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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 85

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Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer.
Young CD, Zimmerman LJ, Hoshino D, Formisano L, Hanker AB, Gatza ML, Morrison MM, Moore PD, Whitwell CA, Dave B, Stricker T, Bhola NE, Silva GO, Patel P, Brantley-Sieders DM, Levin M, Horiates M, Palma NA, Wang K, Stephens PJ, Perou CM, Weaver AM, O'Shaughnessy JA, Chang JC, Park BH, Liebler DC, Cook RS, Arteaga CL
(2015) Mol Cell Proteomics 14: 1959-76
MeSH Terms: Amphiregulin, Animals, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Chromatography, Liquid, Class I Phosphatidylinositol 3-Kinases, Disease-Free Survival, Down-Regulation, Epidermal Growth Factor, ErbB Receptors, Extracellular Matrix, Extracellular Signal-Regulated MAP Kinases, Female, Humans, Mice, Nude, Mutation, Neoplasm Proteins, Paracrine Communication, Phosphatidylinositol 3-Kinases, Protein Binding, Protein Kinase Inhibitors, Proteomics, Signal Transduction, Tandem Mass Spectrometry, Up-Regulation
Added February 15, 2016
1 Communities
3 Members
0 Resources
26 MeSH Terms
Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δ.
Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS
(2014) Invest Ophthalmol Vis Sci 55: 8232-40
MeSH Terms: Analysis of Variance, Animals, Capillary Permeability, Cell Membrane, Cells, Cultured, Claudin-1, Claudin-5, Electric Impedance, Endothelial Cells, Extracellular Signal-Regulated MAP Kinases, Humans, Immunohistochemistry, MAP Kinase Signaling System, Mice, Mice, Inbred C57BL, Models, Animal, Peroxisome Proliferator-Activated Receptors, Receptors, Vascular Endothelial Growth Factor, Retina, Retinal Vessels, Sulfones, Thiophenes, Vascular Endothelial Growth Factor A
Added February 19, 2015
1 Communities
1 Members
0 Resources
23 MeSH Terms
The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury.
Tchantchou F, Tucker LB, Fu AH, Bluett RJ, McCabe JT, Patel S, Zhang Y
(2014) Neuropharmacology 85: 427-39
MeSH Terms: Amidohydrolases, Animals, Anxiety, Brain, Brain Injuries, Caspase 3, Disease Models, Animal, Extracellular Signal-Regulated MAP Kinases, Male, Memory Disorders, Mice, Inbred C57BL, Motor Activity, Neuroimmunomodulation, Neuroprotective Agents, Piperidines, Proto-Oncogene Proteins c-akt, Pyridines, Receptor, Cannabinoid, CB1, Receptor, Cannabinoid, CB2, Recovery of Function
Added January 20, 2015
0 Communities
1 Members
0 Resources
20 MeSH Terms
Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1.
Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE
(2014) J Biol Chem 289: 4219-32
MeSH Terms: Amino Acid Substitution, Animals, Cattle, Cell Line, Extracellular Signal-Regulated MAP Kinases, Glycoproteins, Humans, Multienzyme Complexes, Mutation, Missense, Phosphorylation, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-raf, Proto-Oncogene Proteins p21(ras), Rats, rac1 GTP-Binding Protein, ras Proteins
Added March 26, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma.
Yoshida S, Kornek M, Ikenaga N, Schmelzle M, Masuzaki R, Csizmadia E, Wu Y, Robson SC, Schuppan D
(2013) Hepatology 58: 1667-80
MeSH Terms: Adult, Aged, Animals, Carcinoma, Hepatocellular, Catheter Ablation, Cell Proliferation, Cell Survival, Epithelial-Mesenchymal Transition, Extracellular Signal-Regulated MAP Kinases, Female, Heat-Shock Proteins, Hep G2 Cells, Humans, Liver Neoplasms, Male, Mice, Mice, Inbred BALB C, Middle Aged, Phosphorylation, Shc Signaling Adaptor Proteins, Src Homology 2 Domain-Containing, Transforming Protein 1
Added May 2, 2014
0 Communities
1 Members
0 Resources
21 MeSH Terms
The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.
Ono K, Karolak MR, Ndong Jde L, Wang W, Yang X, Elefteriou F
(2013) Hum Mol Genet 22: 3048-62
MeSH Terms: Animals, Apoptosis, Cell Proliferation, Chondrocytes, Chondrogenesis, Extracellular Signal-Regulated MAP Kinases, Gene Expression, Growth Plate, Mice, Knockout, Neurofibromin 1, Osteogenesis, Receptors, Fibroblast Growth Factor, Signal Transduction
Added November 14, 2013
0 Communities
3 Members
0 Resources
13 MeSH Terms
A two-hit mechanism for sepsis-induced impairment of renal tubule function.
Watts BA, George T, Sherwood ER, Good DW
(2013) Am J Physiol Renal Physiol 304: F863-74
MeSH Terms: Absorption, Aldosterone, Amiloride, Animals, Bicarbonates, Cecum, Extracellular Signal-Regulated MAP Kinases, Flavonoids, Kidney Tubules, Ligation, Lipopolysaccharides, Loop of Henle, Mice, Mice, Inbred C57BL, Sepsis, Toll-Like Receptor 4, Up-Regulation
Added October 18, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Epoxyeicosatrienoic acids (EETs) regulate epithelial sodium channel activity by extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated phosphorylation.
Pidkovka N, Rao R, Mei S, Gong Y, Harris RC, Wang WH, Capdevila JH
(2013) J Biol Chem 288: 5223-31
MeSH Terms: 8,11,14-Eicosatrienoic Acid, Animals, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antihypertensive Agents, Cetuximab, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 2, Epidermal Growth Factor, Epithelial Sodium Channels, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Humans, Hypertension, Kidney, Male, Mice, Models, Biological, Phosphorylation
Added August 19, 2013
1 Communities
1 Members
0 Resources
19 MeSH Terms
Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma.
Blix ES, Irish JM, Husebekk A, Delabie J, Forfang L, Tierens AM, Myklebust JH, Kolstad A
(2012) BMC Cancer 12: 478
MeSH Terms: CD40 Antigens, CD40 Ligand, CD79 Antigens, Cluster Analysis, Extracellular Signal-Regulated MAP Kinases, Flow Cytometry, Humans, Interleukins, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell, Lymphoma, B-Cell, Marginal Zone, Models, Biological, Phospholipase C gamma, Phosphoproteins, Phosphorylation, Receptors, Antigen, B-Cell, STAT5 Transcription Factor, STAT6 Transcription Factor, Signal Transduction, T-Lymphocytes, Transcription Factor RelA
Added February 15, 2013
1 Communities
1 Members
0 Resources
21 MeSH Terms
EGF receptor is required for KRAS-induced pancreatic tumorigenesis.
Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT
(2012) Cancer Cell 22: 304-17
MeSH Terms: ADAM Proteins, ADAM17 Protein, Animals, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Cell Transformation, Neoplastic, Epithelial Cells, ErbB Receptors, Extracellular Signal-Regulated MAP Kinases, Genes, ras, Humans, Mice, Mice, Transgenic, Pancreas, Pancreatic Neoplasms, Proto-Oncogene Proteins p21(ras)
Added April 12, 2016
0 Communities
2 Members
0 Resources
16 MeSH Terms