Other search tools

About this data

The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

If you have any questions or comments, please contact us.

Results: 11 to 11 of 11

Publication Record


Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).
Peyssonnaux C, Zinkernagel AS, Schuepbach RA, Rankin E, Vaulont S, Haase VH, Nizet V, Johnson RS
(2007) J Clin Invest 117: 1926-32
MeSH Terms: Albumins, Animals, Antimicrobial Cationic Peptides, Base Sequence, Cation Transport Proteins, Down-Regulation, Gene Deletion, Hepatocytes, Hepcidins, Homeostasis, Humans, Hypoxia-Inducible Factor 1, Integrases, Iron, Liver, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Polycythemia, Promoter Regions, Genetic, Protein Binding, Up-Regulation, Von Hippel-Lindau Tumor Suppressor Protein
Show Abstract · Added August 19, 2013
Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron absorption and homeostasis in mammals. Hepcidin production is increased by iron overload and decreased by anemia and hypoxia; but the molecular mechanisms that govern the hepcidin response to these stimuli are not known. Here we establish that the von Hippel-Lindau/hypoxia-inducible transcription factor (VHL/HIF) pathway is an essential link between iron homeostasis and hepcidin regulation in vivo. Through coordinate downregulation of hepcidin and upregulation of erythropoietin and ferroportin, the VHL-HIF pathway mobilizes iron to support erythrocyte production.
0 Communities
1 Members
0 Resources
24 MeSH Terms