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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 74

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Evidence against dopamine D1/D2 receptor heteromers.
Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA
(2015) Mol Psychiatry 20: 1373-85
MeSH Terms: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Animals, Corpus Striatum, Dopamine Agonists, Dopamine Antagonists, GTP-Binding Protein alpha Subunits, Gq-G11, Grooming, HEK293 Cells, Humans, Luminescent Proteins, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Molecular, Motor Activity, Nucleus Accumbens, Phosphorylation, Protein Multimerization, Protein Structure, Tertiary, Receptors, Dopamine D1, Receptors, Dopamine D2
Added January 20, 2015
0 Communities
2 Members
0 Resources
22 MeSH Terms
Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10.
Schwetz TA, Reissaus CA, Piston DW
(2014) PLoS One 9: e113020
MeSH Terms: Animals, Blood Glucose, Calcium, Calcium Signaling, GTP-Binding Protein alpha Subunits, GTP-Binding Protein beta Subunits, GTP-Binding Protein gamma Subunits, Glucagon-Like Peptide 1, Humans, Insulin, Insulin-Secreting Cells, Islets of Langerhans, Kisspeptins, Male, Mice, Oxidation-Reduction, Signal Transduction
Added January 20, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit.
Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE
(2014) J Biol Chem 289: 24475-87
MeSH Terms: Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Guanosine Diphosphate, Models, Molecular, Phenylalanine, Protein Conformation
Added January 20, 2015
1 Communities
2 Members
0 Resources
6 MeSH Terms
Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes.
Kimple ME, Neuman JC, Linnemann AK, Casey PJ
(2014) Exp Mol Med 46: e102
MeSH Terms: Animals, Diabetes Mellitus, Type 2, GTP-Binding Protein alpha Subunits, Humans, Insulin-Secreting Cells, Obesity, Receptor, Melatonin, MT2, Receptors, Adrenergic, alpha-1, Receptors, Prostaglandin
Added August 2, 2016
0 Communities
1 Members
0 Resources
9 MeSH Terms
Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses.
Ramikie TS, Nyilas R, Bluett RJ, Gamble-George JC, Hartley ND, Mackie K, Watanabe M, Katona I, Patel S
(2014) Neuron 81: 1111-1125
MeSH Terms: Amygdala, Animals, Calcium, Endocannabinoids, Excitatory Postsynaptic Potentials, G-Protein-Coupled Receptor Kinase 2, GTP-Binding Protein alpha Subunits, Gq-G11, Glutamic Acid, Male, Mice, Mice, Inbred ICR, Neurons, Receptor Protein-Tyrosine Kinases, Receptor, Cannabinoid, CB1, Receptors, Muscarinic, Signal Transduction, Synapses, Synaptic Transmission
Added January 20, 2015
0 Communities
1 Members
0 Resources
18 MeSH Terms
A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.
Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM
(2014) J Biol Chem 289: 11331-11341
MeSH Terms: Allosteric Regulation, Amino Acid Substitution, Animals, Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Gi-Go, Guanosine 5'-O-(3-Thiotriphosphate), Guanosine Diphosphate, Mutation, Missense, Protein Structure, Secondary, Rats
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation.
Wang Z, Filgueiras LR, Wang S, Serezani AP, Peters-Golden M, Jancar S, Serezani CH
(2014) J Immunol 192: 2349-56
MeSH Terms: Animals, Female, GTP-Binding Protein alpha Subunits, Gene Expression Regulation, Inflammation, Leukotriene B4, Macrophage Activation, Macrophages, Peritoneal, Mice, Mice, Knockout, MicroRNAs, Myeloid Differentiation Factor 88, Receptors, Leukotriene B4, Signal Transduction, Suppressor of Cytokine Signaling 1 Protein, Suppressor of Cytokine Signaling Proteins
Added May 4, 2017
0 Communities
1 Members
0 Resources
16 MeSH Terms
A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo.
Li JH, Jain S, McMillin SM, Cui Y, Gautam D, Sakamoto W, Lu H, Jou W, McGuinness OP, Gavrilova O, Wess J
(2013) Endocrinology 154: 3539-51
MeSH Terms: Animals, Antidiuretic Hormone Receptor Antagonists, Cells, Cultured, Diabetes Mellitus, Type 2, Enzyme Activators, Female, G-Protein-Coupled Receptor Kinases, GTP-Binding Protein alpha Subunits, Gq-G11, Gluconeogenesis, Glycogenolysis, Hepatocytes, Humans, Hypoglycemic Agents, Male, Mice, Mice, Obese, Mice, Transgenic, Protein Engineering, Protein Interaction Domains and Motifs, Receptor, Muscarinic M3, Receptors, Vasopressin, Recombinant Fusion Proteins, Specific Pathogen-Free Organisms
Added July 21, 2014
1 Communities
1 Members
1 Resources
23 MeSH Terms
High throughput mass spectrometry-based mutation profiling of primary uveal melanoma.
Daniels AB, Lee JE, MacConaill LE, Palescandolo E, Van Hummelen P, Adams SM, DeAngelis MM, Hahn WC, Gragoudas ES, Harbour JW, Garraway LA, Kim IK
(2012) Invest Ophthalmol Vis Sci 53: 6991-6
MeSH Terms: DNA Mutational Analysis, DNA, Neoplasm, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Amplification, Gene Expression Profiling, Humans, Melanoma, Mutation, Oncogenes, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Tumor Suppressor Proteins, Uveal Neoplasms
Added March 30, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials.
Lovly CM, Dahlman KB, Fohn LE, Su Z, Dias-Santagata D, Hicks DJ, Hucks D, Berry E, Terry C, Duke M, Su Y, Sobolik-Delmaire T, Richmond A, Kelley MC, Vnencak-Jones CL, Iafrate AJ, Sosman J, Pao W
(2012) PLoS One 7: e35309
MeSH Terms: Cell Line, Tumor, Clinical Trials as Topic, DNA Mutational Analysis, Eligibility Determination, GTP-Binding Protein alpha Subunits, GTP-Binding Protein alpha Subunits, Gq-G11, Genetic Testing, Humans, Male, Melanoma, Molecular Diagnostic Techniques, Nerve Tissue Proteins, Point Mutation, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-kit, Proto-Oncogene Proteins p21(ras), Skin Neoplasms
Added September 3, 2013
3 Communities
8 Members
0 Resources
17 MeSH Terms