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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 112

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Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.
Choi JY, Patra A, Yeom M, Lee YS, Zhang Q, Egli M, Guengerich FP
(2016) J Biol Chem 291: 21063-21073
MeSH Terms: Amino Acid Substitution, Crystallography, X-Ray, DNA-Directed DNA Polymerase, Deoxycytosine Nucleotides, Humans, Hydrogen Bonding, Kinetics, Magnesium, Manganese, Mutation, Missense, Protein Domains
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.
Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI
(2016) J Lipid Res 57: 1552-63
MeSH Terms: 14-alpha Demethylase Inhibitors, Antifungal Agents, Antineoplastic Agents, Antiprotozoal Agents, Catalytic Domain, Cell Line, Tumor, Cholestadienols, Crystallography, X-Ray, Drug Design, Drug Screening Assays, Antitumor, Humans, Hydrogen Bonding, Lanosterol, Models, Molecular, Protein Binding, Protein Conformation, alpha-Helical, Sterol 14-Demethylase
Added April 6, 2017
0 Communities
4 Members
0 Resources
17 MeSH Terms
Origin and prediction of free-solution interaction studies performed label-free.
Bornhop DJ, Kammer MN, Kussrow A, Flowers RA, Meiler J
(2016) Proc Natl Acad Sci U S A 113: E1595-604
MeSH Terms: Hydrogen Bonding, Interferometry, Models, Chemical, Protein Binding, Protein Conformation, Protein Folding, Refractometry, Sensitivity and Specificity, Solutions, Solvents, Water
Added April 8, 2017
1 Communities
1 Members
0 Resources
11 MeSH Terms
Structural and kinetic analysis of nucleoside triphosphate incorporation opposite an abasic site by human translesion DNA polymerase η.
Patra A, Zhang Q, Lei L, Su Y, Egli M, Guengerich FP
(2015) J Biol Chem 290: 8028-38
MeSH Terms: Apurinic Acid, Catalytic Domain, Crystallography, X-Ray, DNA-Directed DNA Polymerase, Deoxyadenine Nucleotides, Humans, Hydrogen Bonding, Kinetics, Models, Molecular, Protein Binding, Tandem Mass Spectrometry
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Dynamics of CYP51: implications for function and inhibitor design.
Yu X, Cojocaru V, Mustafa G, Salo-Ahen OM, Lepesheva GI, Wade RC
(2015) J Mol Recognit 28: 59-73
MeSH Terms: Catalytic Domain, Crystallography, X-Ray, Cytochrome P-450 CYP2C9, Drug Design, Humans, Hydrogen Bonding, Molecular Dynamics Simulation, Protein Structure, Secondary, Protozoan Proteins, Solvents, Sterol 14-Demethylase, Substrate Specificity, Trypanosoma brucei brucei
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Inhibitory effects of a novel Val to Thr mutation on the distal heme of human catalase.
Mashhadi Z, Boeglin WE, Brash AR
(2014) Biochimie 106: 180-3
MeSH Terms: Amino Acid Sequence, Biocatalysis, Catalase, Catalytic Domain, Crystallography, X-Ray, Heme, Humans, Hydrogen Bonding, Hydrogen Peroxide, Models, Molecular, Molecular Structure, Mutant Proteins, Mutation, Missense, Peroxides, Protein Structure, Tertiary, Sequence Homology, Amino Acid, Threonine, Valine
Added January 21, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
In silico analysis and experimental verification of OSR1 kinase - Peptide interaction.
Austin TM, Nannemann DP, Deluca SL, Meiler J, Delpire E
(2014) J Struct Biol 187: 58-65
MeSH Terms: Amino Acid Sequence, Animals, Computer Simulation, Crystallography, X-Ray, Gene Expression, Humans, Hydrogen Bonding, Hydrophobic and Hydrophilic Interactions, Mice, Models, Molecular, Molecular Sequence Data, Mutation, Protein Binding, Protein Interaction Domains and Motifs, Protein Serine-Threonine Kinases, Protein Structure, Secondary, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Two-Hybrid System Techniques
Added January 24, 2015
1 Communities
1 Members
0 Resources
19 MeSH Terms
Stretchable gas barrier achieved with partially hydrogen-bonded multilayer nanocoating.
Holder KM, Spears BR, Huff ME, Priolo MA, Harth E, Grunlan JC
(2014) Macromol Rapid Commun 35: 960-4
MeSH Terms: Bentonite, Gases, Hydrogen Bonding, Nanostructures, Oxygen, Polyethyleneimine, Propylene Glycols, Surface Properties
Added February 15, 2016
0 Communities
1 Members
0 Resources
8 MeSH Terms
Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.
Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ
(2014) J Biol Chem 289: 6799-6808
MeSH Terms: Amino Acid Substitution, Animals, Anti-Inflammatory Agents, Non-Steroidal, Arginine, Binding Sites, Catalytic Domain, Cyclooxygenase 1, Cyclooxygenase 2, Cyclooxygenase Inhibitors, Hydrogen Bonding, Leucine, Meloxicam, Mice, Mutation, Piroxicam, Protein Structure, Secondary, Serine, Thiazines, Thiazoles, Tyrosine, Water
Added March 27, 2014
0 Communities
2 Members
0 Resources
21 MeSH Terms
A single-amino-acid polymorphism in Chikungunya virus E2 glycoprotein influences glycosaminoglycan utilization.
Silva LA, Khomandiak S, Ashbrook AW, Weller R, Heise MT, Morrison TE, Dermody TS
(2014) J Virol 88: 2385-97
MeSH Terms: Alphavirus Infections, Amino Acid Substitution, Animals, CHO Cells, Chikungunya Fever, Chikungunya virus, Chlorocebus aethiops, Cricetinae, Cricetulus, Endosomes, Genotype, Glycosaminoglycans, Heparitin Sulfate, Humans, Hydrogen Bonding, Kinetics, Models, Molecular, Mutation, Polymorphism, Single Nucleotide, Protein Multimerization, Static Electricity, Vero Cells, Viral Envelope Proteins, Virus Attachment, Virus Internalization, Virus Replication
Added May 20, 2014
0 Communities
1 Members
0 Resources
26 MeSH Terms