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Results: 11 to 17 of 17
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7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.
Xu L, Sheflin LG, Porter NA, Fliesler SJ
(2012) Biochim Biophys Acta 1821: 877-83
MeSH Terms: Animals, Animals, Newborn, Cholesterol, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Female, Humans, Ketocholesterols, Male, Mass Spectrometry, Molecular Structure, Pregnancy, Rats, Rats, Sprague-Dawley, Retina, Retinal Degeneration, Smith-Lemli-Opitz Syndrome, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Added March 20, 2014
Xu L, Sheflin LG, Porter NA, Fliesler SJ
(2012) Biochim Biophys Acta 1821: 877-83
MeSH Terms: Animals, Animals, Newborn, Cholesterol, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Female, Humans, Ketocholesterols, Male, Mass Spectrometry, Molecular Structure, Pregnancy, Rats, Rats, Sprague-Dawley, Retina, Retinal Degeneration, Smith-Lemli-Opitz Syndrome, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Added March 20, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
1 Members
0 Resources
19 MeSH Terms
DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model.
Xu L, Mirnics K, Bowman AB, Liu W, Da J, Porter NA, Korade Z
(2012) Neurobiol Dis 45: 923-9
MeSH Terms: Animals, Astrocytes, Brain, Cell Survival, Cells, Cultured, Cholestenones, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Dose-Response Relationship, Drug, Embryo, Mammalian, Mice, Mice, Knockout, Nerve Tissue Proteins, Neurons, Oxidoreductases Acting on CH-CH Group Donors, Smith-Lemli-Opitz Syndrome, Tandem Mass Spectrometry
Added March 7, 2014
Xu L, Mirnics K, Bowman AB, Liu W, Da J, Porter NA, Korade Z
(2012) Neurobiol Dis 45: 923-9
MeSH Terms: Animals, Astrocytes, Brain, Cell Survival, Cells, Cultured, Cholestenones, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Dose-Response Relationship, Drug, Embryo, Mammalian, Mice, Mice, Knockout, Nerve Tissue Proteins, Neurons, Oxidoreductases Acting on CH-CH Group Donors, Smith-Lemli-Opitz Syndrome, Tandem Mass Spectrometry
Added March 7, 2014
1 Communities
3 Members
0 Resources
18 MeSH Terms
3 Members
0 Resources
18 MeSH Terms
Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.
Xu L, Liu W, Sheflin LG, Fliesler SJ, Porter NA
(2011) J Lipid Res 52: 1810-20
MeSH Terms: Animals, Anticholesteremic Agents, Cholestenones, Cholesterol, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Hydroxycholesterols, Ketocholesterols, Lipid Peroxidation, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Rats, Rats, Sprague-Dawley, Smith-Lemli-Opitz Syndrome, Spectrophotometry, Ultraviolet, Sterols, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Added March 7, 2014
Xu L, Liu W, Sheflin LG, Fliesler SJ, Porter NA
(2011) J Lipid Res 52: 1810-20
MeSH Terms: Animals, Anticholesteremic Agents, Cholestenones, Cholesterol, Chromatography, High Pressure Liquid, Dehydrocholesterols, Disease Models, Animal, Hydroxycholesterols, Ketocholesterols, Lipid Peroxidation, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Rats, Rats, Sprague-Dawley, Smith-Lemli-Opitz Syndrome, Spectrophotometry, Ultraviolet, Sterols, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride
Added March 7, 2014
0 Communities
1 Members
0 Resources
19 MeSH Terms
1 Members
0 Resources
19 MeSH Terms
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate.
Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP
(2011) J Biol Chem 286: 33021-8
MeSH Terms: Biocatalysis, Cholesterol, Cholesterol 7-alpha-Hydroxylase, Chromatography, Liquid, Cytochrome P-450 Enzyme System, Dehydrocholesterols, Epoxy Compounds, Humans, Ketocholesterols, Mass Spectrometry, Microsomes, Liver, Oxidation-Reduction, Recombinant Proteins
Added March 7, 2014
Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP
(2011) J Biol Chem 286: 33021-8
MeSH Terms: Biocatalysis, Cholesterol, Cholesterol 7-alpha-Hydroxylase, Chromatography, Liquid, Cytochrome P-450 Enzyme System, Dehydrocholesterols, Epoxy Compounds, Humans, Ketocholesterols, Mass Spectrometry, Microsomes, Liver, Oxidation-Reduction, Recombinant Proteins
Added March 7, 2014
0 Communities
2 Members
0 Resources
13 MeSH Terms
2 Members
0 Resources
13 MeSH Terms
An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.
Xu L, Korade Z, Rosado JDA, Liu W, Lamberson CR, Porter NA
(2011) J Lipid Res 52: 1222-1233
MeSH Terms: Animals, Antioxidants, Biomarkers, Brain, Cell Line, Tumor, Cholestenones, Chromatography, High Pressure Liquid, Chromatography, Liquid, Dehydrocholesterols, Disease Models, Animal, Embryo, Mammalian, Female, Fibroblasts, Humans, Isotope Labeling, Mass Spectrometry, Mice, Mice, Knockout, Oxidation-Reduction, Oxidoreductases Acting on CH-CH Group Donors, Pregnancy, Reference Standards, Smith-Lemli-Opitz Syndrome
Added March 7, 2014
Xu L, Korade Z, Rosado JDA, Liu W, Lamberson CR, Porter NA
(2011) J Lipid Res 52: 1222-1233
MeSH Terms: Animals, Antioxidants, Biomarkers, Brain, Cell Line, Tumor, Cholestenones, Chromatography, High Pressure Liquid, Chromatography, Liquid, Dehydrocholesterols, Disease Models, Animal, Embryo, Mammalian, Female, Fibroblasts, Humans, Isotope Labeling, Mass Spectrometry, Mice, Mice, Knockout, Oxidation-Reduction, Oxidoreductases Acting on CH-CH Group Donors, Pregnancy, Reference Standards, Smith-Lemli-Opitz Syndrome
Added March 7, 2014
0 Communities
1 Members
0 Resources
23 MeSH Terms
1 Members
0 Resources
23 MeSH Terms
Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome.
Korade Z, Xu L, Shelton R, Porter NA
(2010) J Lipid Res 51: 3259-69
MeSH Terms: Animals, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Cell Survival, Dehydrocholesterols, Dose-Response Relationship, Drug, Gene Expression Profiling, Mice, Neurons, Oxidation-Reduction, Oxidoreductases Acting on CH-CH Group Donors, Peroxides, Smith-Lemli-Opitz Syndrome, Time Factors
Added March 7, 2014
Korade Z, Xu L, Shelton R, Porter NA
(2010) J Lipid Res 51: 3259-69
MeSH Terms: Animals, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Cell Survival, Dehydrocholesterols, Dose-Response Relationship, Drug, Gene Expression Profiling, Mice, Neurons, Oxidation-Reduction, Oxidoreductases Acting on CH-CH Group Donors, Peroxides, Smith-Lemli-Opitz Syndrome, Time Factors
Added March 7, 2014
0 Communities
1 Members
0 Resources
15 MeSH Terms
1 Members
0 Resources
15 MeSH Terms
Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies.
Xu L, Korade Z, Porter NA
(2010) J Am Chem Soc 132: 2222-32
MeSH Terms: Animals, Azo Compounds, Cell Line, Tumor, Cell Survival, Dehydrocholesterols, Free Radicals, Mice, Neuroblastoma, Nitriles, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Rats, Sterols
Added March 7, 2014
Xu L, Korade Z, Porter NA
(2010) J Am Chem Soc 132: 2222-32
MeSH Terms: Animals, Azo Compounds, Cell Line, Tumor, Cell Survival, Dehydrocholesterols, Free Radicals, Mice, Neuroblastoma, Nitriles, Nuclear Magnetic Resonance, Biomolecular, Oxidation-Reduction, Rats, Sterols
Added March 7, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
1 Members
0 Resources
13 MeSH Terms
