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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 104

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EGF receptor is required for KRAS-induced pancreatic tumorigenesis.
Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT
(2012) Cancer Cell 22: 304-17
MeSH Terms: ADAM Proteins, ADAM17 Protein, Animals, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Cell Transformation, Neoplastic, Epithelial Cells, ErbB Receptors, Extracellular Signal-Regulated MAP Kinases, Genes, ras, Humans, Mice, Mice, Transgenic, Pancreas, Pancreatic Neoplasms, Proto-Oncogene Proteins p21(ras)
Added April 12, 2016
0 Communities
2 Members
0 Resources
16 MeSH Terms
Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.
Tsunoda T, Ota T, Fujimoto T, Doi K, Tanaka Y, Yoshida Y, Ogawa M, Matsuzaki H, Hamabashiri M, Tyson DR, Kuroki M, Miyamoto S, Shirasawa S
(2012) Mol Cancer 11: 46
MeSH Terms: Apoptosis, Cell Line, Tumor, Cluster Analysis, Colorectal Neoplasms, Cyclic Nucleotide Phosphodiesterases, Type 4, Enzyme Activation, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, ras, HCT116 Cells, Humans, Phosphodiesterase 4 Inhibitors, Phosphorylation, Proto-Oncogene Proteins c-akt, RNA Interference, Recurrence, Rolipram, Spheroids, Cellular, Tight Junctions, Tumor Cells, Cultured
Added February 27, 2013
0 Communities
1 Members
0 Resources
20 MeSH Terms
BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.
Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM
(2012) PLoS One 7: e41343
MeSH Terms: Antineoplastic Agents, Catalytic Domain, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Cell Separation, Cell Survival, Colonic Neoplasms, Drug Screening Assays, Antitumor, Flow Cytometry, Genes, ras, Genotype, Germinal Center Kinases, Humans, Models, Genetic, Mutation, Niacinamide, Protein-Serine-Threonine Kinases, Pyrimidines, Signal Transduction, raf Kinases
Added November 15, 2013
0 Communities
1 Members
0 Resources
21 MeSH Terms
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers.
Diaz LA, Williams RT, Wu J, Kinde I, Hecht JR, Berlin J, Allen B, Bozic I, Reiter JG, Nowak MA, Kinzler KW, Oliner KS, Vogelstein B
(2012) Nature 486: 537-40
MeSH Terms: Antibodies, Monoclonal, Colorectal Neoplasms, DNA, Neoplasm, Drug Resistance, Neoplasm, ErbB Receptors, Evolution, Molecular, Genes, ras, Humans, Mutation, Panitumumab, Proto-Oncogene Proteins, Proto-Oncogene Proteins p21(ras), Selection, Genetic, Time Factors, ras Proteins
Added March 20, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.
Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW
(2012) Angew Chem Int Ed Engl 51: 6140-3
MeSH Terms: Crystallography, X-Ray, Genes, ras, Molecular Structure, Small Molecule Libraries, Son of Sevenless Proteins
Added March 5, 2014
0 Communities
2 Members
0 Resources
5 MeSH Terms
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors.
Su F, Viros A, Milagre C, Trunzer K, Bollag G, Spleiss O, Reis-Filho JS, Kong X, Koya RC, Flaherty KT, Chapman PB, Kim MJ, Hayward R, Martin M, Yang H, Wang Q, Hilton H, Hang JS, Noe J, Lambros M, Geyer F, Dhomen N, Niculescu-Duvaz I, Zambon A, Niculescu-Duvaz D, Preece N, Robert L, Otte NJ, Mok S, Kee D, Ma Y, Zhang C, Habets G, Burton EA, Wong B, Nguyen H, Kockx M, Andries L, Lestini B, Nolop KB, Lee RJ, Joe AK, Troy JL, Gonzalez R, Hutson TE, Puzanov I, Chmielowski B, Springer CJ, McArthur GA, Sosman JA, Lo RS, Ribas A, Marais R
(2012) N Engl J Med 366: 207-15
MeSH Terms: Aged, Aged, 80 and over, Animals, Carcinoma, Squamous Cell, Female, Gene Expression, Gene Expression Regulation, Neoplastic, Genes, ras, Humans, Indoles, Male, Mice, Middle Aged, Mitogen-Activated Protein Kinase Kinases, Mutation, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Skin Neoplasms, Sulfonamides, Vemurafenib
Added March 5, 2014
0 Communities
2 Members
0 Resources
20 MeSH Terms
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
Clark PE, Polosukhina D, Love H, Correa H, Coffin C, Perlman EJ, de Caestecker M, Moses HL, Zent R
(2011) Am J Pathol 179: 3045-55
MeSH Terms: Animals, Apoptosis Regulatory Proteins, Cell Transformation, Neoplastic, Exons, Genes, ras, Humans, Inhibitor of Apoptosis Proteins, Kidney Neoplasms, Kidney Tubules, Proximal, MAP Kinase Signaling System, Mice, Mice, Transgenic, Mutation, Nuclear Proteins, PAX2 Transcription Factor, PAX8 Transcription Factor, Paired Box Transcription Factors, Phosphatidylinositol 3-Kinase, Phosphatidylinositol 3-Kinases, Repressor Proteins, Signal Transduction, Survivin, Wilms Tumor, beta Catenin
Added February 17, 2014
4 Communities
5 Members
0 Resources
24 MeSH Terms
Nomogram to predict the presence of EGFR activating mutation in lung adenocarcinoma.
Girard N, Sima CS, Jackman DM, Sequist LV, Chen H, Yang JC, Ji H, Waltman B, Rosell R, Taron M, Zakowski MF, Ladanyi M, Riely G, Pao W
(2012) Eur Respir J 39: 366-72
MeSH Terms: Adenocarcinoma, African Continental Ancestry Group, Aged, Asian Continental Ancestry Group, Carcinoma, Non-Small-Cell Lung, ErbB Receptors, European Continental Ancestry Group, Female, Genes, ras, Genetic Predisposition to Disease, Genotype, Hispanic Americans, Humans, Lung Neoplasms, Male, Middle Aged, Nomograms, Predictive Value of Tests, Retrospective Studies
Added September 3, 2013
0 Communities
2 Members
0 Resources
19 MeSH Terms
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, McKay C, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD
(2011) Mol Cell 42: 36-49
MeSH Terms: Aged, Animals, Cell Line, Transformed, Cell Proliferation, Cellular Senescence, Class I Phosphatidylinositol 3-Kinases, Disease Models, Animal, Enzyme Activation, Female, Gene Expression Regulation, Neoplastic, Genes, ras, Humans, Male, Mice, Mice, Knockout, Mice, Transgenic, Middle Aged, Mutation, Neoplasms, PTEN Phosphohydrolase, Pancreatic Neoplasms, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction
Added March 17, 2014
0 Communities
1 Members
0 Resources
24 MeSH Terms
A bioinformatics workflow for variant peptide detection in shotgun proteomics.
Li J, Su Z, Ma ZQ, Slebos RJ, Halvey P, Tabb DL, Liebler DC, Pao W, Zhang B
(2011) Mol Cell Proteomics 10: M110.006536
MeSH Terms: Algorithms, Amino Acid Sequence, Base Sequence, Carcinoma, Cell Line, Tumor, Colorectal Neoplasms, Computational Biology, Databases, Protein, Genes, ras, Humans, Mutant Proteins, Mutation, Neoplasm Proteins, Proteome, Proteomics, Sigmoid Neoplasms, Workflow
Added March 5, 2014
0 Communities
5 Members
0 Resources
17 MeSH Terms