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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 60

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Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing.
Giudicessi JR, Roden DM, Wilde AAM, Ackerman MJ
(2018) Circulation 137: 619-630
MeSH Terms: Action Potentials, Diagnostic Errors, Genetic Predisposition to Disease, Genetic Testing, Genetic Variation, Heart Conduction System, Heart Rate, Humans, Long QT Syndrome, NAV1.5 Voltage-Gated Sodium Channel, Phenotype, Potassium Channels, Voltage-Gated, Predictive Value of Tests, Prognosis, Reproducibility of Results, Risk Assessment, Risk Factors
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Exploiting ion channel structure to assess rare variant pathogenicity.
Kroncke BM, Yang T, Kannankeril P, Shoemaker MB, Roden DM
(2018) Heart Rhythm 15: 890-894
MeSH Terms: Adolescent, Adult, Body Surface Potential Mapping, DNA, DNA Mutational Analysis, ERG1 Potassium Channel, Female, Humans, KCNQ1 Potassium Channel, Long QT Syndrome, Mutation, Pedigree, Phenotype
Added March 26, 2019
0 Communities
3 Members
0 Resources
MeSH Terms
Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance.
Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL, Sanders CR, Meiler J
(2017) Circ Cardiovasc Genet 10:
MeSH Terms: Databases, Genetic, Female, Genetic Variation, Humans, KCNQ1 Potassium Channel, Long QT Syndrome, Male, Predictive Value of Tests, Protein Domains
Added March 14, 2018
0 Communities
4 Members
0 Resources
9 MeSH Terms
Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.
Strauss DG, Vicente J, Johannesen L, Blinova K, Mason JW, Weeke P, Behr ER, Roden DM, Woosley R, Kosova G, Rosenberg MA, Newton-Cheh C
(2017) Circulation 135: 1300-1310
MeSH Terms: Adult, Arrhythmias, Cardiac, Female, Genome-Wide Association Study, Humans, Long QT Syndrome, Male, Pilot Projects, Polymorphism, Single Nucleotide, Risk Assessment, Torsades de Pointes
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Regulation of KCNQ/Kv7 family voltage-gated K channels by lipids.
Taylor KC, Sanders CR
(2017) Biochim Biophys Acta Biomembr 1859: 586-597
MeSH Terms: Amino Acid Sequence, Binding Sites, Cell Membrane, Epilepsy, Benign Neonatal, Fatty Acids, Unsaturated, Hearing Loss, Bilateral, Humans, Hydrophobic and Hydrophilic Interactions, KCNQ1 Potassium Channel, Long QT Syndrome, Membrane Lipids, Models, Molecular, Phosphatidylinositol 4,5-Diphosphate, Protein Binding, Protein Isoforms, Protein Structure, Secondary
Added November 21, 2018
0 Communities
1 Members
0 Resources
MeSH Terms
Finding a Needle in a QT Interval Big Data Haystack: The Role for Orthogonal Datasets.
Roden DM, Mosley JD, Denny JC
(2016) J Am Coll Cardiol 68: 1765-1768
MeSH Terms: Ether-A-Go-Go Potassium Channels, Humans, Long QT Syndrome, Potassium Channels, Voltage-Gated, Torsades de Pointes
Added March 14, 2018
0 Communities
2 Members
0 Resources
5 MeSH Terms
Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC
(2016) Circ Arrhythm Electrophysiol 9:
MeSH Terms: Action Potentials, Adult, Animals, Calmodulin, DNA Mutational Analysis, Electrocardiography, Exercise Test, Female, Genotype, Humans, Long QT Syndrome, Male, Mice, Phenotype, Ryanodine, Tachycardia, Ventricular
Added April 18, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes.
Pipilas DC, Johnson CN, Webster G, Schlaepfer J, Fellmann F, Sekarski N, Wren LM, Ogorodnik KV, Chazin DM, Chazin WJ, Crotti L, Bhuiyan ZA, George AL
(2016) Heart Rhythm 13: 2012-9
MeSH Terms: Action Potentials, Calmodulin, Child, Preschool, Electrocardiography, Genetic Predisposition to Disease, Humans, Infant, Long QT Syndrome, Male, Mutation, Myocytes, Cardiac, Switzerland
Added April 18, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.
Boczek NJ, Gomez-Hurtado N, Ye D, Calvert ML, Tester DJ, Kryshtal D, Hwang HS, Johnson CN, Chazin WJ, Loporcaro CG, Shah M, Papez AL, Lau YR, Kanter R, Knollmann BC, Ackerman MJ
(2016) Circ Cardiovasc Genet 9: 136-146
MeSH Terms: Amino Acid Sequence, Animals, Calmodulin, Demography, Female, Humans, Long QT Syndrome, Male, Mice, Inbred C57BL, Mutation, Missense, Prevalence, Young Adult
Added April 18, 2017
0 Communities
1 Members
0 Resources
12 MeSH Terms
Predicting drug-induced QT prolongation and torsades de pointes.
Roden DM
(2016) J Physiol 594: 2459-68
MeSH Terms: Animals, Drug-Related Side Effects and Adverse Reactions, Humans, Long QT Syndrome, Myocytes, Cardiac, Torsades de Pointes
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms