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Results: 11 to 15 of 15

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Breaking the gene barrier in schizophrenia.
Horváth S, Mirnics K
(2009) Nat Med 15: 488-90
MeSH Terms: Animals, Brain, Cognition, ERG1 Potassium Channel, Emotions, Ether-A-Go-Go Potassium Channels, Genetic Predisposition to Disease, Hippocampus, Homeostasis, Humans, Mental Disorders, Polymorphism, Single Nucleotide, Primates, RNA, Messenger, Rodentia, Schizophrenia, Schizophrenic Psychology
Added May 19, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
The evolutionarily conserved residue A653 plays a key role in HERG channel closing.
Stepanovic SZ, Potet F, Petersen CI, Smith JA, Meiler J, Balser JR, Kupershmidt S
(2009) J Physiol 587: 2555-66
MeSH Terms: Alanine, Amino Acid Sequence, Animals, CHO Cells, Computer Simulation, Conserved Sequence, Cricetinae, Cricetulus, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, Evolution, Molecular, Humans, Ion Channel Gating, Kinetics, Membrane Potentials, Models, Molecular, Molecular Sequence Data, Mutation, Oocytes, Phenethylamines, Potassium Channel Blockers, Protein Conformation, Structure-Activity Relationship, Sulfonamides, Transfection, Xenopus laevis
Added January 24, 2015
1 Communities
1 Members
0 Resources
26 MeSH Terms
Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and ibutilide-induced block of HERG.
McBride BF, Yang T, Roden DM
(2009) Pharmacogenomics J 9: 194-201
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Animals, Anti-Arrhythmia Agents, CHO Cells, Cricetinae, Cricetulus, Dose-Response Relationship, Drug, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels, Haplotypes, Humans, Microscopy, Confocal, Microscopy, Fluorescence, Protein Transport, Sulfonamides
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator.
Potet F, Petersen CI, Boutaud O, Shuai W, Stepanovic SZ, Balser JR, Kupershmidt S
(2009) J Mol Cell Cardiol 46: 257-67
MeSH Terms: Animals, Arrhythmias, Cardiac, Caenorhabditis elegans, Caenorhabditis elegans Proteins, ERG1 Potassium Channel, Electrophysiology, Ether-A-Go-Go Potassium Channels, GTPase-Activating Proteins, Humans, Long QT Syndrome, Potassium, Potassium Channels, RNA Interference
Added March 27, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes.
Yang P, Kanki H, Drolet B, Yang T, Wei J, Viswanathan PC, Hohnloser SH, Shimizu W, Schwartz PJ, Stanton M, Murray KT, Norris K, George AL, Roden DM
(2002) Circulation 105: 1943-8
MeSH Terms: Alleles, Animals, Anti-Arrhythmia Agents, CHO Cells, Cation Transport Proteins, Cell Line, Cricetinae, DNA-Binding Proteins, ERG1 Potassium Channel, Electric Conductivity, Ether-A-Go-Go Potassium Channels, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Humans, KCNQ Potassium Channels, KCNQ1 Potassium Channel, Long QT Syndrome, Male, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Polymorphism, Genetic, Potassium Channels, Potassium Channels, Voltage-Gated, Sodium Channels, Torsades de Pointes, Trans-Activators, Transcriptional Regulator ERG
Added January 20, 2015
0 Communities
1 Members
0 Resources
29 MeSH Terms