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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 33

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Applied pharmacogenomics in cardiovascular medicine.
Weeke P, Roden DM
(2014) Annu Rev Med 65: 81-94
MeSH Terms: Adrenergic beta-Antagonists, Antihypertensive Agents, Antithrombins, Aryl Hydrocarbon Hydroxylases, Cardiovascular Diseases, Clopidogrel, Cytochrome P-450 CYP2C19, Cytochrome P-450 CYP2C9, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Liver-Specific Organic Anion Transporter 1, Organic Anion Transporters, Pharmacogenetics, Polymorphism, Single Nucleotide, Precision Medicine, Ticlopidine, Vitamin K Epoxide Reductases, Warfarin
Added March 7, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Ethnicity-specific pharmacogenetics: the case of warfarin in African Americans.
Hernandez W, Gamazon ER, Aquino-Michaels K, Patel S, O'Brien TJ, Harralson AF, Kittles RA, Barbour A, Tuck M, McIntosh SD, Douglas JN, Nicolae D, Cavallari LH, Perera MA
(2014) Pharmacogenomics J 14: 223-8
MeSH Terms: Anticoagulants, Cohort Studies, Cytochrome P-450 CYP2C9, Female, Humans, Male, Pharmacogenetics, Vitamin K Epoxide Reductases, Warfarin
Added April 13, 2017
0 Communities
1 Members
0 Resources
9 MeSH Terms
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.
Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA
(2013) Lancet 382: 790-6
MeSH Terms: African Americans, Alleles, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Female, Genome-Wide Association Study, Genotype, Humans, Male, Mixed Function Oxygenases, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin
Added March 7, 2014
0 Communities
3 Members
0 Resources
14 MeSH Terms
Warfarin pharmacogenomics in children.
Vear SI, Stein CM, Ho RH
(2013) Pediatr Blood Cancer 60: 1402-7
MeSH Terms: Adolescent, Adult, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Child, Child, Preschool, Cytochrome P-450 CYP2C9, Female, Humans, International Normalized Ratio, Male, Mixed Function Oxygenases, Pharmacogenetics, Vitamin K Epoxide Reductases, Warfarin
Added March 5, 2014
1 Communities
1 Members
0 Resources
16 MeSH Terms
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record.
Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC
(2012) Pharmacogenomics 13: 407-18
MeSH Terms: Adult, African Americans, Aged, Aged, 80 and over, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Calcium-Binding Proteins, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Drug Administration Schedule, Electronic Health Records, Female, Humans, Male, Middle Aged, Mixed Function Oxygenases, Polymorphism, Single Nucleotide, Substance-Related Disorders, Vitamin K Epoxide Reductases, Warfarin, Whites
Added December 10, 2013
0 Communities
5 Members
0 Resources
23 MeSH Terms
Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.
Gong IY, Schwarz UI, Crown N, Dresser GK, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Wells PS, Kim RB, Tirona RG
(2011) PLoS One 6: e27808
MeSH Terms: Adult, Aged, Aged, 80 and over, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Blood Coagulation, Cytochrome P-450 CYP2C9, Cytochrome P-450 Enzyme System, Cytochrome P450 Family 4, Dose-Response Relationship, Drug, Female, Gene Frequency, Genotype, Humans, Kidney Function Tests, Male, Middle Aged, Mixed Function Oxygenases, Prospective Studies, Tissue Distribution, Vitamin K, Vitamin K Epoxide Reductases, Warfarin, Young Adult
Added June 26, 2014
0 Communities
1 Members
0 Resources
25 MeSH Terms
Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy.
Gong IY, Tirona RG, Schwarz UI, Crown N, Dresser GK, Larue S, Langlois N, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Carrier M, Forgie M, Wells PS, Kim RB
(2011) Blood 118: 3163-71
MeSH Terms: Adult, Aged, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cohort Studies, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Drug Resistance, Female, Humans, Male, Middle Aged, Mixed Function Oxygenases, Pharmacogenetics, Polymorphism, Single Nucleotide, Vitamin K Epoxide Reductases, Warfarin, Whole Blood Coagulation Time
Added June 26, 2014
0 Communities
1 Members
0 Resources
18 MeSH Terms
Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin.
Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC
(2011) J Am Med Inform Assoc 18: 387-91
MeSH Terms: Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2C9, Data Mining, Databases, Nucleic Acid, Drug Dosage Calculations, Electronic Health Records, Genome-Wide Association Study, Humans, Linear Models, Mixed Function Oxygenases, Natural Language Processing, Pharmacogenetics, Precision Medicine, United States, Vitamin K Epoxide Reductases, Warfarin
Added December 10, 2013
0 Communities
3 Members
0 Resources
18 MeSH Terms
The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.
Perera MA, Gamazon E, Cavallari LH, Patel SR, Poindexter S, Kittles RA, Nicolae D, Cox NJ
(2011) Clin Pharmacol Ther 89: 408-15
MeSH Terms: African Americans, Algorithms, Anticoagulants, Aryl Hydrocarbon Hydroxylases, Base Sequence, Cohort Studies, Cytochrome P-450 CYP2C9, Dose-Response Relationship, Drug, Female, Genetic Variation, Humans, Male, Middle Aged, Mixed Function Oxygenases, Polymorphism, Single Nucleotide, Regression Analysis, Vitamin K Epoxide Reductases, Warfarin
Added February 22, 2016
0 Communities
2 Members
0 Resources
18 MeSH Terms
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.
Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M
(2010) Chem Res Toxicol 23: 1921-35
MeSH Terms: Aryl Hydrocarbon Hydroxylases, Binding Sites, Computer Simulation, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP1B1, Cytochrome P-450 CYP2C9, Cytochrome P-450 CYP3A, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Cytochrome P-450 Enzyme System, Flavonoids, Humans, Kinetics, Structure-Activity Relationship
Added March 7, 2014
0 Communities
1 Members
0 Resources
16 MeSH Terms