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DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.
Ocak S, Yamashita H, Udyavar AR, Miller AN, Gonzalez AL, Zou Y, Jiang A, Yi Y, Shyr Y, Estrada L, Quaranta V, Massion PP
(2010) Oncogene 29: 6331-42
MeSH Terms: Carcinoma, Small Cell, Cell Adhesion, Cell Line, Tumor, Comparative Genomic Hybridization, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, Gene Dosage, Humans, Lung Neoplasms, Quinolones, Sulfones
Added February 27, 2013
2 Communities
6 Members
0 Resources
11 MeSH Terms
Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation.
Elias BC, Bhattacharya S, Ray RM, Johnson LR
(2010) Cell Adh Migr 4: 419-30
MeSH Terms: Cell Adhesion, Cell Line, Cell Movement, Enzyme Activation, Extracellular Matrix, Fibronectins, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, Guanine Nucleotide Exchange Factors, Models, Biological, Oligopeptides, Polyamines, Protein Binding, Signal Transduction, rac1 GTP-Binding Protein, src-Family Kinases
Added February 25, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Laminin-332-beta1 integrin interactions negatively regulate invadopodia.
Liu S, Yamashita H, Weidow B, Weaver AM, Quaranta V
(2010) J Cell Physiol 223: 134-42
MeSH Terms: Animals, Carcinoma, Cell Adhesion, Cell Adhesion Molecules, Cell Line, Tumor, Cell Movement, Collagen Type I, Focal Adhesion Protein-Tyrosine Kinases, Integrin alpha3beta1, Integrin beta1, Neoplasm Invasiveness, Protein Kinase Inhibitors, Pseudopodia, RNA Interference, Rats, Transfection, Urinary Bladder Neoplasms, src-Family Kinases
Added February 18, 2013
3 Communities
2 Members
0 Resources
18 MeSH Terms
Focal adhesion kinase-dependent regulation of adhesive forces involves vinculin recruitment to focal adhesions.
Dumbauld DW, Michael KE, Hanks SK, García AJ
(2010) Biol Cell 102: 203-213
MeSH Terms: Cell Adhesion, Cells, Cultured, Down-Regulation, Extracellular Matrix, Fibroblasts, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, Gene Expression, Humans, Mutation, Vinculin
Added January 20, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion.
Gao J, McConnell MJ, Yu B, Li J, Balko JM, Black EP, Johnson JO, Lloyd MC, Altiok S, Haura EB
(2009) Int J Oncol 35: 337-45
MeSH Terms: Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Survival, Cisplatin, Focal Adhesion Protein-Tyrosine Kinases, Humans, Lung Neoplasms, Mucin-1, Neoplasm Invasiveness, Phosphorylation, Proto-Oncogene Proteins c-akt, STAT3 Transcription Factor, Signal Transduction
Added March 10, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/mass spectrometry.
Ciccimaro E, Hanks SK, Yu KH, Blair IA
(2009) Anal Chem 81: 3304-13
MeSH Terms: Amino Acid Sequence, Chromatography, Liquid, Enzyme Activation, Focal Adhesion Protein-Tyrosine Kinases, Humans, Immunoprecipitation, Isotope Labeling, Mass Spectrometry, Molecular Sequence Data, Peptides, Phosphorylation, Reproducibility of Results, Trypsin
Added January 20, 2015
0 Communities
1 Members
0 Resources
13 MeSH Terms
Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.
Michael KE, Dumbauld DW, Burns KL, Hanks SK, García AJ
(2009) Mol Biol Cell 20: 2508-19
MeSH Terms: Animals, Biomechanical Phenomena, Cell Adhesion, Fibroblasts, Fibronectins, Focal Adhesion Protein-Tyrosine Kinases, Gene Knockdown Techniques, Humans, Integrin alpha5beta1, Integrins, Kinetics, Mice, Phosphorylation, Phosphotyrosine, Protein Binding, Solubility, Talin, Tetracycline, Vinculin
Added January 20, 2015
0 Communities
1 Members
0 Resources
19 MeSH Terms
Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activity.
Ciccimaro E, Hanks SK, Blair IA
(2009) Mol Pharmacol 75: 658-66
MeSH Terms: Animals, Biomarkers, Cell Line, Dose-Response Relationship, Drug, Enzyme Activation, Focal Adhesion Protein-Tyrosine Kinases, Humans, Mice, Phosphorylation, Protease Inhibitors, src-Family Kinases
Added January 20, 2015
0 Communities
1 Members
0 Resources
11 MeSH Terms
Dissection of the osteogenic effects of laminin-332 utilizing specific LG domains: LG3 induces osteogenic differentiation, but not mineralization.
Klees RF, Salasznyk RM, Ward DF, Crone DE, Williams WA, Harris MP, Boskey A, Quaranta V, Plopper GE
(2008) Exp Cell Res 314: 763-73
MeSH Terms: Calcification, Physiologic, Cell Adhesion, Cell Adhesion Molecules, Cell Differentiation, Cells, Cultured, Core Binding Factor Alpha 1 Subunit, Extracellular Signal-Regulated MAP Kinases, Focal Adhesion Protein-Tyrosine Kinases, Humans, Integrin alpha3beta1, Mesenchymal Stem Cells, Osteoblasts, Peptides, Protein Structure, Tertiary, Sp7 Transcription Factor, Transcription Factors
Added February 18, 2013
2 Communities
1 Members
0 Resources
16 MeSH Terms
Asymmetric focal adhesion disassembly in motile cells.
Broussard JA, Webb DJ, Kaverina I
(2008) Curr Opin Cell Biol 20: 85-90
MeSH Terms: Actins, Animals, Cell Movement, Cell Polarity, Focal Adhesion Protein-Tyrosine Kinases, Focal Adhesions, Humans, Microtubules
Added December 10, 2013
0 Communities
2 Members
0 Resources
8 MeSH Terms