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Results: 11 to 20 of 61

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Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds.
Shimada T, Murayama N, Tanaka K, Takenaka S, Guengerich FP, Yamazaki H, Komori M
(2011) Chem Res Toxicol 24: 1327-37
MeSH Terms: Animals, Antineoplastic Agents, Aryl Hydrocarbon Hydroxylases, Binding Sites, Biocatalysis, Catalytic Domain, Computer Simulation, Cyanates, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2A6, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Neoplasms, Organoselenium Compounds, Protein Binding, Rats
Added March 26, 2014
0 Communities
1 Members
0 Resources
20 MeSH Terms
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.
Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2010) Chem Res Toxicol 23: 1921-35
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Binding Sites, Computer Simulation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Flavonoids, Humans, Kinetics, Structure-Activity Relationship
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms
Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.
Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR
(2010) J Biol Chem 285: 25582-90
MeSH Terms: Animals, Antifungal Agents, Chagas Disease, Crystallography, X-Ray, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Humans, Immunoblotting, Molecular Structure, Myocytes, Cardiac, Protein Structure, Secondary, Triazoles, Trypanosoma cruzi
Added February 12, 2015
0 Communities
2 Members
0 Resources
13 MeSH Terms
Cataloging the Repertoire of Nature's Blowtorch, P450.
Guengerich FP
(2009) Chem Biol 16: 1215-6
MeSH Terms: Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Databases, Factual, Enzyme Inhibitors, Humans, Ligands, Structure-Activity Relationship, Substrate Specificity
Added May 26, 2014
0 Communities
1 Members
0 Resources
8 MeSH Terms
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR
(2010) J Biol Chem 285: 1773-80
MeSH Terms: Amino Acid Sequence, Benzamides, Biocatalysis, Crystallography, X-Ray, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Design, Enzyme Inhibitors, Humans, Ligands, Microsomes, Models, Molecular, Protein Conformation, Sterol 14-Demethylase, Sterols, Substrate Specificity, Trypanocidal Agents, Trypanosoma brucei brucei, Trypanosomiasis, African
Added March 7, 2014
0 Communities
3 Members
0 Resources
19 MeSH Terms
Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.
Shimada T, Tanaka K, Takenaka S, Foroozesh MK, Murayama N, Yamazaki H, Guengerich FP, Komori M
(2009) Chem Res Toxicol 22: 1325-33
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Biphenyl Compounds, Cytochrome P-450 CYP1B1, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Flavonoids, Humans, Hydrocarbons, Aromatic, Kinetics, Naphthalenes, Phenanthrenes, Protein Binding, Pyrenes, Spectrophotometry, Ultraviolet, Stilbenes, Structure-Activity Relationship
Added March 26, 2014
0 Communities
1 Members
0 Resources
17 MeSH Terms
The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis.
Yang S, Wei S, Pozzi A, Capdevila JH
(2009) Arch Biochem Biophys 489: 82-91
MeSH Terms: Animals, Antifungal Agents, Cell Proliferation, Cells, Cultured, Cytochrome P-450 CYP2J2, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 2, Endothelial Cells, Enzyme Activation, Ketoconazole, Lung, MAP Kinase Signaling System, Mice, Mice, Transgenic, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Neovascularization, Physiologic, Phosphorylation, Proto-Oncogene Proteins c-akt, RNA, Small Interfering, Vascular Endothelial Growth Factor A
Added February 24, 2014
0 Communities
2 Members
0 Resources
22 MeSH Terms
Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.
Konkle ME, Hargrove TY, Kleshchenko YY, von Kries JP, Ridenour W, Uddin MJ, Caprioli RM, Marnett LJ, Nes WD, Villalta F, Waterman MR, Lepesheva GI
(2009) J Med Chem 52: 2846-53
MeSH Terms: Amides, Animals, Antiparasitic Agents, Cytochrome P-450 Enzyme Inhibitors, Drug Evaluation, Preclinical, Enzyme Inhibitors, Extracellular Space, Indomethacin, Intracellular Space, Ligands, Sterol 14-Demethylase, Sterols, Trypanosoma cruzi
Added March 5, 2014
0 Communities
4 Members
0 Resources
13 MeSH Terms
CYP51: A major drug target in the cytochrome P450 superfamily.
Lepesheva GI, Hargrove TY, Kleshchenko Y, Nes WD, Villalta F, Waterman MR
(2008) Lipids 43: 1117-25
MeSH Terms: Animals, Azoles, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Drug Design, Humans, Microbial Sensitivity Tests, Molecular Structure, Protozoan Proteins, Sterols, Substrate Specificity, Trypanosoma
Added February 12, 2015
0 Communities
2 Members
0 Resources
12 MeSH Terms
Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.
Lepesheva GI, Ott RD, Hargrove TY, Kleshchenko YY, Schuster I, Nes WD, Hill GC, Villalta F, Waterman MR
(2007) Chem Biol 14: 1283-93
MeSH Terms: Animals, Antiprotozoal Agents, Cytochrome P-450 Enzyme Inhibitors, Oxidoreductases, Sterol 14-Demethylase, Substrate Specificity, Trypanosoma brucei brucei, Trypanosoma cruzi, Trypanosomiasis
Added February 12, 2015
0 Communities
2 Members
0 Resources
9 MeSH Terms