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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 20

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A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease.
Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB
(2015) Hum Mol Genet 24: 1929-44
MeSH Terms: Amino Acid Motifs, Animals, Ataxia Telangiectasia Mutated Proteins, Cell Line, Corpus Striatum, DNA Damage, Disease Models, Animal, Female, Humans, Huntington Disease, Male, Manganese, Mice, Neural Stem Cells, Phosphorylation, Signal Transduction, Tumor Suppressor Protein p53
Added February 3, 2015
1 Communities
3 Members
0 Resources
17 MeSH Terms
Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism.
Madison JL, Wegrzynowicz M, Aschner M, Bowman AB
(2012) PLoS One 7: e31024
MeSH Terms: Animals, Dendrites, Dopamine, Environmental Exposure, Genotype, Huntington Disease, Male, Manganese, Mice, Mice, Inbred C57BL, Mice, Transgenic, Multivariate Analysis, Neostriatum, Neurons
Added May 19, 2014
1 Communities
1 Members
0 Resources
14 MeSH Terms
Genetic modifiers of neurological disease.
Kearney JA
(2011) Curr Opin Genet Dev 21: 349-53
MeSH Terms: Animals, Carrier Proteins, Charcot-Marie-Tooth Disease, Disease Models, Animal, Humans, Huntington Disease, Mice, Nervous System Diseases, Phenotype, RNA Splicing Factors, Rett Syndrome, Spinocerebellar Ataxias
Added May 27, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation.
Kwakye GF, Li D, Bowman AB
(2011) Neurotoxicology 32: 630-9
MeSH Terms: Animals, Cell Line, Corpus Striatum, Fura-2, High-Throughput Screening Assays, Huntington Disease, Manganese, Mice, Mice, Mutant Strains, Mutation
Added February 3, 2011
1 Communities
1 Members
0 Resources
10 MeSH Terms
Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.
Williams BB, Kwakye GF, Wegrzynowicz M, Li D, Aschner M, Erikson KM, Bowman AB
(2010) Toxicol Sci 117: 169-79
MeSH Terms: Animals, Biological Transport, Cation Transport Proteins, Corpus Striatum, Disease Models, Animal, Homeostasis, Humans, Huntingtin Protein, Huntington Disease, Iron, Manganese, Mice, Nerve Tissue Proteins, Nuclear Proteins
Added February 3, 2011
1 Communities
1 Members
0 Resources
14 MeSH Terms
Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure.
Williams BB, Li D, Wegrzynowicz M, Vadodaria BK, Anderson JG, Kwakye GF, Aschner M, Erikson KM, Bowman AB
(2010) J Neurochem 112: 227-37
MeSH Terms: Animals, Cattle, Cell Line, Cell Survival, Drug Evaluation, Preclinical, Humans, Huntingtin Protein, Huntington Disease, Manganese, Mice, Mice, Transgenic, Nerve Tissue Proteins, Nuclear Proteins
Added June 9, 2010
1 Communities
1 Members
0 Resources
13 MeSH Terms
Genetic testing of children and adolescents: ethical, legal and psychosocial implications.
Martinez W
(1998) Princet J Bioeth 1: 65-75
MeSH Terms: Adolescent, Adoption, Child, Decision Making, Disclosure, Genetic Counseling, Genetic Testing, Heterozygote, Humans, Huntington Disease, Informed Consent, Jurisprudence, Mental Competency, Parent-Child Relations, Parental Consent, Parents, Prejudice, Reproduction, Risk, Risk Assessment, Self Concept, Stress, Psychological, Third-Party Consent
Added May 26, 2017
0 Communities
1 Members
0 Resources
23 MeSH Terms
No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls.
Montine TJ, Shinobu L, Montine KS, Roberts LJ, Kowall NW, Beal MF, Morrow JD
(2000) Ann Neurol 48: 950
MeSH Terms: Aged, Alzheimer Disease, Dinoprost, Humans, Huntington Disease, Middle Aged
Added December 10, 2013
0 Communities
1 Members
0 Resources
6 MeSH Terms
Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease.
Montine TJ, Beal MF, Robertson D, Cudkowicz ME, Biaggioni I, O'Donnell H, Zackert WE, Roberts LJ, Morrow JD
(1999) Neurology 52: 1104-5
MeSH Terms: Adult, Aged, Dinoprost, Female, Humans, Huntington Disease, Male, Middle Aged
Added December 10, 2013
0 Communities
3 Members
0 Resources
8 MeSH Terms
CAG trinucleotide RNA repeats interact with RNA-binding proteins.
McLaughlin BA, Spencer C, Eberwine J
(1996) Am J Hum Genet 59: 561-9
MeSH Terms: Aged, Aged, 80 and over, Animals, Base Sequence, Cell Extracts, Cerebral Cortex, Corpus Striatum, Cross-Linking Reagents, Cytoplasm, Female, Humans, Huntington Disease, Molecular Sequence Data, Molecular Weight, Organ Specificity, RNA Probes, RNA, Messenger, RNA-Binding Proteins, Rats, Trinucleotide Repeats, Ultraviolet Rays
Added January 26, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms