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Bioluminescence imaging reveals dynamics of beta cell loss in the non-obese diabetic (NOD) mouse model.
Virostko J, Radhika A, Poffenberger G, Dula AN, Moore DJ, Powers AC
(2013) PLoS One 8: e57784
MeSH Terms: Aging, Animals, Diabetes Mellitus, Experimental, Disease Models, Animal, Female, Genetic Heterogeneity, Hyperglycemia, Imaging, Three-Dimensional, Insulin-Secreting Cells, Luminescent Measurements, Mice, Mice, Inbred NOD, Mice, Transgenic, Models, Biological, Time Factors
Added October 24, 2013
0 Communities
4 Members
0 Resources
15 MeSH Terms
Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells.
Raap AK, Jahangir Tafrechi RS, van de Rijke FM, Pyle A, Wählby C, Szuhai K, Ravelli RB, de Coo RF, Rajasimha HK, Nilsson M, Chinnery PF, Samuels DC, Janssen GM
(2012) PLoS One 7: e52080
MeSH Terms: DNA, Mitochondrial, Evolution, Molecular, Genetic Heterogeneity, Genomic Instability, Humans, Mitochondrial Diseases, Mitosis, Mutation, Point Mutation
Added December 12, 2013
0 Communities
1 Members
0 Resources
9 MeSH Terms
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.
Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF
(2012) Nat Genet 44: 1282-5
MeSH Terms: Animals, DNA Polymerase gamma, DNA, Mitochondrial, DNA-Directed DNA Polymerase, Female, Fertility, Genetic Heterogeneity, Genome, Mitochondrial, Germ-Line Mutation, Mice, Mice, Inbred C57BL, Oocytes, RNA, RNA, Mitochondrial, RNA, Transfer, Met
Added December 12, 2013
0 Communities
1 Members
0 Resources
15 MeSH Terms
Comprehensive molecular portraits of human breast tumours.
Cancer Genome Atlas Network
(2012) Nature 490: 61-70
MeSH Terms: Breast Neoplasms, Class I Phosphatidylinositol 3-Kinases, DNA Copy Number Variations, DNA Methylation, DNA Mutational Analysis, Exome, Female, GATA3 Transcription Factor, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, BRCA1, Genes, Neoplasm, Genes, erbB-2, Genes, p53, Genetic Heterogeneity, Genome, Human, Genomics, Humans, MAP Kinase Kinase Kinase 1, MicroRNAs, Mutation, Oligonucleotide Array Sequence Analysis, Ovarian Neoplasms, Phosphatidylinositol 3-Kinases, Protein Array Analysis, Proteomics, RNA, Messenger, RNA, Neoplasm, Receptors, Estrogen, Retinoblastoma Protein
Added March 28, 2014
0 Communities
1 Members
0 Resources
30 MeSH Terms
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, Mangino M, Onland-Moret NC, Chen B, Eriksson J, Garcia M, Liu YM, Koster A, Lohman K, Lyytikäinen LP, Petersen AK, Prescott J, Stolk L, Vandenput L, Wood AR, Zhuang WV, Ruokonen A, Hartikainen AL, Pouta A, Bandinelli S, Biffar R, Brabant G, Cox DG, Chen Y, Cummings S, Ferrucci L, Gunter MJ, Hankinson SE, Martikainen H, Hofman A, Homuth G, Illig T, Jansson JO, Johnson AD, Karasik D, Karlsson M, Kettunen J, Kiel DP, Kraft P, Liu J, Ljunggren Ö, Lorentzon M, Maggio M, Markus MR, Mellström D, Miljkovic I, Mirel D, Nelson S, Morin Papunen L, Peeters PH, Prokopenko I, Raffel L, Reincke M, Reiner AP, Rexrode K, Rivadeneira F, Schwartz SM, Siscovick D, Soranzo N, Stöckl D, Tworoger S, Uitterlinden AG, van Gils CH, Vasan RS, Wichmann HE, Zhai G, Bhasin S, Bidlingmaier M, Chanock SJ, De Vivo I, Harris TB, Hunter DJ, Kähönen M, Liu S, Ouyang P, Spector TD, van der Schouw YT, Viikari J, Wallaschofski H, McCarthy MI, Frayling TM, Murray A, Franks S, Järvelin MR, de Jong FH, Raitakari O, Teumer A, Ohlsson C, Murabito JM, Perry JR
(2012) PLoS Genet 8: e1002805
MeSH Terms: Alleles, Female, Genetic Heterogeneity, Genome-Wide Association Study, Gonadal Steroid Hormones, Humans, Male, Metabolic Networks and Pathways, Polymorphism, Single Nucleotide, Sex Characteristics, Sex Hormone-Binding Globulin
Added March 14, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.
Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A, Zafarmand MH, Romaine SP, Mehta A, van Iperen EP, Gong Y, Price TS, Smith EN, Kim CE, Li YR, Asselbergs FW, Atwood LD, Bailey KM, Bhatt D, Bauer F, Behr ER, Bhangale T, Boer JM, Boehm BO, Bradfield JP, Brown M, Braund PS, Burton PR, Carty C, Chandrupatla HR, Chen W, Connell J, Dalgeorgou C, Boer Ad, Drenos F, Elbers CC, Fang JC, Fox CS, Frackelton EC, Fuchs B, Furlong CE, Gibson Q, Gieger C, Goel A, Grobbee DE, Hastie C, Howard PJ, Huang GH, Johnson WC, Li Q, Kleber ME, Klein BE, Klein R, Kooperberg C, Ky B, Lacroix A, Lanken P, Lathrop M, Li M, Marshall V, Melander O, Mentch FD, Meyer NJ, Monda KL, Montpetit A, Murugesan G, Nakayama K, Nondahl D, Onipinla A, Rafelt S, Newhouse SJ, Otieno FG, Patel SR, Putt ME, Rodriguez S, Safa RN, Sawyer DB, Schreiner PJ, Simpson C, Sivapalaratnam S, Srinivasan SR, Suver C, Swergold G, Sweitzer NK, Thomas KA, Thorand B, Timpson NJ, Tischfield S, Tobin M, Tomaszewski M, Tomaszweski M, Verschuren WM, Wallace C, Winkelmann B, Zhang H, Zheng D, Zhang L, Zmuda JM, Clarke R, Balmforth AJ, Danesh J, Day IN, Schork NJ, de Bakker PI, Delles C, Duggan D, Hingorani AD, Hirschhorn JN, Hofker MH, Humphries SE, Kivimaki M, Lawlor DA, Kottke-Marchant K, Mega JL, Mitchell BD, Morrow DA, Palmen J, Redline S, Shields DC, Shuldiner AR, Sleiman PM, Smith GD, Farrall M, Jamshidi Y, Christiani DC, Casas JP, Hall AS, Doevendans PA, Christie JD, Berenson GS, Murray SS, Illig T, Dorn GW, Cappola TP, Boerwinkle E, Sever P, Rader DJ, Reilly MP, Caulfield M, Talmud PJ, Topol E, Engert JC, Wang K, Dominiczak A, Hamsten A, Curtis SP, Silverstein RL, Lange LA, Sabatine MS, Trip M, Saleheen D, Peden JF, Cruickshanks KJ, März W, O'Connell JR, Klungel OH, Wijmenga C, Maitland-van der Zee AH, Schadt EE, Johnson JA, Jarvik GP, Papanicolaou GJ, Hugh Watkins on behalf of PROCARDIS, Grant SF, Munroe PB, North KE, Samani NJ, Koenig W, Gaunt TR, Anand SS, van der Schouw YT, Meena Kumari on behalf of the Whitehall II Study and the WHII 50K Group, Soranzo N, Fitzgerald GA, Reiner A, Hegele RA, Hakonarson H, Keating BJ
(2011) Am J Hum Genet 88: 6-18
MeSH Terms: Adult, African Americans, Asians, Body Height, Cardiovascular System, Female, Gene Frequency, Genetic Heterogeneity, Genetic Loci, Genome-Wide Association Study, Hispanic or Latino, Humans, Interleukin-11, Male, Polymorphism, Single Nucleotide, Smad3 Protein, Whites
Added May 28, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT.
Edwards TL, Turner SD, Torstenson ES, Dudek SM, Martin ER, Ritchie MD
(2010) PLoS One 5: e9363
MeSH Terms: Algorithms, Computational Biology, Epistasis, Genetic, Gene Frequency, Genetic Heterogeneity, Genetic Predisposition to Disease, Genotype, Humans, Models, Genetic, Multifactorial Inheritance, Polymorphism, Genetic, Regression Analysis
Added March 5, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Heterogeneity and the design of genetic studies in autism.
Sutcliffe JS
(2008) Autism Res 1: 205-6
MeSH Terms: Autistic Disorder, Genetic Heterogeneity, Genetic Variation, Humans
Added February 20, 2014
0 Communities
1 Members
0 Resources
4 MeSH Terms
Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models.
Edwards TL, Lewis K, Velez DR, Dudek S, Ritchie MD
(2009) Hum Hered 67: 183-92
MeSH Terms: Algorithms, Computer Simulation, Epistasis, Genetic, Genetic Heterogeneity, Genetic Predisposition to Disease, Humans, Models, Genetic, Odds Ratio, Polymorphism, Single Nucleotide, Software
Added March 5, 2014
0 Communities
3 Members
0 Resources
10 MeSH Terms
Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.
Thornton-Wells TA, Moore JH, Martin ER, Pericak-Vance MA, Haines JL
(2008) Genet Epidemiol 32: 187-203
MeSH Terms: Age of Onset, Aged, Alzheimer Disease, Cluster Analysis, Databases, Genetic, Epistasis, Genetic, Family, Genetic Heterogeneity, Genetic Markers, Genotype, Humans, Linkage Disequilibrium, Logistic Models
Added December 10, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms