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Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.
Seol Y, Gentry AC, Osheroff N, Neuman KC
(2013) J Biol Chem 288: 13695-703
MeSH Terms: Antigens, Neoplasm, DNA Replication, DNA Topoisomerases, Type II, DNA, Superhelical, DNA-Binding Proteins, Humans, Isomerism, Kinetics, Models, Molecular, Protein Structure, Tertiary, Sequence Deletion, Substrate Specificity
Added March 13, 2014
0 Communities
1 Members
0 Resources
12 MeSH Terms
Oxidative metabolites of curcumin poison human type II topoisomerases.
Ketron AC, Gordon ON, Schneider C, Osheroff N
(2013) Biochemistry 52: 221-7
MeSH Terms: Antineoplastic Agents, Coloring Agents, Curcuma, Curcumin, DNA Cleavage, DNA Topoisomerases, Type II, Humans, Oxidation-Reduction, Plant Extracts
Added March 7, 2014
0 Communities
2 Members
0 Resources
9 MeSH Terms
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity.
Schmidt BH, Osheroff N, Berger JM
(2012) Nat Struct Mol Biol 19: 1147-54
MeSH Terms: Adenylyl Imidodiphosphate, Amino Acid Sequence, Antigens, Neoplasm, Chromatography, Gel, Crystallization, DNA, DNA Topoisomerases, Type II, DNA-Binding Proteins, Dimerization, Models, Molecular, Molecular Sequence Data, Multiprotein Complexes, Protein Conformation, Saccharomyces cerevisiae
Added March 13, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA.
Lee S, Jung SR, Heo K, Byl JA, Deweese JE, Osheroff N, Hohng S
(2012) Proc Natl Acad Sci U S A 109: 2925-30
MeSH Terms: Amino Acids, Acidic, Antigens, Neoplasm, Base Sequence, Cations, Divalent, DNA, DNA Breaks, Double-Stranded, DNA Cleavage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Humans, Magnesium, Molecular Sequence Data, Nucleic Acid Conformation
Added March 13, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions.
Ketron AC, Denny WA, Graves DE, Osheroff N
(2012) Biochemistry 51: 1730-9
MeSH Terms: Amsacrine, Antigens, Neoplasm, Antineoplastic Agents, Binding Sites, DNA, DNA Cleavage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Humans, Intercalating Agents, Kinetics, Molecular Dynamics Simulation, Structure-Activity Relationship, Topoisomerase II Inhibitors
Added March 7, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Etoposide quinone is a redox-dependent topoisomerase II poison.
Jacob DA, Mercer SL, Osheroff N, Deweese JE
(2011) Biochemistry 50: 5660-7
MeSH Terms: Antigens, Neoplasm, Benzoquinones, Catechols, DNA Adducts, DNA Damage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Dithiothreitol, Enzyme Stability, Etoposide, Humans, Leukemia, Myeloid, Acute, Oxidation-Reduction, Reducing Agents
Added March 13, 2014
0 Communities
1 Members
0 Resources
14 MeSH Terms
Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.
Pitts SL, Jablonksy MJ, Duca M, Dauzonne D, Monneret C, Arimondo PB, Anklin C, Graves DE, Osheroff N
(2011) Biochemistry 50: 5058-66
MeSH Terms: Antigens, Neoplasm, Antineoplastic Agents, Phytogenic, Cell Line, Tumor, DNA, DNA Cleavage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Drug Interactions, Etoposide, Humans, Saccharomyces cerevisiae
Added March 7, 2014
0 Communities
1 Members
0 Resources
11 MeSH Terms
Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification.
Hardin AH, Sarkar SK, Seol Y, Liou GF, Osheroff N, Neuman KC
(2011) Nucleic Acids Res 39: 5729-43
MeSH Terms: Antigens, Neoplasm, DNA, DNA Topoisomerases, Type II, DNA-Binding Proteins, Fluorescence Resonance Energy Transfer, Humans, Microscopy, Atomic Force, Nucleic Acid Conformation
Added March 13, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.
Gentry AC, Pitts SL, Jablonsky MJ, Bailly C, Graves DE, Osheroff N
(2011) Biochemistry 50: 3240-9
MeSH Terms: Antigens, Neoplasm, Antineoplastic Agents, DNA, DNA Cleavage, DNA Topoisomerases, Type II, DNA-Binding Proteins, Drug Stability, Etoposide, Humans, Podophyllotoxin, Protein Binding, Spermine, Structure-Activity Relationship
Added March 7, 2014
0 Communities
1 Members
0 Resources
13 MeSH Terms
Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.
Wang Y, Coffey RJ, Osheroff N, Neufeld KL
(2010) PLoS One 5: e9994
MeSH Terms: Adenomatous Polyposis Coli, Adenomatous Polyposis Coli Protein, Aneuploidy, Antigens, Neoplasm, Binding Sites, Cell Cycle, Cell Line, Tumor, Codon, Nonsense, DNA Topoisomerases, Type II, DNA-Binding Proteins, Epithelial Cells, G2 Phase, Humans, Repetitive Sequences, Nucleic Acid, beta Catenin
Added August 12, 2010
1 Communities
1 Members
0 Resources
15 MeSH Terms