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Results: 11 to 20 of 530

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Kinetic Deuterium Isotope Effects in Cytochrome P450 Reactions.
Guengerich FP
(2017) Methods Enzymol 596: 217-238
MeSH Terms: Biocatalysis, Cytochrome P-450 Enzyme System, Deuterium, Enzyme Assays, Humans, Hydrogen Bonding, Kinetics, Models, Chemical, Oxidation-Reduction, Substrate Specificity
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage.
Velez Edwards DR, Edwards TL, Bray MJ, Torstenson E, Jones S, Shrubsole MJ, Muff HJ, Hartmann KE
(2017) Sci Rep 7: 9874
MeSH Terms: Abortion, Spontaneous, Adult, Alleles, Anti-Inflammatory Agents, Non-Steroidal, Cytochrome P-450 Enzyme System, Disease Susceptibility, Female, Genotype, Humans, Intramolecular Oxidoreductases, Odds Ratio, Polymorphism, Single Nucleotide, Pregnancy, Risk Factors
Added February 21, 2019
0 Communities
1 Members
0 Resources
14 MeSH Terms
Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.
Gangadhariah MH, Dieckmann BW, Lantier L, Kang L, Wasserman DH, Chiusa M, Caskey CF, Dickerson J, Luo P, Gamboa JL, Capdevila JH, Imig JD, Yu C, Pozzi A, Luther JM
(2017) Diabetologia 60: 1066-1075
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 2, Eicosanoids, Insulin Resistance, Islets of Langerhans, Male, Mesenteric Arteries, Mice
Added April 26, 2017
0 Communities
3 Members
0 Resources
9 MeSH Terms
Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.
Guedes-da-Silva FH, Batista DG, Da Silva CF, De Araújo JS, Pavão BP, Simões-Silva MR, Batista MM, Demarque KC, Moreira OC, Britto C, Lepesheva GI, Soeiro MN
(2017) Antimicrob Agents Chemother 61:
MeSH Terms: 14-alpha Demethylase Inhibitors, Animals, Chagas Disease, Cyclophosphamide, Cytochrome P-450 Enzyme System, Disease Models, Animal, Drug Administration Schedule, Female, Gene Expression, Humans, Imidazoles, Immunosuppressive Agents, Male, Mice, Models, Molecular, Nitroimidazoles, Oxadiazoles, Parasite Load, Recurrence, Survival Analysis, Trypanocidal Agents, Trypanosoma cruzi
Added July 2, 2021
0 Communities
1 Members
0 Resources
MeSH Terms
Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.
Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H
(2017) Xenobiotica 47: 844-848
MeSH Terms: Angiogenesis Inhibitors, Animals, Cytochrome P-450 Enzyme System, Glucuronides, Hepatocytes, Humans, Liver, Metabolome, Mice, Microsomes, Liver, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
11 MeSH Terms
Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl.
Shimada T, Kakimoto K, Takenaka S, Koga N, Uehara S, Murayama N, Yamazaki H, Kim D, Guengerich FP, Komori M
(2016) Drug Metab Dispos 44: 1899-1909
MeSH Terms: Animals, Catalysis, Catalytic Domain, Cytochrome P-450 CYP2A6, Cytochrome P-450 Enzyme System, Haplorhini, Humans, Ligands, Molecular Docking Simulation, Oxidation-Reduction, Polychlorinated Biphenyls, Protein Binding
Added March 14, 2018
0 Communities
1 Members
0 Resources
12 MeSH Terms
Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions.
Guengerich FP
(2017) Chem Res Toxicol 30: 2-12
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Drug Interactions, Humans, Pharmaceutical Preparations, Xenobiotics
Added March 14, 2018
0 Communities
1 Members
0 Resources
6 MeSH Terms
Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.
Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP
(2016) Chem Res Toxicol 29: 1279-81
MeSH Terms: Animals, Cytochrome P-450 Enzyme System, Electrophoresis, Gel, Two-Dimensional, Hepatocytes, Humans, Mass Spectrometry, Mice, Protein Binding, Thalidomide
Added March 14, 2018
0 Communities
1 Members
0 Resources
9 MeSH Terms
Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.
Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP
(2016) Chem Res Toxicol 29: 1903-1911
MeSH Terms: Activation, Metabolic, Animals, Chimera, Cytochrome P-450 Enzyme System, Humans, Liver, Mass Spectrometry, Mice, Thalidomide, Toxicokinetics
Added March 14, 2018
0 Communities
1 Members
0 Resources
10 MeSH Terms
Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.
Ačimovič J, Goyal S, Košir R, Goličnik M, Perše M, Belič A, Urlep Ž, Guengerich FP, Rozman D
(2016) Sci Rep 6: 28462
MeSH Terms: Animals, Cholesterol, Cyclic AMP Response Element Modulator, Cytochrome P-450 Enzyme System, Gas Chromatography-Mass Spectrometry, Humans, Lanosterol, Male, Mice, Mice, Knockout, Models, Theoretical, Oxidation-Reduction, Rats, Recombinant Proteins, Sterols, Testis
Added March 14, 2018
0 Communities
1 Members
0 Resources
16 MeSH Terms