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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 91

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Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates.
Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, Morrissey JH, Gruber A, McCarty OJ
(2013) J Thromb Haemost 11: 1341-52
MeSH Terms: Animals, Antibodies, Neutralizing, Blood Coagulation, Factor XI, Factor XI Deficiency, Factor XII, Factor XIIa, Factor XIa, Humans, Plant Proteins, Polyphosphates, Prothrombin, Thrombin, Thrombosis, Time Factors
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa.
Geng Y, Verhamme IM, Sun MF, Bajaj SP, Emsley J, Gailani D
(2013) J Thromb Haemost 11: 1374-84
MeSH Terms: Arginine, Blood Coagulation, Blood Coagulation Tests, Enzyme Activation, Factor IX, Factor XI Deficiency, Factor XIa, Glycine, HEK293 Cells, Humans, Kinetics, Models, Molecular, Mutation, Protein Binding, Protein Conformation, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Structure-Activity Relationship, Transfection
Added May 19, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.
Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP
(2013) Arterioscler Thromb Vasc Biol 33: 1670-8
MeSH Terms: Animals, Antibodies, Monoclonal, Arteriovenous Shunt, Surgical, Bleeding Time, Blood Coagulation, Collagen, Disease Models, Animal, Dose-Response Relationship, Drug, Down-Regulation, Factor XI, Fibrinolytic Agents, Hemorrhage, Macaca fascicularis, Oligonucleotides, Antisense, Papio, Thrombin, Thrombosis, Time Factors
Added May 19, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
The dimeric structure of factor XI and zymogen activation.
Geng Y, Verhamme IM, Smith SB, Sun MF, Matafonov A, Cheng Q, Smith SA, Morrissey JH, Gailani D
(2013) Blood 121: 3962-9
MeSH Terms: Animals, Carotid Artery Thrombosis, Factor XI, Factor XI Deficiency, Factor XIIa, Factor XIa, HEK293 Cells, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Biological, Protein Binding, Protein Multimerization, Protein Structure, Quaternary
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.
Karuturi R, Al-Horani RA, Mehta SC, Gailani D, Desai UR
(2013) J Med Chem 56: 2415-28
MeSH Terms: Allosteric Regulation, Biomimetic Materials, Catalytic Domain, Drug Discovery, Factor XIa, Glycosaminoglycans, Heparin, Humans, Hydrophobic and Hydrophilic Interactions, Protease Inhibitors, Quinazolinones, Sulfates
Added May 19, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa.
Al-Horani RA, Ponnusamy P, Mehta AY, Gailani D, Desai UR
(2013) J Med Chem 56: 867-78
MeSH Terms: Allosteric Regulation, Carbohydrate Sequence, Chromatography, Liquid, Enzyme Activation, Factor XIa, Glucosides, Hydrolysis, Kinetics, Magnetic Resonance Spectroscopy, Molecular Mimicry, Molecular Sequence Data, Serine Proteinase Inhibitors, Spectrometry, Mass, Electrospray Ionization, Sulfuric Acid Esters, Thrombelastography
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
A sequential mechanism for exosite-mediated factor IX activation by factor XIa.
Geng Y, Verhamme IM, Messer A, Sun MF, Smith SB, Bajaj SP, Gailani D
(2012) J Biol Chem 287: 38200-9
MeSH Terms: Arginine, Binding Sites, Binding, Competitive, Biocatalysis, Calcium, Catalytic Domain, Electrophoresis, Polyacrylamide Gel, Factor IX, Factor IXa, Factor XIa, HEK293 Cells, Humans, Kinetics, Mutation, Oligopeptides, Protein Multimerization, Proteolysis, Pyrrolidonecarboxylic Acid, Recombinant Proteins, Substrate Specificity
Added May 19, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis.
Tucker EI, Verbout NG, Leung PY, Hurst S, McCarty OJ, Gailani D, Gruber A
(2012) Blood 119: 4762-8
MeSH Terms: Animals, Antibodies, Monoclonal, Anticoagulants, Blood Coagulation Disorders, Coinfection, Down-Regulation, Factor XIa, Immunotherapy, Inflammation, Male, Mice, Mice, Inbred C57BL, Protein C, Sepsis, Survival Analysis
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
A cofactor for factor XI activation.
Gailani D
(2011) Blood 118: 6730-1
MeSH Terms: Factor XI, Factor XIa, Humans, Polyphosphates, Thrombin
Added May 19, 2014
0 Communities
1 Members
0 Resources
5 MeSH Terms
Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis.
Luo D, Szaba FM, Kummer LW, Johnson LL, Tucker EI, Gruber A, Gailani D, Smiley ST
(2012) Infect Immun 80: 91-9
MeSH Terms: Animals, Anti-Bacterial Agents, Antibodies, Disseminated Intravascular Coagulation, Drug Therapy, Combination, Factor XI Deficiency, Inflammation, Listeria monocytogenes, Listeriosis, Liver, Mice, Mice, Inbred C57BL, Mice, Knockout, Survival Analysis, Treatment Outcome
Added May 19, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms