 10, Phosphorylation, Protein Binding, Up-Regulation, beta-Arrestins
Added December 10, 2013
0 Communities
1 Members
0 Resources
13 MeSH Terms
Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells.
Bose D, Zimmerman LJ, Pierobon M, Petricoin E, Tozzi F, Parikh A, Fan F, Dallas N, Xia L, Gaur P, Samuel S, Liebler DC, Ellis LM
(2011) Br J Cancer 105: 1759-67
MeSH Terms: Animals, Antineoplastic Agents, Bystander Effect, Cell Line, Tumor, Cell Survival, Colorectal Neoplasms, Culture Media, Drug Resistance, Neoplasm, ErbB Receptors, HCT116 Cells, HT29 Cells, Humans, Intercellular Signaling Peptides and Proteins, MAP Kinase Kinase 1, Male, Mass Spectrometry, Mice, Mice, Nude, Microarray Analysis, Neoplastic Stem Cells, Organoplatinum Compounds, Oxaliplatin, Phosphorylation, Progranulins, Proto-Oncogene Proteins c-akt, Signal Transduction, Up-Regulation
Added March 20, 2014
0 Communities
1 Members
0 Resources
27 MeSH Terms
Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers.
Bekaii-Saab T, Phelps MA, Li X, Saji M, Goff L, Kauh JS, O'Neil BH, Balsom S, Balint C, Liersemann R, Vasko VV, Bloomston M, Marsh W, Doyle LA, Ellison G, Grever M, Ringel MD, Villalona-Calero MA
(2011) J Clin Oncol 29: 2357-63
MeSH Terms: Adult, Aged, Benzimidazoles, Biliary Tract Neoplasms, Extracellular Signal-Regulated MAP Kinases, Female, Humans, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Male, Middle Aged, Mutation, Neoplasm Metastasis, Phosphorylation, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins p21(ras), ras Proteins
Added March 11, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma.
O'Neil BH, Goff LW, Kauh JS, Strosberg JR, Bekaii-Saab TS, Lee RM, Kazi A, Moore DT, Learoyd M, Lush RM, Sebti SM, Sullivan DM
(2011) J Clin Oncol 29: 2350-6
MeSH Terms: Aged, Benzimidazoles, Carcinoma, Hepatocellular, Female, Humans, Liver Neoplasms, MAP Kinase Kinase 1, MAP Kinase Kinase 2, Male, Middle Aged
Added March 11, 2014
0 Communities
1 Members
0 Resources
10 MeSH Terms
KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1.
Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB
(2011) Exp Cell Res 317: 452-63
MeSH Terms: Animals, Apoptosis, Catalysis, Colon, Epithelial Cells, Escherichia coli Proteins, MAP Kinase Kinase 1, Mice, Phosphorylation, Protein Kinases, Serine, Substrate Specificity, Tumor Necrosis Factor-alpha
Added March 5, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
Inhibition of PI3K and MEK: it is all about combinations and biomarkers.
Rexer BN, Ghosh R, Arteaga CL
(2009) Clin Cancer Res 15: 4518-20
MeSH Terms: Animals, Antineoplastic Agents, Biomarkers, Tumor, Breast Neoplasms, Cell Line, Tumor, Enzyme Inhibitors, Female, Humans, MAP Kinase Kinase 1, Mammary Neoplasms, Experimental, Mice, Mice, Inbred Strains, Mice, Nude, Models, Biological, Phosphatidylinositol 3-Kinases, Phosphoinositide-3 Kinase Inhibitors, Xenograft Model Antitumor Assays
Added March 10, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma.
Marks JL, Gong Y, Chitale D, Golas B, McLellan MD, Kasai Y, Ding L, Mardis ER, Wilson RK, Solit D, Levine R, Michel K, Thomas RK, Rusch VW, Ladanyi M, Pao W
(2008) Cancer Res 68: 5524-8
MeSH Terms: Adenocarcinoma, Amino Acid Sequence, Animals, DNA Mutational Analysis, ErbB Receptors, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms, MAP Kinase Kinase 1, Mice, Molecular Sequence Data, Mutation, Sequence Homology, Amino Acid, Signal Transduction
Added March 24, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
15(S)-HETE production in human retinal microvascular endothelial cells by hypoxia: Novel role for MEK1 in 15(S)-HETE induced angiogenesis.
Bajpai AK, Blaskova E, Pakala SB, Zhao T, Glasgow WC, Penn JS, Johnson DA, Rao GN
(2007) Invest Ophthalmol Vis Sci 48: 4930-8
MeSH Terms: Adenoviridae, Arachidonate 15-Lipoxygenase, Basement Membrane, Cell Movement, Cells, Cultured, Chromatography, High Pressure Liquid, Endothelium, Vascular, Enzyme Inhibitors, Genetic Vectors, Humans, Hydroxyeicosatetraenoic Acids, Hypoxia, MAP Kinase Kinase 1, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinase 8, Phosphorylation, Retinal Neovascularization, Retinal Vessels, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, p38 Mitogen-Activated Protein Kinases
Added October 9, 2013
1 Communities
1 Members
0 Resources
22 MeSH Terms