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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 132

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Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
Felts AS, Bollinger KA, Brassard CJ, Rodriguez AL, Morrison RD, Scott Daniels J, Blobaum AL, Niswender CM, Jones CK, Conn PJ, Emmitte KA, Lindsley CW
(2019) Bioorg Med Chem Lett 29: 47-50
MeSH Terms: Allosteric Regulation, Animals, Dose-Response Relationship, Drug, Drug Discovery, Humans, Ligands, Molecular Structure, Picolinic Acids, Rats, Receptor, Metabotropic Glutamate 5, Structure-Activity Relationship
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels.
Kozek KA, Du Y, Sharma S, Prael FJ, Spitznagel BD, Kharade SV, Denton JS, Hopkins CR, Weaver CD
(2019) ACS Chem Neurosci 10: 358-370
MeSH Terms: Dose-Response Relationship, Drug, Drug Discovery, G Protein-Coupled Inwardly-Rectifying Potassium Channels, HEK293 Cells, Humans, Ion Channel Gating, Neurons, Pyrazines
Added April 10, 2019
0 Communities
1 Members
0 Resources
8 MeSH Terms
Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M Positive Allosteric Modulators.
Engers JL, Bender AM, Kalbfleisch JJ, Cho HP, Lingenfelter KS, Luscombe VB, Han C, Melancon BJ, Blobaum AL, Dickerson JW, Rook JM, Niswender CM, Emmitte KA, Conn PJ, Lindsley CW
(2019) ACS Chem Neurosci 10: 1035-1042
MeSH Terms: Allosteric Regulation, Animals, Drug Discovery, Humans, Imidazoles, Lactams, Mice, Muscarinic Agonists, Pyridines, Rats, Receptor, Muscarinic M1
Added March 3, 2020
0 Communities
2 Members
0 Resources
11 MeSH Terms
Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu positive allosteric modulators that mitigate CYP1A2 induction liability.
Engers DW, Bollinger SR, Engers JL, Panarese JD, Breiner MM, Gregro A, Blobaum AL, Bronson JJ, Wu YJ, Macor JE, Rodriguez AL, Zamorano R, Conn PJ, Lindsley CW, Niswender CM, Hopkins CR
(2018) Bioorg Med Chem Lett 28: 2641-2646
MeSH Terms: Allosteric Regulation, Animals, Antiparkinson Agents, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inducers, Drug Discovery, Enzyme Induction, Humans, Pyrazoles, Pyridines, Rats, Receptors, Metabotropic Glutamate, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Evaluating statistical approaches to leverage large clinical datasets for uncovering therapeutic and adverse medication effects.
Choi L, Carroll RJ, Beck C, Mosley JD, Roden DM, Denny JC, Van Driest SL
(2018) Bioinformatics 34: 2988-2996
MeSH Terms: Datasets as Topic, Drug Discovery, Drug-Related Side Effects and Adverse Reactions, Electronic Health Records, Humans, Logistic Models, Probability
Added March 24, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
The discovery of VU0486846: steep SAR from a series of M PAMs based on a novel benzomorpholine core.
Bertron JL, Cho HP, Garcia-Barrantes PM, Panarese JD, Salovich JM, Nance KD, Engers DW, Rook JM, Blobaum AL, Niswender CM, Stauffer SR, Conn PJ, Lindsley CW
(2018) Bioorg Med Chem Lett 28: 2175-2179
MeSH Terms: Animals, CHO Cells, Cricetulus, Drug Discovery, Humans, Molecular Structure, Morpholines, Pyrazoles, Rats, Receptor, Muscarinic M1, Structure-Activity Relationship
Added March 3, 2020
0 Communities
2 Members
0 Resources
MeSH Terms
In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers.
Cai C, Fang J, Guo P, Wang Q, Hong H, Moslehi J, Cheng F
(2018) J Chem Inf Model 58: 943-956
MeSH Terms: Antineoplastic Agents, Cardiovascular System, Computational Biology, Computer Simulation, Drug Discovery, Drug-Related Side Effects and Adverse Reactions, Humans, Molecular Targeted Therapy, Myocytes, Cardiac, Pluripotent Stem Cells, Product Surveillance, Postmarketing, Safety
Added October 1, 2018
0 Communities
1 Members
0 Resources
12 MeSH Terms
Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
Felts AS, Rodriguez AL, Morrison RD, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA
(2018) Bioorg Med Chem Lett 28: 1679-1685
MeSH Terms: Allosteric Regulation, Animals, Dose-Response Relationship, Drug, Drug Discovery, Humans, Male, Molecular Structure, Pyrimidines, Quinolines, Rats, Rats, Sprague-Dawley, Receptor, Metabotropic Glutamate 5, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Discovery and Optimization of Potent and CNS Penetrant M-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold.
Bender AM, Cho HP, Nance KD, Lingenfelter KS, Luscombe VB, Gentry PR, Voigtritter K, Berizzi AE, Sexton PM, Langmead CJ, Christopoulos A, Locuson CW, Bridges TM, Chang S, O'Neill JC, Zhan X, Niswender CM, Jones CK, Conn PJ, Lindsley CW
(2018) ACS Chem Neurosci 9: 1572-1581
MeSH Terms: Allosteric Regulation, Amides, Animals, Brain, Cholinergic Agents, Drug Discovery, Humans, Male, Microsomes, Liver, Molecular Structure, Piperidines, Rats, Sprague-Dawley, Receptors, Muscarinic, Structure-Activity Relationship
Added March 3, 2020
0 Communities
1 Members
0 Resources
MeSH Terms
Improving the discovery of secondary metabolite natural products using ion mobility-mass spectrometry.
Schrimpe-Rutledge AC, Sherrod SD, McLean JA
(2018) Curr Opin Chem Biol 42: 160-166
MeSH Terms: Biological Products, Drug Discovery, Ion Mobility Spectrometry, Mass Spectrometry, Metabolomics, Molecular Structure, Workflow
Added December 17, 2018
1 Communities
1 Members
0 Resources
7 MeSH Terms