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The publication data currently available has been vetted by Vanderbilt faculty, staff, administrators and trainees. The data itself is retrieved directly from NCBI's PubMed and is automatically updated on a weekly basis to ensure accuracy and completeness.

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Results: 11 to 20 of 21

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Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
Holzinger ER, Grady B, Ritchie MD, Ribaudo HJ, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford DB, Daar ES, McLaren P, Haas DW
(2012) Pharmacogenet Genomics 22: 858-67
MeSH Terms: Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Clinical Protocols, Cyclopropanes, Cytochrome P-450 CYP2B6, Genetic Association Studies, Genetic Variation, Genome, Human, Genome-Wide Association Study, HIV Infections, Humans, Oxidoreductases, N-Demethylating, Polymorphism, Genetic
Added March 13, 2015
0 Communities
1 Members
0 Resources
15 MeSH Terms
Neuropsychometric correlates of efavirenz pharmacokinetics and pharmacogenetics following a single oral dose.
Johnson DH, Gebretsadik T, Shintani A, Mayo G, Acosta EP, Stein CM, Haas DW
(2013) Br J Clin Pharmacol 75: 997-1006
MeSH Terms: Administration, Oral, Adult, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, Humans, Male, Oxidoreductases, N-Demethylating, Psychomotor Performance
Added March 13, 2015
0 Communities
1 Members
0 Resources
14 MeSH Terms
Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium.
Wassel CL, Lamina C, Nambi V, Coassin S, Mukamal KJ, Ganesh SK, Jacobs DR, Franceschini N, Papanicolaou GJ, Gibson Q, Yanek LR, van der Harst P, Ferguson JF, Crawford DC, Waite LL, Allison MA, Criqui MH, McDermott MM, Mehra R, Cupples LA, Hwang SJ, Redline S, Kaplan RC, Heiss G, Rotter JI, Boerwinkle E, Taylor HA, Eraso LH, Haun M, Li M, Meisinger C, O'Connell JR, Shuldiner AR, Tybjærg-Hansen A, Frikke-Schmidt R, Kollerits B, Rantner B, Dieplinger B, Stadler M, Mueller T, Haltmayer M, Klein-Weigel P, Summerer M, Wichmann HE, Asselbergs FW, Navis G, Mateo Leach I, Brown-Gentry K, Goodloe R, Assimes TL, Becker DM, Cooke JP, Absher DM, Olin JW, Mitchell BD, Reilly MP, Mohler ER, North KE, Reiner AP, Kronenberg F, Murabito JM
(2012) Atherosclerosis 222: 138-47
MeSH Terms: Adult, African Americans, Aged, Ankle Brachial Index, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2B6, Female, Humans, Male, Middle Aged, Oxidoreductases, N-Demethylating, Peripheral Arterial Disease, Polymorphism, Single Nucleotide, Risk Factors, Transcription Factor 7-Like 2 Protein, Whites
Added December 10, 2013
0 Communities
2 Members
0 Resources
16 MeSH Terms
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study.
Ribaudo HJ, Liu H, Schwab M, Schaeffeler E, Eichelbaum M, Motsinger-Reif AA, Ritchie MD, Zanger UM, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford D, Haas DW
(2010) J Infect Dis 202: 717-22
MeSH Terms: ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Blacks, Cyclopropanes, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Female, HIV Infections, Hispanic or Latino, Humans, Male, Oxidoreductases, N-Demethylating, Pharmacogenetics, Polymorphism, Single Nucleotide, Reverse Transcriptase Inhibitors, Treatment Outcome, Whites
Added March 13, 2015
0 Communities
1 Members
0 Resources
21 MeSH Terms
CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.
Leger P, Dillingham R, Beauharnais CA, Kashuba AD, Rezk NL, Fitzgerald DW, Pape JW, Haas DW
(2009) J Infect Dis 200: 955-64
MeSH Terms: Adult, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Base Sequence, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, HIV Infections, Haiti, Haplotypes, Humans, Linkage Disequilibrium, Male, Oxidoreductases, N-Demethylating, Polymorphism, Genetic
Added March 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.
Haas DW, Gebretsadik T, Mayo G, Menon UN, Acosta EP, Shintani A, Floyd M, Stein CM, Wilkinson GR
(2009) J Infect Dis 199: 872-80
MeSH Terms: Alkynes, Anti-HIV Agents, Area Under Curve, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Blacks, Cyclopropanes, Cytochrome P-450 CYP2B6, Genotype, HIV Seronegativity, Humans, Linkage Disequilibrium, Metabolic Clearance Rate, Nevirapine, Oxidoreductases, N-Demethylating, Polymorphism, Genetic, Safety
Added March 13, 2015
0 Communities
1 Members
0 Resources
17 MeSH Terms
Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration.
Haas DW, Bartlett JA, Andersen JW, Sanne I, Wilkinson GR, Hinkle J, Rousseau F, Ingram CD, Shaw A, Lederman MM, Kim RB, Adult AIDS Clinical Trials Group
(2006) Clin Infect Dis 43: 783-6
MeSH Terms: Adult, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Case-Control Studies, Chemical and Drug Induced Liver Injury, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Female, Gene Frequency, Genes, MDR, Genotype, HIV Infections, HIV-1, Humans, Liver, Liver Diseases, Male, Nevirapine, Oxidoreductases, N-Demethylating, Polymorphism, Genetic, Randomized Controlled Trials as Topic, Reverse Transcriptase Inhibitors, South Africa
Added March 13, 2015
0 Communities
1 Members
0 Resources
24 MeSH Terms
Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity.
Ritchie MD, Haas DW, Motsinger AA, Donahue JP, Erdem H, Raffanti S, Rebeiro P, George AL, Kim RB, Haines JL, Sterling TR
(2006) Clin Infect Dis 43: 779-82
MeSH Terms: Adult, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Case-Control Studies, Chemical and Drug Induced Liver Injury, Cyclopropanes, Cytochrome P-450 CYP2B6, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Female, Genes, MDR, Genetic Variation, Genotype, HIV Infections, HIV-1, Humans, Liver, Liver Diseases, Male, Nevirapine, Oxazines, Oxidoreductases, N-Demethylating, Reverse Transcriptase Inhibitors
Added March 13, 2015
0 Communities
1 Members
0 Resources
25 MeSH Terms
Efavirenz and CYP2B6 polymorphism: implications for drug toxicity and resistance.
Nolan D, Phillips E, Mallal S
(2006) Clin Infect Dis 42: 408-10
MeSH Terms: Alkynes, Aryl Hydrocarbon Hydroxylases, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Drug Resistance, Viral, Genotype, HIV Infections, Humans, Oxazines, Oxidoreductases, N-Demethylating, Phenotype, Polymorphism, Genetic
Added March 30, 2020
0 Communities
1 Members
0 Resources
13 MeSH Terms
Pharmacogenetics of plasma efavirenz exposure after treatment discontinuation: an Adult AIDS Clinical Trials Group Study.
Ribaudo HJ, Haas DW, Tierney C, Kim RB, Wilkinson GR, Gulick RM, Clifford DB, Marzolini C, Fletcher CV, Tashima KT, Kuritzkes DR, Acosta EP, Adult AIDS Clinical Trials Group Study
(2006) Clin Infect Dis 42: 401-7
MeSH Terms: Acquired Immunodeficiency Syndrome, Adult, African Americans, Alkynes, Anti-HIV Agents, Aryl Hydrocarbon Hydroxylases, Asians, Benzoxazines, Cyclopropanes, Cytochrome P-450 CYP2B6, Female, Genotype, Half-Life, Hispanic or Latino, Humans, Male, Native Hawaiian or Other Pacific Islander, Oxazines, Oxidoreductases, N-Demethylating, Polymorphism, Genetic, Viral Load, Whites
Added March 13, 2015
0 Communities
1 Members
0 Resources
22 MeSH Terms